DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and AgaP_AGAP008833

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_319577.4	Gene:	AgaP_AGAP008833 / 1279799	VectorBaseID:	AGAP008833	Length:	603	Species:	Anopheles gambiae

Alignment Length:	626	Identity:	312/626 - (49%)
Similarity:	410/626 - (65%)	Gaps:	60/626 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSR 103
            |||:|||||.|||:|:|||.||:|.|:|..:|.|:::.||..||||:.|.|:.||:|||.||::|
Mosquito     3 DGELEAEWLNSAGFPQLTKAFEEGRELSATELAPVISGLSSMHAEAVKQRVKALNRTVRGRTRNR 67

  Fly   104 PKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWT----------NNSLPTFVNVYEKN 158
            ..:|||||||||:.|...|.||||||||||||||..|:||.          :..:|:||:|::.|
Mosquito    68 STKKPDIRDVFRDQDSSSTGTRSRSATPDSLDSLPGDDAWNTPPGNGHHHHHPHIPSFVSVFDGN 132

  Fly   159 TETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTI 223
            .      |.:...|..||:||||||||.:..  |::||||.:|||||::: :|:|||.:.|:|||
Mosquito   133 G------VVRPTPIRGKQHLRRTPSAPLRGS--AELFRGSHIRCDIPIHN-EGIELLNFQRLGTI 188

  Fly   224 QFPRNRSVSDPFCSIGR-----------------SKESRSENDARSQKKKSSEVLSASENECGRL 271
            ..||.||.|||.|:||.                 |..|.||....|...::|.:.|:.||.   .
Mosquito   189 HIPRIRSGSDPSCTIGHTNLYNGSAVAVRRDNDDSGNSSSEQSPPSSPPRNSLLCSSVENS---P 250

  Fly   272 LPMPYNVLSFESICRDS--SSLDSCE-----VLDTCDIPSTLFTDVVLISETDMKRLQTILWLEL 329
            |...|..:||||:.:.:  |:.|..|     ..:.|       .|:..|||.:.||||.:|||||
Mosquito   251 LRSSYEPVSFESMIKQTSPSAADQWEQRPEAAREPC-------LDIDQISEGEQKRLQPLLWLEL 308

  Fly   330 ATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRG 394
            |::||:|.|:|||||||||:||||||:||||:|||:||||||||.|::||||.|:.::.||..||
Mosquito   309 ASLFDKNHVTLDKRKPFKRKRKEEGNVFGVSLNALVRRDQQVTGEDTTLVPLVLQAILAELAVRG 373

  Fly   395 SREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
            :||||:||:.|||||||.||||:|..||..|:.:|.|.:.|.||:||:||||||||||||||.|:
Mosquito   374 AREEGILRVPGHKQKTEALYNEIEHNFYCKPEKIDPLIKKAGVHDLSALLKRWLRELPQPLLAND 438

  Fly   460 LIQLFYQCHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAP 524
            |:.||||.:.||..||..||::||.|||.|||||||.|||||..::.|:|:|||...|||||:||
Mosquito   439 LVHLFYQTNVLPPHDQYKALAVLCQLLPHENRNTLRELLSFFRRVVELQDLNKMTQQNVATIIAP 503

  Fly   525 SMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKTMMGKKGWHRHR 589
            |.||||::||.|.|.|..|||||||||.|||:||...:.|:.||..||  .|..|:.|.|    :
Mosquito   504 SFFPPRFVHPPDKNDIGAQVRMAAQCCHLTNVLITMSDSLWLVPQRLI--EQGKMINKNG----Q 562

  Fly   590 NSNEITAK-PSGKASNVGVGHDSTVINKYSTNLKHLHPFVI 629
            ...::|.| .:|..|.:.:...:.....:..:..|:|..||
Mosquito   563 PKRQLTRKAKNGSGSIIAINRSANSGGDFVFDTNHIHRLVI 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	137/219 (63%)
AgaP_AGAP008833	XP_319577.4	RhoGAP	335..553	CDD:295372	137/219 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	322	1.000	Domainoid score	I3275
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100333
Inparanoid	1	1.050	578	1.000	Inparanoid score	I2534
OMA	1	1.010	-	-		QHG27310
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		oto111326
Panther	1	1.100	-	-	LDO	PTHR14963
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15506
TreeFam	1	0.960	-	-
	13	12.940