DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap18

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_001343601.7	Gene:	arhgap18 / 100004252	ZFINID:	ZDB-GENE-070502-1	Length:	672	Species:	Danio rerio

Alignment Length:	599	Identity:	156/599 - (26%)
Similarity:	258/599 - (43%)	Gaps:	134/599 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DDQDFSEFLNEYYLQSNSQSIEPEASY-----EDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDL 70
            |:|...::..|..:...|...|.:...     ::||.|..||:.||...|   |:|... ..:|.
Zfish    91 DEQAMVDYFKEVEIIQRSGDAETQEELQLKVADEGEQEEAWLMEAGLATL---FDQSAS-DGEDS 151

  Fly    71 EPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLD 135
            ..:|:||::..|.|:.:.|.||.:|:|.|.|  |...||:|::|:   ...|...|:.
Zfish   152 IALLSTLTRTQAAAVERRVETLKQTLRKRNK--PYAVPDVREIFK---PSTTAAHSKQ------- 204

  Fly   136 SLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQV 200
                |||                 |:..:...:..|:   :.|..........|       |:..
Zfish   205 ----DEA-----------------ESTERSGSKKQEV---EGLGNGVGLIAAGG-------GADT 238

  Fly   201 RCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASE 265
            ..||.|..:...:.|.|.        ....:|.|.|          :.|.|....|      .|:
Zfish   239 ETDINLEVSFSEQALVYK--------EELKLSKPQC----------QADDRLPDFK------VSQ 279

  Fly   266 NECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELA 330
            ::.|:                                     |.|..:|..|||:::.::.:|::
Zfish   280 DKTGQ-------------------------------------TKVGDLSAEDMKKVRRLVLIEMS 307

  Fly   331 TIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQ-QVTGTDSSLVPLFLEKLIGELLRRG 394
            .:||...|.:...|..|.:.:|.| ||||.::.|:.:|| ::.||.   |||.|:.||..:..:|
Zfish   308 ALFDTCGVEVKAHKALKVKVRESG-LFGVPLSVLLDQDQRRIPGTK---VPLILQHLISHIEEQG 368

  Fly   395 SREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLF--RTATVHELSSLLKRWLRELPQPLLT 457
            ...||:|||.|...:.:.:.:|||..||      :.||  .:...|:.:||||.::||||.||||
Zfish   369 LDTEGVLRIPGAATRVKAVCHELEHKFY------EGLFPWESLKQHDAASLLKLFIRELPYPLLT 427

  Fly   458 NELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATI 521
            .:....|.....||: ..|:.||::|..|||..||:||::|:.||..:|:.||.|||.::|||.:
Zfish   428 VQYFNAFISVLKLPTQKQQLQALNLLVLLLPEHNRDTLKALMEFFQRVIHHKDKNKMTLNNVAVV 492

  Fly   522 MAPSMFPPRYIHPSDNNSIAEQ--VRMAAQCCRLTNILILRGEKLFQVPNNLIVESQK-TMMGKK 583
            |||::|    :.....:.|:||  ..||.....:..:||.....|:.:|..::.:.:| .|..::
Zfish   493 MAPNIF----MCKGFRSKISEQQEFAMATGTANIVRLLIRYQNLLWTIPKFILNQVRKHNMENQR 553

  Fly   584 GWHRHRNSNEITAK 597
            ..:|.|...::..|
Zfish   554 KMNRDRAVKKLLKK 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	81/225 (36%)
arhgap18	XP_001343601.7	RhoGAP_ARHGAP18	332..545	CDD:239856	81/225 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6505
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		otm25056
orthoMCL	1	0.900	-	-		OOG6_108161
Panther	1	1.100	-	-	O	PTHR14963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5254
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.950