DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and AgaP_AGAP004772

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_318044.4	Gene:	AgaP_AGAP004772 / 1278454	VectorBaseID:	AGAP004772	Length:	782	Species:	Anopheles gambiae

Alignment Length:	576	Identity:	119/576 - (20%)
Similarity:	222/576 - (38%)	Gaps:	110/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FEQGLEVSKKDLEPILTTLSKPHA------EAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREF 117
            ||..:|: .:.|:.:.|.:...|.      ||..:|....|:.:::: :|.||.|.:....:|..
Mosquito   148 FETHVEI-LRILQELHTNMKTYHTLQTEAKEAEKKLRLAENQRMKLQ-QSVPKEKLERSKKYRLI 210

  Fly   118 DEQGTVTRSRSATPDSLDSLQIDEAW---TNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLR 179
            ::: .:.|....|...|.:|:....:   ...|..|....:.::....|.|::......:.:.|.
Mosquito   211 EKE-VLKRKNKYTDARLKALKAKNEYQLCLEASNTTIHKYFVEDLSDLIDCMDLGFHSVVSRALL 274

  Fly   180 RTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGY------SRIGTIQFPRNRSVSDPFCSI 238
            ...||             .|.||...|::|   |.|.:      ||....:|....|.:  |...
Mosquito   275 MHVSA-------------DQGRCRAVLHNA---ETLSHIVNSMDSRADKQKFLEQHSAA--FMIP 321

  Fly   239 GRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNV----LSFESICR--DSSSLDSCEVL 297
            .|.:....:.|...:.:|:..    .|.| .||:.:...|    :..|.|.:  :::.::..::|
Mosquito   322 KRLEFQGQDEDVEPELQKALH----QEME-SRLMQLEQRVNNLRMESEEIWKTLETAEINLLDIL 381

  Fly   298 DTCDIPST-------------------LFTDVVLISETDMKRLQ-------TILWLELATIFDRN 336
            :|.|...|                   |.:|...|.|..:.:::       .|..|:....:.||
Mosquito   382 NTKDYDCTSAFGDGAVAFQKPENTSVKLRSDKNEIEEFYITKIREYILATSRIARLDSKAEYLRN 446

  Fly   337 KVSLD--------------KRKPFKRRRKE-EGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKL 386
            .::.|              |||...|..|. ...|||.|:...:    :|:|.:   :||.:...
Mosquito   447 ALAKDSAIKTDTLTKSNVPKRKRIGRMNKSGRPKLFGGSLEEYL----EVSGEE---IPLIVRSC 504

  Fly   387 IGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLREL 451
            |..:...|...:|:.|:.|    :::..:..:..|.:..|.|..:...:.::.::.:||.:||||
Mosquito   505 IRVINLFGLHHQGIFRVSG----SQVEISNFKEAFERGDDPLAEMTDASDINSVAGVLKLYLREL 565

  Fly   452 PQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNV 515
            .:||........|.|...|.| .|.::.:......||......:|.|.:|.|.:....|.|.|:.
Mosquito   566 REPLFPLIYFDHFVQLAQLESKQDIVSGIRKFFQSLPKSVVVVIRYLFAFLNHLSEYSDENMMDA 630

  Fly   516 HNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNL 571
            :|:|....|::.|.    |.|.    :||:...|...|...:|:...:||  |.:|
Mosquito   631 YNLAICFGPTLMPA----PEDK----DQVQYQNQVNELIKNIIVHHAELF--PKDL 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/217 (24%)
AgaP_AGAP004772	XP_318044.4	F-BAR_srGAP	29..270	CDD:153340	23/124 (19%)
		RhoGAP_srGAP	480..667	CDD:239848	49/205 (24%)
		SH3_srGAP	722..774	CDD:212743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910