DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and AgaP_AGAP000126

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_311021.5	Gene:	AgaP_AGAP000126 / 1272143	VectorBaseID:	AGAP000126	Length:	1735	Species:	Anopheles gambiae

Alignment Length:	970	Identity:	175/970 - (18%)
Similarity:	276/970 - (28%)	Gaps:	422/970 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TDLHHSDDQDFSEFLNEYYLQ---SNSQSIEPEASYEDGEME-----AEWLVSAGYP-ELTKPFE 60
            ||..|:|.:::...::|...:   |.||...||..||:.|:.     ||.|.....| :|.:|..
Mosquito   565 TDRRHADGEEYEALVDEEEEEEALSVSQISTPEPFYENSELPSAVPLAEQLAKRRTPHDLLQPVP 629

  Fly    61 QGL----------EVSKKDL----EPILT----TLSKPHA-EAIVQ--------------LVRTL 92
            .|.          |||..|:    :|:.:    .:|...| |||::              |:..|
Mosquito   630 IGELDVQLRHDYDEVSIADIIDEFDPLASGTTAVVSVGAALEAIIEQDGSEGAPPGGNLALIENL 694

  Fly    93 -------NKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATP------------------- 131
                   ....||.....|:|.|............||.:.:.:..|
Mosquito   695 LGEESYSRMPKRVSRDGPPERCPRPPQRSDSLFISGTASSAETGAPPPDRAVPAKPARRKSNRPS 759

  Fly   132 -------------------DSLDSL-QIDE-------AWTNNSLPTFVN-------VYEKNTET- 161
                               .|:|:| :::|       |.|.:..|...|       .|.:..:|
Mosquito   760 RPADQTVSQIIHQNLNLPTGSVDNLVELEERLIEPHLARTEDEPPIGGNGDEQVDLSYSRGPQTS 824

  Fly   162 --------------AIQ--------CVEQSNEIYLK---------QNLRRTP-----SAPPKSGT 190
                          ||.        .|:..||.|.:         |.:.:||     |:...:||
Mosquito   825 WYVEREGPAGKGEIAINTNHFKKRATVDPVNEHYPQGGSAGRDAVQKVTKTPFMAGSSSAASTGT 889

  Fly   191 YADIFRGSQVRCD-----IPLYSADGVELLGYSRIG----------------TIQFPRNRSVSDP 234
            .|....|..:..|     :|.|         :..||                |....::.||:..
Mosquito   890 VAPAEEGDALIDDARASYLPTY---------FEAIGGTDPLFERGLAATPTTTTTATKSPSVATK 945

  Fly   235 FCSIGRSKESRSENDARSQKKKSSEVLSASE------------NECGRLLPMP------------ 275
            ..:..:.|.|.|:.|:.|.....|.||:..|            :..|.:|..|
Mosquito   946 LLNALKRKPSFSKGDSASSSATGSTVLTTLEMVPKPKLTERLISHKGHVLKFPSGKIADVLNELA 1010

  Fly   276 ----------------------------YNVLSFESICR-------------------------- 286
                                        .::||.:||.:
Mosquito  1011 PRSVVLRERIFQTYLDPQQTLPKEAIHLRHILSVQSILQHKFAGEGRLDLHCFEVVLGVPKGAGS 1075

  Fly   287 --------DSSSLDSCEVLDTCDIPSTLFT--DVVLISETDM----KRLQTILWLE--LATIFD- 334
                    .||:|.:..:....|:..|..|  :|.|..::.|    ||....||:.  |.::.|
Mosquito  1076 AGSAGGGAGSSALAAASMSTHPDLLITSGTSGNVKLTRQSYMFGTHKRSDRNLWMAKILQSVTDV 1140

  Fly   335 -------------------RNKVS---------LDKRK----PFKRRRKEE-------------- 353
                               :..||         |.||:    .|...|.||
Mosquito  1141 FGGEGELLREFLRAGWCYVKKSVSAGWAGAWLLLAKRRLYLYSFNEHRLEELDLRKARCIGVVEN 1205

  Fly   354 -----GNLF---GVSI---------------------------------NALIRRDQQVTGTDSS 377
                 |||:   |.|:                                 |......||:|..|
Mosquito  1206 EPATIGNLYVEGGPSLFIDCPPYTTLYFVMGSPRETHIWLKVIRQVAHKNGPTLHSQQLTRGD-- 1268

  Fly   378 LVPLFLEKLIGELLRRGSREEGLLRIGGHK-----------------QKTELLYNELESTFYQNP 425
             ||:.::|.|..:...||..||:.|..|.:                 |.|...|||
Mosquito  1269 -VPVLIDKCINFIYAHGSMSEGIYRKSGSQSAVVRILQLFNEDAFSVQLTRNDYNE--------- 1323

  Fly   426 DNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSI-----LCHL 485
                        ::::..||:::||||.... ......|....:|........|.|     |...
Mosquito  1324 ------------YDVAGALKKFVRELPGSFF-GSYAASFVAIGSLSGSADGQQLKIESYRQLLER 1375

  Fly   486 LPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRY----------IHPSDNNSI 540
            ||.....||:.||.....|.:|:..|:|.|.|:|.|....:.....          .|..|.:.:
Mosquito  1376 LPRLEYCTLKKLLGHLAFIASLEAHNRMGVPNLAMIWGSVLLANASQNTVQEGRGGYHQQDADVV 1440

  Fly   541 AEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKTMMGKKGWHRHRNSNEITAKPSG 600
            |:.:|:.:              .||.|..:.:.:.|..:...|.:|....:.....|.||
Mosquito  1441 ADLIRLYS--------------SLFPVDADELYKEQLMLSVLKKYHAAAENLSDAVKHSG 1486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	55/287 (19%)
AgaP_AGAP000126	XP_311021.5	PH	1151..1253	CDD:214574	14/101 (14%)
		RhoGAP	1255..1447	CDD:295372	49/216 (23%)
		UBQ	1521..1593	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910