DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and DLC1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001335010.1	Gene:	DLC1 / 10395	HGNCID:	2897	Length:	1528	Species:	Homo sapiens

Alignment Length:	763	Identity:	156/763 - (20%)
Similarity:	271/763 - (35%)	Gaps:	223/763 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNTDLHHSDD--------QDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPF 59
            |:::|..:||        ::.|.|  .:.::.:.::.:.:.......||:..|.|:.:.:...|.
Human   626 SSSNLAGNDDSFGSLPSPKELSSF--SFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPS 688

  Fly    60 EQGLEVSKKDL-----EPILTTLSKPHAEAI------VQLVRTLNKTVRVRTKSRPKRKPDIRDV 113
            :.||.:|...|     |..|..|:.....|:      |.:||..:.:...:|.|...:.    :.
Human   689 KLGLIISGPILQEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQS----ET 749

  Fly   114 FREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNL 178
            .........|||:||.:..:.......|.:...:..||.||.|:|.:.. :...:....|:.::
Human   750 SSAVSTPSPVTRTRSLSACNKRVGMYLEGFDPFNQSTFNNVVEQNFKNR-ESYPEDTVFYIPED- 812

  Fly   179 RRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFP------RNRSVSDPFCS 237
             ..|...||:.|     .||        :|..|.......|.|:...|      |..|...|
Human   813 -HKPGTFPKALT-----NGS--------FSPSGNNGSVNWRTGSFHGPGHISLRRENSSDSP--- 860

  Fly   238 IGRSKESRSENDARSQKKK--------------SSEVLSASENECGRLLP----MPYNVLSFESI 284
                ||.:..|.:.|...:              ||..|:..|||  .:.|    :.|:|...:.|
Human   861 ----KELKRRNSSSSMSSRLSIYDNVPGSILYSSSGDLADLENE--DIFPELDDILYHVKGMQRI 919

  Fly   285 -----------------------CRDS---------------SSLDSC-----EVLDTCDIP--- 303
                                   |..|               |.|||.     |..:..:||
Human   920 VNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDNDRTTPSDLDSTGNSLNEPEEPSEIPERR 984

  Fly   304 -----------------------------STLFTDVVLISETDMKRLQTILWLELATIFDR---- 335
                                         :::...:...|...|..||....|:|..:.::
Human   985 DSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPS 1049

  Fly   336 NKVSLDKRKP-FKRRRK----EEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGS 395
            ||.......| |.:|.|    ::.::|||.:...::|..|.       :|..:::.:..|.....
Human  1050 NKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQP-------LPQSIQQAMRYLRNHCL 1107

  Fly   396 REEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNL-FRTATVHELSSLLKRWLRELPQPLLTNE 459
            .:.||.|..|.|.:.:.|..       .|...:|.: :...:.::::.:||::.|:||:||:||:
Human  1108 DQVGLFRKSGVKSRIQALRQ-------MNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNK 1165

  Fly   460 LIQLFYQCHT-LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMA 523
            |.:.|.|.:. :|...::.|:.....|||.|||..|::||.|.:.:......|:|...|:|..:|
Human  1166 LSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLA 1230

  Fly   524 PSMF----------PPRYIHPS-----------DNNSIAEQ--VRMAAQCCRLTNILILRGEKLF 565
            ||:|          .||.:...           :.|..|.|  ..|.|:|           :|||
Human  1231 PSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAEC-----------KKLF 1284

  Fly   566 QVPNNLIVESQKTMMGKKGWHRHRNS-NEITAKPSGKASNVGVGHDST 612
            |||..:              .|.||| .|...||....:...:|:|.:
Human  1285 QVPEEM--------------SRCRNSYTEQELKPLTLEALGHLGNDDS 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	61/244 (25%)
DLC1	NP_001335010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..310
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..436
		SAM_DLC1	454..513	CDD:188990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..617
		Focal adhesion-targeting (FAT)	710..884		38/200 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..764		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..876		11/53 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..990		9/61 (15%)
		Polybasic cluster (PBR)	1051..1073		5/21 (24%)
		RhoGAP_DLC1	1072..1290	CDD:239840	61/242 (25%)
		START_STARD12-like	1315..1518	CDD:176917	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810