DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cta and Gnat1

DIOPT Version :9

Sequence 1:	NP_001036421.1	Gene:	cta / 3355131	FlyBaseID:	FBgn0000384	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_032166.1	Gene:	Gnat1 / 14685	MGIID:	95778	Length:	350	Species:	Mus musculus

Alignment Length:	346	Identity:	139/346 - (40%)
Similarity:	216/346 - (62%)	Gaps:	13/346 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSVIYQ 174
            |::: |:|::|.|:::.....|.|||||||||||||||.:|||:|||...:..|..||:.::||.
Mouse     8 EEKH-SRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYG 71

  Fly   175 NVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLME-CNSLD---VPKFMEYAPPISRLWQDRGI 235
            |.::.:..::.|...|||.:|...|:.||  .|||. .::::   :||  |.:..|.|||:|.||
Mouse    72 NTLQSILAIVRAMTTLNIQYGDSARQDDA--RKLMHMADTIEEGTMPK--EMSDIIQRLWKDSGI 132

  Fly   236 RRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNIPFVFVDV 300
            :..|:|..|:|::||..|:|.:::||.||.||||.:|:|..|..|.|:.|.....:::.|...||
Mouse   133 QACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDV 197

  Fly   301 GGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNATFKGISII 365
            ||||::|:||..||: .||.|||:.:.|.:|.||.||.:.||:.||.::|::|.|:..|...||:
Mouse   198 GGQRSERKKWIHCFE-GVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIV 261

  Fly   366 LFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIYHHFTTAI 430
            |||||.|:..:|:......|  .:|.::| |::..|..|:|...|:.:.....:..||.|.|.|.
Mouse   262 LFLNKKDVFSEKIKKAHLSI--CFPDYDG-PNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCAT 323

  Fly   431 DTRNINVVFNSVKDTILQRNL 451
            ||:|:..||::|.|.|::.||
Mouse   324 DTQNVKFVFDAVTDIIIKENL 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	138/344 (40%)
cta	NP_001036421.1	G-alpha	133..451	CDD:206639	131/321 (41%)
Gnat1	NP_032166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/13 (38%)
		G-alpha	30..344	CDD:206639	131/321 (41%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	31..44		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	169..177		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	192..201		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	261..268		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	320..325		2/4 (50%)
		Interaction with RHO. /evidence=ECO:0000250\|UniProtKB:P04695	340..350		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830