DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and arap2

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_031751219.1	Gene:	arap2 / 100494395	XenbaseID:	XB-GENE-991948	Length:	1566	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	91/457 - (19%)
Similarity:	155/457 - (33%)	Gaps:	142/457 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 TVTRSRSATPDSLDSLQIDEAW---TNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPS 183
            |:.|.....|      ::.:.|   .||    |:..||..|......|...:||.   :|...||
Frog   806 TINRKSKEVP------EMKQWWCTIENN----FLKYYENETAPVADGVIDLSEII---SLVIHPS 857

  Fly   184 APPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSEN 248
            ....:|..|..|....:...:.|:.|:.|                              |||.|
Frog   858 DFSSNGMAAFTFEIYFLSERMFLFGAENV------------------------------ESRRE- 891

  Fly   249 DARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSL--------------------DS 293
            .:|:..|..:..:.      |.||.:.:|||.:.:. ::||||                    |.
Frog   892 WSRAIAKNFTPAVE------GYLLELDFNVLGYLNY-KNSSSLSQWKKGWFALEKARLHYCNKDD 949

  Fly   294 CEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLF- 357
            |...||                ..:|:||     ||..    |..:|:..|.......|.|..|
Frog   950 CGNADT----------------IQLKKLQ-----ELTA----NSSTLNGEKGNILLLVENGRTFY 989

  Fly   358 --------------------GVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGL-L 401
                                |...|||  :|||::..:   :|:.:...|..:.:.|...:.| |
Frog   990 IHGHTMLDFTVWHSAIEKAAGTDGNAL--QDQQLSKNN---IPIIVNSCIAFVTQYGLGSKSLYL 1049

  Fly   402 RIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ 466
            :.|...|..|||     ..|.::..::........:.:::.:||.:..|:...|||.||..
Frog  1050 KNGNPLQVRELL-----EEFKKDARSIKLKVGKHQLEDVTDVLKYFFYEIDDALLTKELYP---- 1105

  Fly   467 CHTLPSID------QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPS 525
             :.:.::|      ::.....:...:|..|:.||.:|:.....|....|||.::...:|...:..
Frog  1106 -YWISALDIRNEQERVKKYKTVISTVPALNKATLAALIEHLFRIQKCFDINHLDTQTLAKAFSSC 1169

  Fly   526 MF 527
            :|
Frog  1170 LF 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	39/200 (20%)
arap2	XP_031751219.1	SAM_superfamily	10..71	CDD:417767
		PH-like	394..481	CDD:418428
		PH-like	495..579	CDD:418428
		ArfGap_ARAP2	584..704	CDD:350081
		PH-like	789..900	CDD:418428	28/137 (20%)
		PH-like	913..1008	CDD:418428	22/120 (18%)
		RhoGAP_ARAP	1012..1191	CDD:239850	37/175 (21%)
		Ubiquitin_like_fold	1223..1320	CDD:421700
		PH-like	1333..1439	CDD:418428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910