DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap39

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_009293293.2	Gene:	arhgap39 / 101884459	ZFINID:	ZDB-GENE-041014-247	Length:	967	Species:	Danio rerio

Alignment Length:	567	Identity:	117/567 - (20%)
Similarity:	195/567 - (34%)	Gaps:	199/567 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHHSDDQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAG-YPELT--KPFEQGLEVSKK 68
            ||.|..:|... .:::....|::::.|.|             |.| :||.|  ||      .|:.
Zfish   532 LHPSQSEDLGA-CSQFEASRNARNMMPSA-------------SCGIFPEFTLRKP------SSET 576

  Fly    69 DLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDI----RDVFRE----FDEQGTVTR 125
            |:|...:.....|.:.:.:  |.::....:...|.|.:||.|    |.|.||    |....|...
Zfish   577 DIENWASKHFNKHTQGLFR--RKVSIANMLAWSSEPIKKPMIMTSDRTVKREAVDLFKLIQTYMG 639

  Fly   126 SRSATPDSLD-SLQID-EAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRR-------- 180
            .|.|..|.|. :|::. ..|:...|         ..|..||...|:.|.:...:|:|
Zfish   640 DRRAKADPLAVALEVAVRGWSCQGL---------RDELYIQLCRQTTENFRYDSLQRGWELMAIC 695

  Fly   181 ---TPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSK 242
               .|..|    .:.:...|...|...||....||.:..|::               :|.....|
Zfish   696 LAFFPPTP----RFHNYLEGYIYRHMDPLNDTKGVAISSYAK---------------YCYRKLQK 741

  Fly   243 ESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDS---SSLDSCEVLDTCDIPS 304
            .:.| ...:..||.|.|.::.:.|                :|.|.|   |||:.
Zfish   742 AALS-GAKKGLKKPSVEEIAYARN----------------AIFRPSMFGSSLEE----------- 778

  Fly   305 TLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQ 369
                  |:..:.:....|.:.|::                                    .|..:
Zfish   779 ------VMAMQKERYPDQQLPWVQ------------------------------------TRLSE 801

  Fly   370 QVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRT 434
            :|.|.:                  |.:.||:.|:.|...:...|  :|:...::.|..|::
Zfish   802 EVLGLN------------------GDQTEGIFRVPGDIDEVNAL--KLQVDQWKVPTGLED---- 842

  Fly   435 ATVHELSSLLKRWLRELPQPLLTNELIQLFY-QCHTLPSIDQMN------ALSILCHLLPPENRN 492
              .|..:||||.|.|||.:|::.:|    || ||       .||      |::::.: ||..|:.
Zfish   843 --PHIPASLLKLWYRELEEPVIPHE----FYEQC-------VMNYDSPAAAVNVVLN-LPHINKL 893

  Fly   493 TLRSLLSFFNIIINLKDIN--KMNVHNVATIMAPSMF-----PPRYI 532
            .|..|:.|..:......::  ||:|.|:|.:|||:..     .||.|
Zfish   894 VLCYLIRFLQVFAQPASVSMTKMDVSNLAMVMAPNCLRCQSDDPRVI 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	47/191 (25%)
arhgap39	XP_009293293.2	WW	4..>72	CDD:320787
		MyTH4	650..759	CDD:307090	26/137 (19%)
		RhoGAP_KIAA1688	772..957	CDD:239854	53/260 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910