DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap23a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_003198196.2	Gene:	arhgap23a / 100006233	ZFINID:	ZDB-GENE-121019-1	Length:	1845	Species:	Danio rerio

Alignment Length:	558	Identity:	103/558 - (18%)
Similarity:	206/558 - (36%)	Gaps:	121/558 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPK 187
            :|..||.:.|...:...:|....:.||..|..:  .||.::..:..:.|...|    |..::...
Zfish   871 ITTERSKSCDEGLNAYREEGRVFSRLPKRVKSF--FTEGSLDSLGAAEEARSK----RHSTSELG 929

  Fly   188 SGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARS 252
            :.:|:|:.|...:... .:::..|      .::|:..:|..|     ..|:.|:.......|.|.
Zfish   930 NISYSDVKREGWLHFK-QIHTEKG------KKVGSAIWPWRR-----VFSVLRTHSLFLYKDKRE 982

  Fly   253 QKKKSSEVLSASENE-----CGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVL 312
            ...|.:::...:|:|     .|.|:.:.|:....:...| .::.|.||.|...:....:...:.:
Zfish   983 AVLKGAQLGGGAEDEQPISIRGCLVDIAYSETKRKHALR-LTTQDFCEYLLQAEDREDMLEWIRV 1046

  Fly   313 I---SETDMKRL----QTILWLELATIFDRNKVSLDKRKP------------------------- 345
            |   |:||.:.|    |.::..:|.   |..|.|....||
Zfish  1047 IRDNSKTDNEELGFSRQALINKKLN---DYRKQSPTGNKPDSSPRVHRMTFLLSKPDNSAPPRSP 1108

  Fly   346 -------------------FKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELL 391
                               .|:.:|.....|||      |.:......::..:|..:|...|.:.
Zfish  1109 KHEAKDESSPPKSPWGINIMKKSKKAGPKAFGV------RLEDCQPAVNNKFIPQIVEICCGLVE 1167

  Fly   392 RRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLD-NLF--RTATVHELSSLLKRWLRELPQ 453
            ..|....|:.|:.|:......|..:|..       .:| |:.  :...::.:|||||.:.|:||:
Zfish  1168 DMGLEYTGIYRVPGNNAVVSSLQEQLNK-------GVDINITEEKWQDLNVVSSLLKSFFRKLPE 1225

  Fly   454 PLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHN 517
            ||.|::....|...:.:.:. |::..:..|...||....:||:.|:.....:.:..:.|||...|
Zfish  1226 PLFTDDKYNDFIDANRMENASDRLRTMKKLIRDLPDHYFHTLKFLVGHLKTVADHSEKNKMEPRN 1290

  Fly   518 VATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKTMMGK 582
            :|.:..|::     :..|::| :.:.|.......::...||......|....:   :.:||.:
Zfish  1291 LALVFGPTL-----VRTSEDN-MTDMVTHMPDRYKIVETLIQHYTWFFCEEQD---KDEKTPV-- 1344

  Fly   583 KGWHRHRNSNEITAKPS--------GKASNVGVGHDST 612
                   ::.::...|:        |:...:|...|||
Zfish  1345 -------DTEDVQPAPNIDHLLSNIGRTGMLGEASDST 1375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	46/223 (21%)
arhgap23a	XP_003198196.2	PDZ_signaling	116..223	CDD:238492
		PH	936..1052	CDD:278594	21/128 (16%)
		PH_ARHGAP21-like	938..1054	CDD:269955	22/128 (17%)
		RhoGAP_ARHGAP21	1138..1332	CDD:239860	45/212 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910