DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cta and GNAT3

DIOPT Version :9

Sequence 1:	NP_001036421.1	Gene:	cta / 3355131	FlyBaseID:	FBgn0000384	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001095856.1	Gene:	GNAT3 / 346562	HGNCID:	22800	Length:	354	Species:	Homo sapiens

Alignment Length:	349	Identity:	134/349 - (38%)
Similarity:	206/349 - (59%)	Gaps:	12/349 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 EELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSV 171
            |..|...:|||::|.|:::.....|.|||||||||||||||.:|||:|||...:..:..:|:::|
Human     8 ESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQECMEFKAV 72

  Fly   172 IYQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLD----VPKFMEYAPPISRLWQD 232
            ||.|.::.:..::.|...|.|.:.:....:|......| .|:|:    .|:..|.   |.|||:|
Human    73 IYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAM-ANTLEDGGMTPQLAEV---IKRLWRD 133

  Fly   233 RGIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNIPFVF 297
            .||:..|||..|:|::||.:|:|:::.|:....|||..:|:||.|..|.|:.|.....:::.|..
Human   134 PGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRM 198

  Fly   298 VDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNATFKGI 362
            .||||||::|:||..||: .||.|||..:.|.:|.||.||.:.||:.||.::|::|.|:..|...
Human   199 FDVGGQRSERKKWIHCFE-GVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFSTT 262

  Fly   363 SIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIYHHFT 427
            ||:|||||.|:.::||......|  .:|.:.| |::..|..|:|...|:.:........||.|.|
Human   263 SIVLFLNKKDIFQEKVTKVHLSI--CFPEYTG-PNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMT 324

  Fly   428 TAIDTRNINVVFNSVKDTILQRNL 451
            .|.||:|:..||::|.|.|::.||
Human   325 CATDTQNVKFVFDAVTDIIIKENL 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	132/344 (38%)
cta	NP_001036421.1	G-alpha	133..451	CDD:206639	124/321 (39%)
GNAT3	NP_001095856.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		7/18 (39%)
		G-alpha	34..348	CDD:206639	124/321 (39%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760