DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Sh3bp1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001303613.1	Gene:	Sh3bp1 / 20401	MGIID:	104603	Length:	680	Species:	Mus musculus

Alignment Length:	567	Identity:	128/567 - (22%)
Similarity:	212/567 - (37%)	Gaps:	139/567 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEFLNEYYLQSNSQSIEP--EASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLS 78
            :|||.|..||. .|.:||  .|::...:.....|..          :.|.::.|:..:..|..||
Mouse    25 AEFLGEDLLQV-EQRLEPAKRAAHNVHKRLQACLQG----------QSGADMDKRVKKLPLMALS 78

  Fly    79 KPHAEAIVQL------VRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSL 137
            ...||:..:|      .:.|..|..::.:        :..:..||:    :|..|       |.|
Mouse    79 TTMAESFKELDPDSSMGKALEMTCAIQNQ--------LARILAEFE----MTLER-------DVL 124

  Fly   138 QIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADI--FRGSQV 200
            |.....:...||..:    |:.::..:.|...|.  ||..|.:   |...||:...:  ..||..
Mouse   125 QPLSRLSEEELPAIL----KHKKSLQKLVSDWNT--LKSRLSQ---AAKNSGSNQGLGGASGSHT 180

  Fly   201 RCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASE 265
            ...    :|:.||:|                          ||...|     .|||..:
Mouse   181 HTT----TANKVEML--------------------------KEEEEE-----LKKKVEQ------ 204

  Fly   266 NECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELA 330
                               |:|....|........|..:..|..::.|.....::..|.|...||
Mouse   205 -------------------CKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALA 250

  Fly   331 TIFDRNKVS----LDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELL 391
            .:.|.:..:    |....||.|       ::|||    :|...|..|.|   :.|.:|..:..||
Mouse   251 ELRDNHSQADHSPLTTAAPFSR-------VYGVS----LRTHLQDLGRD---IALPIEACVLLLL 301

  Fly   392 RRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLL 456
            ..|.:||||.|:.....    :...|:.|...:|.:|:..  .:..|.::..||.:|||||:||:
Mouse   302 SEGMQEEGLFRLAAGAS----VLKRLKQTMASDPHSLEEF--CSDPHAVAGALKSYLRELPEPLM 360

  Fly   457 TNELIQLFYQCHTL--PSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVA 519
            |::|...:.:..:|  |.. ::.||..:|..||.||.|.||.|:.|..::...:|:|||...|:|
Mouse   361 TSDLYDDWMRAASLKEPGA-RLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIA 424

  Fly   520 TIMAPS-MFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF 565
            .::.|: ::||.  ...|...:......:.|...:...||...:.||
Mouse   425 IVLGPNLLWPPE--KEGDQAQLDAASVSSIQVVGVVEALIQNADTLF 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	62/213 (29%)
Sh3bp1	NP_001303613.1	Interaction with CGNL1. /evidence=ECO:0000250\|UniProtKB:Q9Y3L3	1..275		66/355 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		BAR_SH3BP1	16..275	CDD:153304	66/355 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..184		5/30 (17%)
		RhoGAP	272..473	CDD:295372	63/221 (29%)
		Interaction with CD2AP. /evidence=ECO:0000250\|UniProtKB:Q9Y3L3	470..680		128/567 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..680
		SH3-binding. /evidence=ECO:0000269\|PubMed:8438166	607..616
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910