DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap24

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_001339010.2	Gene:	arhgap24 / 100005116	ZFINID:	ZDB-GENE-091118-20	Length:	752	Species:	Danio rerio

Alignment Length:	424	Identity:	100/424 - (23%)
Similarity:	165/424 - (38%)	Gaps:	120/424 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 IFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSS 258
            :.||.|:     .|..|..|.   ..:|||..|.||....|         |..|...    |...
Zfish    45 VLRGDQL-----YYYKDEDET---KALGTIFLPGNRVTEHP---------SNGEEGG----KFLF 88

  Fly   259 EVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDM----K 319
            ||:...:.|                  |.:|:.::..::.:              ::.||    |
Zfish    89 EVIPGGDRE------------------RMTSNHETYLLMAS--------------TQNDMEDWVK 121

  Fly   320 RLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLE 384
            .::.::|                 .||      .|.:||..:...:|.:::.   .:.:.|:.:|
Zfish   122 SIRRVIW-----------------APF------GGGIFGQKLEETVRYERRY---GNKMAPMLVE 160

  Fly   385 KLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF--YQNPD---NLDNLFRTATVHELSSLL 444
            :.:..:...|.|||||.|:.|...    |..||:..|  .:.|.   |.|       ||.::|||
Zfish   161 QCVDFIRNWGLREEGLFRLPGQAN----LVKELQDAFDCGEKPSFDCNTD-------VHTVASLL 214

  Fly   445 KRWLRELPQPLLTNELIQLFYQCHTLPSIDQ---MNALSILCHLLPPENRNTLRSLLSFFNIIIN 506
            |.:|||||:|::.....:.|..|..|.|.||   |..|......||..|.|.|:.:..|.:.:.:
Zfish   215 KLYLRELPEPVIPFSKYEEFLACTKLLSKDQEAGMKELRRQVEALPVVNYNLLKYICKFLDEVQS 279

  Fly   507 LKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF------ 565
            ...:|||:|.|:||:..|::..|:.   .|..:|.|...:..|   |..:||.:.:.||
Zfish   280 YSGVNKMSVQNLATVFGPNILRPKV---EDPVTIMEGTVLVQQ---LMAVLIGQHDVLFPAEEEH 338

  Fly   566 ----QVPNNLIVESQKTMMGKKGWHRHRNSNEIT 595
                ::.||...|:||  ....|..:::.:|..|
Zfish   339 SSTLELVNNNNNETQK--QPTNGQLQNKENNNTT 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	67/237 (28%)
arhgap24	XP_001339010.2	PH-like	21..134	CDD:302622	27/164 (16%)
		PH	23..127	CDD:278594	24/134 (18%)
		RhoGAP_ARHGAP22_24_25	134..332	CDD:239855	62/217 (29%)
		BAR	<649..737	CDD:299863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910