DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP42

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_689645.2	Gene:	ARHGAP42 / 143872	HGNCID:	26545	Length:	874	Species:	Homo sapiens

Alignment Length:	409	Identity:	94/409 - (22%)
Similarity:	159/409 - (38%)	Gaps:	94/409 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 FCSIGRSKE--SRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVL 297
            :|:..:..:  :.|.::.:|..|.:..|.|:.|                      ...|.||...
Human   288 YCTYDKGSKTFTMSVSEMKSSGKMNGLVTSSPE----------------------MFKLKSCIRR 330

  Fly   298 DTCDIPSTLFTDVVLISETDMKRLQTI------LWLELATIFDRNKVSLDKRKPFKRRRKEEGNL 356
            .|..|......|:.::....:..||..      ||||          ::|.::|.
Human   331 KTDSIDKRFCFDIEVVERHGIITLQAFSEANRKLWLE----------AMDGKEPI---------- 375

  Fly   357 FGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF 421
              .::.|:|.:.:::...::..  .|:.|.|..:..||....||.||||...|.:.|.|   :||
Human   376 --YTLPAIISKKEEMYLNEAGF--NFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMN---TTF 433

  Fly   422 Y-QNPDNLD---NLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCH-----TLPSIDQ-- 475
            . ::|.::|   .|:...|:   :|.||.:||.|.:||:|       |:.|     .:.|.||
Human   434 SPKSPPDIDIDIELWDNKTI---TSGLKNYLRCLAEPLMT-------YKLHKDFIIAVKSDDQNY 488

  Fly   476 -MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNS 539
             :.|:..|.|.||.:||..|..|:.....:......|.|.|.|:..|..|::.      .:...:
Human   489 RVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLM------RAQEET 547

  Fly   540 IAEQVRMAAQCCRLTNILILRGEKLFQ-VPNNLIVESQKTMMGKKGWHRHRNSNEITA--KPSGK 601
            :|..:.:..|.. :..|||...||:|. .|:..|...|.  ..:.|..|.|.....|.  ||.|:
Human   548 VAAMMNIKFQNI-VVEILIEHYEKIFHTAPDPSIPLPQP--QSRSGSRRTRAICLSTGSRKPRGR 609

  Fly   602 ASNVGVGHDSTVINKYSTN 620
            .:......||   :.||::
Human   610 YTPCLAEPDS---DSYSSS 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	61/232 (26%)
ARHGAP42	NP_689645.2	BAR_GAP10-like	19..225	CDD:153318
		BAR-PH_GRAF_family	267..376	CDD:269953	21/131 (16%)
		RhoGAP_Graf	369..567	CDD:239839	58/231 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..720		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..777
		SH3_GRAF3	820..874	CDD:212999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910