DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and AgaP_AGAP000870

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_316844.5	Gene:	AgaP_AGAP000870 / 1277386	VectorBaseID:	AGAP000870	Length:	1746	Species:	Anopheles gambiae

Alignment Length:	558	Identity:	121/558 - (21%)
Similarity:	186/558 - (33%)	Gaps:	154/558 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LQSNSQSIE--PEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLS-KPHAEAI 85
            ||.....:|  |.|:.||...|.|  ..|||.::...|...:......|   .||.| .|.|
Mosquito  1250 LQQQQAQLEHAPLAAPEDDSEEYE--DEAGYEQINDAFSDAVNNVASQL---FTTFSGGPGA--- 1306

  Fly    86 VQLVRTLNKTVR-------------------VRTKSRPKR-KPDIRDVFREFDEQGTVTRSRSAT 130
                   |...|                   .:||.|.:| |..|.::....|.:.
Mosquito  1307 -------NHGGRGGGGGGGGADSSGGSEMGTHKTKLRQRREKEQIFNIQENSDSES--------- 1355

  Fly   131 PDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRT--PSAPPKSGTYAD 193
                ||..::...:|:.       |.|        :.:..:.:.:...:||  |..|||
Mosquito  1356 ----DSSSLERKRSNDG-------YSK--------INRKAQPHKRHRKKRTAIPVQPPK------ 1395

  Fly   194 IFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSS 258
                      |||                  .|...|..|....:|.|...........||.|
Mosquito  1396 ----------IPL------------------GPFGSSTGDMMGGVGASGGPLGGMPIMYQKLK-- 1430

  Fly   259 EVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQT 323
                   ||.|..|. ..:..|.|.   |.||:|.....|.    |.:|.  ||...:|.::|.|
Mosquito  1431 -------NELGSGLE-KQDKPSQEP---DESSVDISSPRDN----SPIFG--VLPKGSDREKLIT 1478

  Fly   324 IL--WL--ELATIFDRNKVSLDKR---KPFKRRRKEEGNLFGVSINALIRRDQQ-----VTGTDS 376
            ..  |.  |:......:|.|.|.|   |...:..|..|.....:..|.....||     :..:|.
Mosquito  1479 KQKNWFGKEIDPAGKASKESKDARGSSKGASKNSKHNGAAAAAAAAAAAAALQQSSLASLKQSDK 1543

  Fly   377 -SLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHEL 440
             .|||||:||.:..:.:.|...||:.|:.|::...:||..:.......:.:.||     ..|:.:
Mosquito  1544 VPLVPLFVEKCVKFIEQEGLDSEGIYRVPGNRTHVDLLNQKFAEESDVDIEKLD-----IPVNAV 1603

  Fly   441 SSLLKRWLRELPQPLLTNELIQLFYQ---CHTLPSIDQMN------------ALSILCHLLPPEN 490
            ::.||.:..:..:.|.:.|::....:   ...|.||..:|            ||..|.:.|||.|
Mosquito  1604 ATALKDFFVKRLKGLFSAEMMSELEEIAGSRPLQSITSLNMEVKTDRSCRLIALRGLLNKLPPNN 1668

  Fly   491 RNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFP 528
            ...|..:...|..:.....:|.|:..|:|....|::.|
Mosquito  1669 FAILSYIFQHFVRVSENSKLNSMDSKNLAICWWPTLLP 1706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	44/194 (23%)
AgaP_AGAP000870	XP_316844.5	P-loop_NTPase	<148..240	CDD:304359
		RhoGAP-FF1	254..333	CDD:293121
		RhoGAP	1547..1736	CDD:295372	39/165 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910