DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cta and gna13b

DIOPT Version :9

Sequence 1:	NP_001036421.1	Gene:	cta / 3355131	FlyBaseID:	FBgn0000384	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001013281.2	Gene:	gna13b / 336333	ZFINID:	ZDB-GENE-030131-8277	Length:	377	Species:	Danio rerio

Alignment Length:	386	Identity:	202/386 - (52%)
Similarity:	265/386 - (68%)	Gaps:	22/386 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LQTSRF--ACFRCCGNIITYLVRLRSTPEELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGES 143
            ||:..|  .||..|     :|     ...:.||..||||||:.:.|||...:|.||:||||||||
Zfish     5 LQSGSFLSLCFPNC-----FL-----DSSDAEQLRKSKEIDREIFKEKTFVKRLVKILLLGAGES 59

  Fly   144 GKSTFLKQMRIIHGVNFDYELLLEYQSVIYQNVIRGMQVLLDAREKLNIAWGSDGREQD-----A 203
            ||||||||||||||.:||.....|::..||.||::|::||:||||||:|.||:...:..     |
Zfish    60 GKSTFLKQMRIIHGDDFDKGDKEEFRGTIYSNVMKGVRVLVDAREKLHIPWGNPSNQTHADIMMA 124

  Fly   204 YDAK--LMECNSLDVPKFMEYAPPISRLWQDRGIRRAFERRREFQISDSVSYFLDEIQRLATPDY 266
            :|.:  ::....|:...|.:|.|.|..||.|.||:.|::||||||:.:||.||||.:.:|..|||
Zfish   125 FDTRSTMVSQGMLETKLFPQYLPSIRALWADIGIQHAYDRRREFQLGESVKYFLDNLDKLGAPDY 189

  Fly   267 VPTHKDILHCRKATKGVYEFCVKVQNIPFVFVDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFD 331
            :||.:|||..||.|||::|:..:::|:||..|||||||::|::|..||: |||||:|||||||:|
Zfish   190 LPTQQDILLARKPTKGIHEYDFEIKNVPFKMVDVGGQRSERRRWFECFE-SVTSILFLVSSSEYD 253

  Fly   332 QVLAEDRKTNRLEESKNIFDTIVNNATFKGISIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNP 396
            |||.|||:||||.||.|||:|||||..|..:|||||||||||||:||  ....|:.|:|.|..:|
Zfish   254 QVLMEDRQTNRLMESLNIFETIVNNRVFNNVSIILFLNKTDLLEEKV--KSVSIQDYFPEFTDDP 316

  Fly   397 HSVLDVQNFILQMFMSVRRSSSISRIYHHFTTAIDTRNINVVFNSVKDTILQRNLNALMLQ 457
            ..:.||:||:::.|.:.||......:||||||||:|.||.:||..||||||..||..||||
Zfish   317 WCLGDVKNFLVECFRNKRRDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	189/349 (54%)
cta	NP_001036421.1	G-alpha	133..451	CDD:206639	177/324 (55%)
gna13b	NP_001013281.2	G_alpha	29..375	CDD:214595	189/348 (54%)
gna13b	NP_001013281.2	G-alpha	49..371	CDD:206639	177/324 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586259
Domainoid	1	1.000	373	1.000	Domainoid score	I842
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1970
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D299429at33208
OrthoFinder	1	1.000	-	-		FOG0003447
OrthoInspector	1	1.000	-	-		otm25591
orthoMCL	1	0.900	-	-		OOG6_106101
Panther	1	1.100	-	-	O	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4590
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800