DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cta and GNAZ

DIOPT Version :9

Sequence 1:	NP_001036421.1	Gene:	cta / 3355131	FlyBaseID:	FBgn0000384	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_002064.1	Gene:	GNAZ / 2781	HGNCID:	4395	Length:	355	Species:	Homo sapiens

Alignment Length:	358	Identity:	139/358 - (38%)
Similarity:	201/358 - (56%)	Gaps:	11/358 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 RSTPEELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLE 167
            |.:.||.|...:|:.||:.|..|....||::||||||...|||||.:|||:|||...|:.|...|
Human     4 RQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEACKE 68

  Fly   168 YQSVIYQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLDVPKFMEYAPPI----SR 228
            |:.:|..|.|..:..::.|...|.|.:.:..|   ||||..:...:.......|..|.:    .|
Human    69 YKPLIIYNAIDSLTRIIRALAALRIDFHNPDR---AYDAVQLFALTGPAESKGEITPELLGVMRR 130

  Fly   229 LWQDRGIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNI 293
            ||.|.|.:..|.|..|:.:.|:.:|:|::::|:|..||:||.:|||..|..|.|:.|.....:.:
Human   131 LWADPGAQACFSRSSEYHLEDNAAYYLNDLERIAAADYIPTVEDILRSRDMTTGIVENKFTFKEL 195

  Fly   294 PFVFVDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNAT 358
            .|..|||||||::|:||..||: .||:|||.|..|.:|..|.||.:|:|:.||..:||:|.||..
Human   196 TFKMVDVGGQRSERKKWIHCFE-GVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNW 259

  Fly   359 FKGISIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIY 423
            |...|:||||||.|||.:|:......|  .:|.:.|. ::..:...:|.:.|..:.|:.....||
Human   260 FINTSLILFLNKKDLLAEKIRRIPLTI--CFPEYKGQ-NTYEEAAVYIQRQFEDLNRNKETKEIY 321

  Fly   424 HHFTTAIDTRNINVVFNSVKDTILQRNLNALML 456
            .|||.|.||.||..||::|.|.|:|.||..:.|
Human   322 SHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	134/346 (39%)
cta	NP_001036421.1	G-alpha	133..451	CDD:206639	125/321 (39%)
GNAZ	NP_002064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		8/21 (38%)
		G-alpha	34..349	CDD:206639	125/321 (39%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		9/12 (75%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830