DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and stard13b

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005157695.1	Gene:	stard13b / 100005208	ZFINID:	ZDB-GENE-050506-146	Length:	1487	Species:	Danio rerio

Alignment Length:	581	Identity:	122/581 - (20%)
Similarity:	229/581 - (39%)	Gaps:	170/581 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 RVRTKSRPKRKPDIRDVFREFDE----------QGTVTRS---RSATPDSLDSLQIDEAWTNNSL 148
            ||..::|       |:.||.:::          .||..::   .|.:|.:..|:.    |.:.|:
Zfish   741 RVAEQNR-------RNEFRSYEDLVVHIPKDHKPGTFPKALSIESLSPSTATSIN----WHSASM 794

  Fly   149 PTFV----NVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYA-----------DIF--- 195
            .:.|    ::.|....|  ||..:.:.|.:..|:       |.|..||           |:|
Zfish   795 DSDVQRPPSIKEPRPVT--QCCTRGSRISIYDNV-------PGSHLYASTGDLIDLEKEDLFPHL 850

  Fly   196 -----------------------------RGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSV 231
                                         :| ||..|:     :|.:.|..|...|:.| ...||
Zfish   851 DDILQHVNGLQQIVDHWSKNVLPNSENAGKG-QVDLDV-----EGQDDLQSSSQITLDF-EGHSV 908

  Fly   232 SDPFCSIGRSKESRSENDARS-QKKKSSEVLSASENECGRLLPMPYNVL--SFESICRDSSSLDS 293
            .:     |::..|..|.|..| .:.:|:.:....::..|..|..|..:.  ||:...|.|.|:.|
Zfish   909 LE-----GQATPSDVERDGVSLNETESTGMRERRDSGVGASLTRPKRLRWPSFQISNRLSHSVAS 968

  Fly   294 CEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKR------KPFKRRRK- 351
            .::...              |...:..||....|.|..|.::..:| :|.      ..|.:|.|
Zfish   969 LQITSQ--------------SAAQLSLLQKFSLLRLTAIMEKYSMS-NKHGWTWSVPKFMKRMKV 1018

  Fly   352 ---EEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELL 413
               ::.|:|||.:...::|..|.       :||.:::.:..|..:...:.||.|..|.|.:.:.|
Zfish  1019 PDYKDKNVFGVPLIVHVQRFGQP-------LPLGMQQALRYLRSQCLDQVGLFRKSGVKSRIQAL 1076

  Fly   414 YNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHT-LPSIDQMN 477
            ....||    :||:::  :...:.::::.::|::.|:||:||||::|.:.|...:. :|...::.
Zfish  1077 RQMNES----SPDDVN--YEDQSAYDVADMVKQFFRDLPEPLLTSKLGETFLHIYQYVPKEQRLQ 1135

  Fly   478 ALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMF----------PPRYI 532
            |:.....|:..|||..|::||.|.:.:.:....|:|...|:|..:|||:|          .||.:
Zfish  1136 AVQAAIMLMSDENREVLQTLLCFLSDVTSSVQENQMTPMNLAVCLAPSLFHLNILKKDNLTPRAM 1200

  Fly   533 HPS-------------DNNSIAEQ--VRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKT 578
            |..             :.|..|.|  ..|..:|           .:||::|:.::.:|:.:
Zfish  1201 HMQKKYATGRPDQKDLNENLAATQGLAHMITEC-----------NRLFEIPHEMVTQSRNS 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	57/245 (23%)
stard13b	XP_005157695.1	SAM_DLC2	419..482	CDD:188991
		SAM	423..482	CDD:197735
		RhoGAP_DLC1	1023..1243	CDD:239840	58/243 (24%)
		SRPBCC	1275..1478	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910