Protein Alignment cta and GNAI2

DIOPT Version :9

• Sequence 1: NP_001036421.1
• Gene: cta / 3355131
• FlyBaseID: FBgn0000384
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_002061.1
• Gene: GNAI2 / 2771
• HGNCID: 4385
• Length: 355
• Species: Homo sapiens
• Alignment Length: 342
• Identity: 138/342 - (40%)
• Similarity: 207/342 - (60%)
• Gaps: 11/342 - (3%)

  Fly   114 KSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSVIYQNVIR 178
            :||.|||.|.::.....|:|||||||||||||||.:|||:|||...:..|...:|::|:|.|.|:
Human    15 RSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQ 79

  Fly   179 GMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLD---VPKFMEYAPPISRLWQDRGIRRAFE 240
            .:..::.|...|.|.:....|..||.....:.|.:.:   :|.  :.:..|.|||.|.|::..|.
Human    80 SIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPD--DLSGVIRRLWADHGVQACFG 142

  Fly   241 RRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNIPFVFVDVGGQRT 305
            |.||:|::||.:|:|::::|:|..||:||.:|:|..|..|.|:.|.....:::.|...||||||:
Human   143 RSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRS 207

  Fly   306 QRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNATFKGISIILFLNK 370
            :|:||..||: .||:|||.|:.|.:|.|||||.:.||:.||..:||:|.||..|...||||||||
Human   208 ERKKWIHCFE-GVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNK 271

  Fly   371 TDLLEQKVCNPETDIRWYYPHFNG-NPHSVLDVQNFILQMFMSVRRSSSISRIYHHFTTAIDTRN 434
            .||.|:|:.:....|  .:|.:.| |.:.  :..::|...|..:.:......||.|||.|.||:|
Human   272 KDLFEEKITHSPLTI--CFPEYTGANKYD--EAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKN 332

  Fly   435 INVVFNSVKDTILQRNL 451
            :..||::|.|.|::.||
Human   333 VQFVFDAVTDVIIKNNL 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	138/342 (40%)
		G-alpha	133..451	CDD:206639	129/321 (40%)
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	129/321 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		3/7 (43%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		5/8 (63%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830