DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Arhgap4

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_011245832.1	Gene:	Arhgap4 / 171207	MGIID:	2159577	Length:	965	Species:	Mus musculus

Alignment Length:	580	Identity:	122/580 - (21%)
Similarity:	196/580 - (33%)	Gaps:	162/580 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 QGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTR 125
            |||    ..||..|..|..|..:|.|..|..:.....:|.:.:|....::.:|..|.:....:..
Mouse   315 QGL----GSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFEYQPHEDDEVAEVLIEMELWDEILP 375

  Fly   126 SRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGT 190
            ........||...|:....|.:|        |.|..|:.....|.:..:..:|:.:||......|
Mouse   376 RAQNIQSRLDQKTIETEEVNKTL--------KATLKALLEAVASEDGDILDSLQASPSTESLKST 432

  Fly   191 YADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVS-----------DPFCSIGRSKES 244
            .:|           |               ||.|..|.|:..           ..:.| |||..|
Mouse   433 SSD-----------P---------------GTRQTGRRRNQQQETETFYITKLQEYLS-GRSILS 470

  Fly   245 RSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTD 309
            :    .:::.:|..|.:.....|                  :..:|...|
Mouse   471 K----LQAKHEKLQEAIQQGNKE------------------KQETSRTQC--------------- 498

  Fly   310 VVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGT 374
                  |:.|                    ..|..|...|.:....|||..:...|:...|.
Mouse   499 ------TERK--------------------FHKSHPPHPRFQYNQRLFGGDLEKFIQSSGQP--- 534

  Fly   375 DSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHE 439
                |||.:|..|..:...|.:.||:.|:.|.:.:    .:|:...|.:..|.|:   :..|||:
Mouse   535 ----VPLVVESCIRFINLNGLQHEGIFRVSGAQAR----ISEIRDAFERGEDPLE---KGCTVHD 588

  Fly   440 LSS---LLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSF 500
            |.|   :||.:.|.|..||...::.........|..: :::..:|.|...||......||.|.:|
Mouse   589 LDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVEPVSHLLFKLPRPVLVVLRYLFTF 653

  Fly   501 FNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF 565
            .|.:....|.|.|:.:|:|....|::.|.    |:..:.:|.|.|:.    :|...|||:..::|
Mouse   654 LNHLAQYSDENMMDSYNLAVCFGPTLLPV----PAGQDPVALQGRVN----QLVQTLILQPARIF 710

  Fly   566 QVPNNL---IVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVGVGHDSTVINKYSTNLK 622
            ..|..|   |.|  |.|                |.||  ||.:|.|...::|.:....||
Mouse   711 PPPAMLPGPIYE--KCM----------------APPS--ASCLGDGQLESLIGEPELELK 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	60/226 (27%)
Arhgap4	XP_011245832.1	F-BAR_srGAP	30..296	CDD:153340
		RhoGAP	518..705	CDD:383032	54/208 (26%)
		SH3	769..823	CDD:388381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910