DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and dlc1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_031751274.1	Gene:	dlc1 / 100488460	XenbaseID:	XB-GENE-482055	Length:	1116	Species:	Xenopus tropicalis

Alignment Length:	873	Identity:	172/873 - (19%)
Similarity:	279/873 - (31%)	Gaps:	375/873 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EMEA----EWLVSAGYPELTKPFEQ---GLEVS--KKDLEPILTTLSKPHAEAIVQLVRTLNKTV 96
            |:||    :||.:||:|:..:.:|.   .:::|  |||.:    .|.:...||:.:.:.||||..
Frog    39 EIEAKEACDWLRAAGFPQYAQLYEDLLFPIDISSVKKDHD----FLDRDAIEALCRRLNTLNKCA 99

  Fly    97 RVRTKSRPKRKPD-----------------IRDVFR-----EFD----EQG-------------- 121
            .::.:..|.||..                 .||..|     ||:    .||
Frog   100 VMKLEISPNRKRSEESDEDEPCAISGKWTFQRDSKRWSRLEEFEVFPLTQGPKALLSDAHQLGNA 164

  Fly   122 -----------------------------------TVTRSRSATP--DSLDSLQIDEAWTNNSLP 149
                                               :.||:.|.|.  .|.:.:..|:::.:...|
Frog   165 ISQDSILTDLSEHQDVVSITSTSSESPRAHLPSDASTTRTNSVTSICSSGNFIANDDSFGSLPSP 229

  Fly   150 TFVNVY-------EKNTET---------------------------------------------- 161
            |.::.:       :||:::
Frog   230 TELSTFNFTSKANQKNSKSRTKSLLKRMESLKIKSSNSKKKSHSKLGLIISEPILQEAVDDDKLK 294

  Fly   162 AIQCVEQS----NEIYLKQ-------NLRRTPSAPPKSGTYADIFRGSQV---RCDIPLYSADGV 212
            .:.|||.|    |.|...:       |..:|.|:..:|.|.:.:...|.|   |.....:...|:
Frog   295 QLNCVEISSLNGNHINAPKVRKRSTSNSTQTSSSSSQSDTSSAVSTPSPVTRTRSLSACHKRVGM 359

  Fly   213 ELLGYS---------------------------------RIGTIQFPR-----NRSVSDPFCSI- 238
            .|.|:.                                 :.||  ||:     |.|.||...|:
Frog   360 YLEGFDPFNQSTFSDVLEQNYKNQRTFGEDAVFFIPEDHKPGT--FPKALSNGNLSPSDSSPSVT 422

  Fly   239 -------GRSKES-RSENDARSQKKKSSEVLSASENEC--------------GRLL--------- 272
                   |....| |.||...|.|   |.|.|...|.|              |.||
Frog   423 WRTGSFHGHDNLSFRRENSISSCK---SSVSSQRRNSCCSEGSRLSIYDNVPGTLLYSSNSDLAD 484

  Fly   273 -----------PMPYNVLSFESICR----------DS-SSLDS------------------CEVL 297
                       .:.|:|...:.|..          || |:|||                  |..|
Frog   485 LENEDIFPELDDILYHVKGMQRIVNQWSEKFYDEGDSDSALDSVSPCPSSPKQIHLDIDNDCNAL 549

  Fly   298 DTCDIPSTLFTD---VVLI-------------------------------------------SET 316
            ...|.....|.|   ..:|                                           |.|
Frog   550 SDLDSTGNSFNDCEEATVIQARRDSGVGASLTRTNRHRFRWHSFQSSHRPSLSSASLQMNCQSVT 614

  Fly   317 DMKRLQTILWLELATIFDR----NKVSLDKRKP-FKRRRK----EEGNLFGVSINALIRRDQQVT 372
            .:..||....|:|..:.::    ||.......| |.:|.|    ::.|:|||.:...::|..|.
Frog   615 QINLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRVKVPDYKDRNVFGVPLAINVQRTGQP- 678

  Fly   373 GTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATV 437
                  :|..::..:..|..:...:.||.|..|.|.:. |...|:..   .|.|:|  .:...:.
Frog   679 ------LPQSIQLAMRYLRSQCLDQVGLFRKSGVKSRI-LALREISE---NNNDSL--TYEGQSA 731

  Fly   438 HELSSLLKRWLRELPQPLLTNELIQLFYQCHT-LPSIDQMNALSILCHLLPPENRNTLRSLLSFF 501
            ::::.:||::.|:||:||||::|.:.|.|.:. :|...::.|:.....|||.|||..|::||.|.
Frog   732 YDVADMLKQYFRDLPEPLLTSKLSETFLQIYQYVPKEQRLQAIKAAIMLLPDENREVLQTLLYFL 796

  Fly   502 NIIINLKDINKMNVHNVATIMAPSMF----------PPRYIHPS-----------DNNSIAEQ-- 543
            :.:....|.|:|...|:|..:|||:|          .||.:|..           :.|..|.|
Frog   797 SDVAAAVDENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMHRKQSLGKPDQKDLNENLAATQGL 861

  Fly   544 VRMAAQCCRLTNILILRGEKLFQVPNNL 571
            ..|.|:|           :|||::|..:
Frog   862 AHMIAEC-----------KKLFKIPEEM 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	63/240 (26%)
dlc1	XP_031751274.1	SAM_superfamily	39..102	CDD:417767	20/66 (30%)
		RhoGAP_DLC1	660..878	CDD:239840	64/241 (27%)
		SRPBCC	908..1106	CDD:417480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910