Protein Alignment cta and GNA12

DIOPT Version :10

• Sequence 1: NP_001036421.1
• Gene: cta / 3355131
• FlyBaseID: FBgn0000384
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_031379.2
• Gene: GNA12 / 2768
• HGNCID: 4380
• Length: 381
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 191/354 - (53%)
• Similarity: 246/354 - (69%)
• Gaps: 9/354 - (2%)

  Fly   108 ELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSVI 172
            |.|.|.:|::||..|.:|:...||.||:||||||||||||||||||||||..||.:.|||::..|
Human    33 EREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTI 97

  Fly   173 YQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLDVP----KFMEYAPPISRLWQDR 233
            :.|:::|.:||:|||:||.|.|.....|:........| |...:|    .|..|.|.:|.||:|.
Human    98 FDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFE-NKAGLPVEPATFQLYVPALSALWRDS 161

  Fly   234 GIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNIPFVFV 298
            |||.||.||.|||:.:||.||||.:.|:...:|.|:.:|||..||||||:.|....::.|||..|
Human   162 GIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMV 226

  Fly   299 DVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNATFKGIS 363
            ||||||:|||||.:||| .:|||:|:|||||:||||.|||:||||.||.|||:|||||..|..:|
Human   227 DVGGQRSQRQKWFQCFD-GITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVS 290

  Fly   364 IILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIYHHFTT 428
            |||||||.|||.:||  ....|:.::|.|.|:||.:.|||.:::|.|...||:.| ..::|||||
Human   291 IILFLNKMDLLVEKV--KTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRS-KPLFHHFTT 352

  Fly   429 AIDTRNINVVFNSVKDTILQRNLNALMLQ 457
            ||||.|:..||::|||||||.||..:|||
Human   353 AIDTENVRFVFHAVKDTILQENLKDIMLQ 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	186/346 (54%)
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	184/341 (54%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	59..72		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	200..208		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	223..232		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	292..299		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	351..356		4/4 (100%)