DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cta and Gna11

DIOPT Version :9

Sequence 1:	NP_001036421.1	Gene:	cta / 3355131	FlyBaseID:	FBgn0000384	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_112295.1	Gene:	Gna11 / 81662	RGDID:	619749	Length:	359	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	160/365 - (43%)
Similarity:	223/365 - (61%)	Gaps:	24/365 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 CCGNIITYLVRLRSTPEELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRII 155
            ||           .:.|..|.:..:.||:|.|.::|...||::||||||.||||||||:||||||
  Rat     9 CC-----------LSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRII 62

  Fly   156 HGVNFDYELLLEYQSVIYQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLDVPKFM 220
            ||..:..|....:..::|||:...||.::.|.:.|.|.:   ..||:..:|.|:  ..:||.|..
  Rat    63 HGAGYSEEDKRGFTKLVYQNIFTAMQAVVRAMDTLKIRY---KYEQNKANALLI--REVDVEKVT 122

  Fly   221 ----EYAPPISRLWQDRGIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATK 281
                :|...|..||.|.|::..::||||||:|||..|:|.::.|:||..|:||.:|:|..|..|.
  Rat   123 TFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTT 187

  Fly   282 GVYEFCVKVQNIPFVFVDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEES 346
            |:.|:...::||.|..|||||||::|:||..||: :||||:|||:.||:||||.|....||:|||
  Rat   188 GIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFE-NVTSIMFLVALSEYDQVLVESDNENRMEES 251

  Fly   347 KNIFDTIVNNATFKGISIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFM 411
            |.:|.||:....|:..|:||||||.||||.|:.:  :.:..|:|.|:|........:.|||:||:
  Rat   252 KALFRTIITYPWFQHSSVILFLNKKDLLEDKILH--SHLVDYFPEFDGPQRDAQAAREFILKMFV 314

  Fly   412 SVRRSSSISRIYHHFTTAIDTRNINVVFNSVKDTILQRNL 451
            .:...|. ..||.|||.|.||.||..||.:|||||||.||
  Rat   315 DLNPDSD-KIIYSHFTCATDTENIRFVFAAVKDTILQLNL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	156/344 (45%)
cta	NP_001036421.1	G-alpha	133..451	CDD:206639	147/321 (46%)
Gna11	NP_112295.1	G_alpha	19..357	CDD:214595	156/344 (45%)
		G-alpha	40..353	CDD:206639	147/321 (46%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830