DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Myo9a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_599162.2	Gene:	Myo9a / 171296	RGDID:	621395	Length:	2626	Species:	Rattus norvegicus

Alignment Length:	723	Identity:	141/723 - (19%)
Similarity:	243/723 - (33%)	Gaps:	229/723 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPI--LTTLSKPHAEAIVQLVRTLNKTVRV 98
            ::.|||.:.|   ...|.::.:|.....:.|..:|.|:  |...|...:|...|...::::..|:
  Rat  1736 TFADGEGDTE---EDDYDDIIEPLLSLDQASHSELGPVSSLGQASHSDSEMTSQRFSSVDEQARL 1797

  Fly    99 R--------TKSRPKRKPDIRDV--------FREFDEQG--TVTRSRSATPDSLDSLQIDEAWT- 144
            .        ||...::|....|:        |....:||  ..||.:.|....:.||......|
  Rat  1798 HKAMSQGEITKLAGRQKSSDLDIRPQRAKMRFWAKGKQGEKKTTRVKPAPQSEVSSLFAGSDVTP 1862

  Fly   145 ----NNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIP 205
                ::.|..:......:.|....|.::     .|:|...:|.|..|.|.     :.|.|..|..
  Rat  1863 VHPFSDELTQYHPTPPLSPELPGSCRKE-----FKENKEPSPKAKRKRGV-----KISSVALDSM 1917

  Fly   206 LYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGR 270
            .:..|.|:::.                             |.||.:|..:...:.::..:||..:
  Rat  1918 HWQNDSVQIIA-----------------------------SANDLKSMDEFLLKKMNDLDNEDSK 1953

  Fly   271 ---LLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTI-------- 324
               |:.:.:.....|......||..|...:|  |..|..:.|:..:.|..:::....
  Rat  1954 KDTLVDVVFKKALKEFRQNIFSSYSSALAMD--DGKSIRYKDLYALFEQILEKTMRFEQRDWNES 2016

  Fly   325 ---LWLELATIF-DR--NKV-SLDKRKP------FKRRRKEEGNL-------------------- 356
               :|:....:| |.  |:. :||...|      .|:|||:|.:|
  Rat  2017 PVRVWVNTFKVFLDEYMNEFKTLDSTAPKVLKTERKKRRKKETDLVEEHNGHMFKATQYSIPTYC 2081

  Fly   357 -----------------------------------------------FGVSINALIRRDQQVTGT 374
                                                           |||.::.|...|:
  Rat  2082 EYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDR----- 2141

  Fly   375 DSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHE 439
               .|||.:||||..:...|...||:.|..|...|.:.|...|::.  ....|||:.    .:|.
  Rat  2142 ---AVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD--AESVNLDDY----NIHV 2197

  Fly   440 LSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS-----------IDQMNALSILCHLLPPENRNT 493
            ::|:.|:|||:||.||:|.||.:.|.:...|..           |||::.    .||      :|
  Rat  2198 IASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSR----THL------ST 2252

  Fly   494 LRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQC-------- 550
            |..|:.....|...:|.|:|:.:.:|.:.||.:.  |....:|.....:.:.....|
  Rat  2253 LERLIFHLVRIALQEDTNRMSANALAIVFAPCIL--RCPDTTDPLQSVQDISKTTTCVELIVVEQ 2315

  Fly   551 -----CRLTNI---------------LILRGEKLFQVPNNLIVESQKTMMGK----KGWHRHRNS 591
                 .||.:|               ||.|..|...:....:..::.::.||    :|.|.:.:|
  Rat  2316 MNKYKARLKDISSLEFAENKAKTRLSLIRRSMKPVLIAVRFMSITRSSVSGKGRLHRGSHPNPSS 2380

  Fly   592 NEITAKPS 599
            ..|...||
  Rat  2381 PVIVRLPS 2388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	64/325 (20%)
Myo9a	NP_599162.2	Actin-binding. /evidence=ECO:0000250	908..919
		Neck or regulatory domain. /evidence=ECO:0000250	1022..1163
		Tail. /evidence=ECO:0000250	1164..2589		141/723 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1397
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1562..1602
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1618..1673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1689..1726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1765..1784		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1872..1907		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2365..2385		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2449..2527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2552..2614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910