DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap21a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001340279.1	Gene:	arhgap21a / 101883923	ZFINID:	ZDB-GENE-090918-5	Length:	1939	Species:	Danio rerio

Alignment Length:	693	Identity:	136/693 - (19%)
Similarity:	241/693 - (34%)	Gaps:	162/693 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSNTDLHHSDDQDFSEFLNEYYLQSNSQS-----------------------------IEPEAS 36
            ::||.|    |..|...|::|....||...                             |..:.|
Zfish   789 ISSNLD----DSLDSIPFIDEPSSSSNDHDTTHIPASAVISSTPVITTIPPSPTSPTPVIRRQLS 849

  Fly    37 YEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTK 101
            ::...:....|.|....|.::.|::||:..:::...  .::...|.      .:.|.|.|...::
Zfish   850 HDQDSLRLTILESDSKTERSRSFDEGLDNYREERRG--RSIKHTHG------FKGLRKAVDRCSE 906

  Fly   102 SRPKRKPDIRDVFREFDEQGTV-------TRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNT 159
            ....|:....|||.:..::|::       .:|:..........||......:.|..:.:..:..|
Zfish   907 DSGSRRDSNSDVFTDATKEGSLYFRQLNSEKSKRVGSSMRSWKQIYAVLRGHCLYLYKDKRDGQT 971

  Fly   160 ETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVR-----CDIPLYSADGVELLGYSR 219
            ....|..|:...|.:|..|...        :|:|..|.:.:|     |:....:.|..|:|.:.|
Zfish   972 NANSQIEEEPLPISIKACLIDI--------SYSDTKRKNVLRLTTSDCEYLFQAEDREEMLSWIR 1028

  Fly   220 IGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESI 284
            :  ||                   ..|..|..:....|:::::....|...|:..|    |.::.
Zfish  1029 V--IQ-------------------ENSNLDEENATVTSTDLINRKIKEYNTLMSPP----SSKTE 1068

  Fly   285 CRDSSSLDSCEVLDTC------------DIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNK 337
            ....:|..|..:..|.            ..|:         .|.|.|.:..          |...
Zfish  1069 PSPKASRQSLSIRQTLLGGKGENKATSPHSPN---------KEHDRKAMHK----------DETS 1114

  Fly   338 VSLDK-----------RKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELL 391
            ...||           ||||: ::...|..|||      |.|......::..|||.:|.....:.
Zfish  1115 PPKDKGTWRKGIPGLMRKPFE-KKPSPGVTFGV------RLDDCPPAQNNRFVPLIVEVCCNLVE 1172

  Fly   392 RRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLL 456
            .||....|:.|:.|:.....::..||.:....:.|..|:.::...|  :|||||.:.|:||:||.
Zfish  1173 ERGLEYTGIYRVPGNNAAISIMQEELNNKGMADIDIQDDKWKDLNV--ISSLLKSFFRKLPEPLF 1235

  Fly   457 TNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVAT 520
            |||....|...:.:.. ::::..|..|.|.||..:..||:.|.:....:....:.|||...|:|.
Zfish  1236 TNERYADFIDGNRIEDPVERLKVLKRLLHELPDHHYETLKFLSAHLKTVAENSEKNKMEPRNLAI 1300

  Fly   521 IMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF----------QVPNNLIVES 575
            :..|::     :..|::|.......|..| .::...||...:..|          .|.....|||
Zfish  1301 VFGPTL-----VRTSEDNMTHMVTHMPDQ-YKIVETLIQHYDWFFTEEGDNEPTTTVQEESAVES 1359

  Fly   576 QK--------TMMGKKGWHRHRNSNEITAKPSGKASNVGVGHD 610
            |.        |.:|:.|......|:..|:..:....:.|.|.|
Zfish  1360 QPVPNIDHLLTNIGRTGTSPGEVSDSPTSDSAKSKGSWGSGKD 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	57/230 (25%)
arhgap21a	NP_001340279.1	PDZ_signaling	53..128	CDD:238492
		PH_ARHGAP21-like	923..1037	CDD:269955	23/142 (16%)
		RhoGAP_ARHGAP21	1143..1339	CDD:239860	53/209 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910