DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and AgaP_AGAP003944

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_318402.5	Gene:	AgaP_AGAP003944 / 1278773	VectorBaseID:	AGAP003944	Length:	1908	Species:	Anopheles gambiae

Alignment Length:	319	Identity:	88/319 - (27%)
Similarity:	141/319 - (44%)	Gaps:	57/319 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 ISETDMKRLQTILWLEL-----ATIFDRNKVSLDKRKPFK--RRR---KEEGN---LFGVSINAL 364
            :|.|.:.|...|..|.|     .||:.|    |....||:  |||   ...||   |||..:..:
Mosquito   862 LSLTTLLRQSPIHQLALKVEPRGTIYLR----LRHTDPFQLFRRRGLPSLRGNVPALFGADLETV 922

  Fly   365 IRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQN----- 424
            :.|:.: .....:.||:.|.:.:.|:.|||....||.|:.|...|..|    |...|.:|
Mosquito   923 VTRESK-GAPGCAPVPIILRRCVEEVERRGLDIIGLYRLCGSATKKRL----LREAFERNSRAVE 982

  Fly   425 --PDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ----CHTLPSIDQMNA---LS 480
              |:::.:      ::.::.:||.:|||||:||.|..|.|:...    |  ||...:.||   ||
Mosquito   983 LTPEHVPD------INVITGVLKDYLRELPEPLFTKCLFQMTVDALGVC--LPDDPEGNAKLMLS 1039

  Fly   481 IL-CHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQV 544
            || |  ||..||.||..||...:::::..:.|||:...:||.:.    ||..:| |.:....|::
Mosquito  1040 ILDC--LPRANRATLVFLLDHLSLVVSAAERNKMSAQALATALG----PPLMLH-SASVGANEEI 1097

  Fly   545 RMAAQCCRLTNILILRGEKLFQVPNNLIVESQKTMMGKKGWHRHRNSNEITAKPSGKAS 603
            ..|.....|..:|     :::..|............|::|.......|:.:|..:||::
Mosquito  1098 DHAQPIAVLKYLL-----QIWPQPGTGTGAPTSGNTGRRGEPVEPRGNKASALQAGKSA 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	65/234 (28%)
AgaP_AGAP003944	XP_318402.5	PDZ_signaling	140..223	CDD:238492
		C2	775..874	CDD:175973	3/11 (27%)
		RhoGAP	915..1114	CDD:295372	63/223 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910