DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conu and Ralbp1

DIOPT Version :9

Sequence 1:NP_001036454.1 Gene:conu / 3355133 FlyBaseID:FBgn0039994 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001185878.1 Gene:Ralbp1 / 19765 MGIID:108466 Length:648 Species:Mus musculus


Alignment Length:499 Identity:98/499 - (19%)
Similarity:171/499 - (34%) Gaps:154/499 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 IGTIQFP---RNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSF 281
            |...:||   |....|.|...:....::.|::|....|||            |:..........:
Mouse    33 ISPTKFPGLYRTGEPSPPHDVLHEPPDTVSDDDKDHGKKK------------GKFKKKEKRTEGY 85

  Fly   282 ESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPF 346
            .:...|||.       |..:.||            .:||.:.|      .:|.:...|..|.|.|
Mouse    86 AAFQEDSSG-------DEAESPS------------KVKRSKGI------HVFKKPSFSKKKEKDF 125

  Fly   347 K------------RRRKEEGN------------------------------------------LF 357
            |            .:.|||.:                                          :|
Mouse   126 KIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQMDAPSVKPIF 190

  Fly   358 GVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF- 421
            ||.:...:.|.....|.   .:|....:.:..:.:.|.:.||:.|:.|.|.|.:    ||::.: 
Mouse   191 GVPLVDAVERTMMYDGV---RLPAVFRECVDYMEKHGMKCEGVYRVSGIKSKVD----ELKAAYD 248

  Fly   422 YQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ-CHTLPSIDQMNALSILCHL 485
            .:...||:. :...||   :||||::||:||:.|||.||:..|.: |.....::::.....|...
Mouse   249 REESPNLEE-YEPNTV---ASLLKQYLRDLPENLLTKELMPRFEEACGKTTEMEKVQEFQRLLRE 309

  Fly   486 LPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPS-----------------MF------ 527
            ||..|...|..|:...:.:|..:...|||:.|::.:::|:                 :|      
Mouse   310 LPECNHLLLSWLIVHLDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLK 374

  Fly   528 ----PPRYIH-------PSDNNSIAEQVRMAAQCCRLTNIL----------ILRGEKLFQVPNNL 571
                |.|:.:       |.....|.|::|...   .|.|.|          :.:.|:|::|...|
Mouse   375 QVTRPLRWSNMATMPTLPETQAGIKEEIRRQE---FLLNCLHRDLQGGIKDLSKEERLWEVQRIL 436

  Fly   572 IVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVGVGHDSTVIN 615
            ....:|....|:.....:.:.||.:......|...:..:..|||
Mouse   437 TALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVIN 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
conuNP_001036454.1 RhoGAP_ARHGAP18 356..576 CDD:239856 60/265 (23%)
Ralbp1NP_001185878.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..158 30/161 (19%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9PT60 102..119 4/22 (18%)
Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000250|UniProtKB:Q15311 154..219 6/67 (9%)
RhoGap_RalBP1 190..371 CDD:239846 47/191 (25%)
Mediates interaction with RALA and RALB. /evidence=ECO:0000250|UniProtKB:Q15311 403..499 16/81 (20%)
Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000250|UniProtKB:Q62796 500..648
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..552
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..648
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.