DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lt and VPS41

DIOPT Version :9

Sequence 1:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_172297.2	Gene:	VPS41 / 837340	AraportID:	AT1G08190	Length:	980	Species:	Arabidopsis thaliana

Alignment Length:	927	Identity:	281/927 - (30%)
Similarity:	436/927 - (47%)	Gaps:	135/927 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNLSASER 82
            :|.:.||:.||.|:..::..:|:.|..:|.||..:.:..||..|.|.|.|..||.|      .|.
plant    36 DEAEEEPRLKYQRMGGNVPALLSNDAASCIAVAARMIALGTHDGTVRILDLLGNQV------KEF 94

  Fly    83 HTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPD-SKAHIKRF 146
            ..|...||:|:.|.:|||:.:|||||.|.|..||:.|......:.:.:|.:||:|| :|...|||
plant    95 RAHTAPVNDINFDTEGEYIGSCSDDGSVVINSLFTDDEKMKFDYHRPMKAISLDPDYTKKQSKRF 159

  Fly   147 VVGDDKLILYERNLLKKL---KPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCSLGLI 208
            |.|.....||..:  ||.   |...|.|.||.:.|:.|.|:.||||:.:||:|||..:...:..|
plant   160 VAGGLAGHLYMNS--KKWFGNKDQVLHSGEGPIHSVKWRGSLIAWANDVGVKVYDTAKDQRVTFI 222

  Fly   209 KWEVP-PQERLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNL------PVYIVDP 266
              |.| ...|.|....||.|.:...|:|||..::::..|:   |.:..||..      .:..||.
plant   223 --EKPRGSPRPEALLPHLVWQDDTLLVIGWGTSVKIASIK---SDQQQTGTFRQIQMSSLTQVDI 282

  Fly   267 ISTFQTTFYVCGLAPLSAKQLVVLGF-------RKEKSSCF------KALRPVLCVIEYKMNNSE 318
            :::|||::|:.|:||. ...||:|.:       .||.||..      .|.||.:.::.:   |::
plant   283 VASFQTSYYISGIAPF-GDSLVILAYIPIEGDGEKEFSSTTTLSRQGNAQRPEIRIVSW---NND 343

  Fly   319 EICTDSLTLRGFEEYTVNDYSL-----------GG---IIEENRFYIVAPKDIVVASLIETDDRI 369
            |:..|:|.:.|||.|...||||           ||   ..:|..:|||:|||:|:|...:.:|.|
plant   344 ELTMDALPVHGFEHYKAKDYSLAHAPFPGSSYAGGQWAAGDEPLYYIVSPKDVVIAKPRDAEDHI 408

  Fly   370 EWLIKHSKFEEAMELISANGGNVPVL-SVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEV 433
            .||::|...|:|:..:.|:.|...:: .|...|::||:..:||.:||.||.::|......||..|
plant   409 NWLLQHGFHEKALAAVEASEGRTELIDKVGAGYLDHLIVERKYAEAASLCPKLLRGSASAWERWV 473

  Fly   434 FKFVKCQQLRSVSAYLPTSDECKLDPHVYEMVLY------EFLKFDVCGFLNLIKEWPSHLYDGL 492
            |.|.:.:||..:..|:|| |..:|...|||:.|.      .:.|    ..|:.:|.||..:|..|
plant   474 FHFAQLRQLPVLVPYMPT-DNPRLKDTVYEVALVALATNPSYHK----ELLSAVKSWPRSVYSAL 533

  Fly   493 AVINAIHDNFR-KHYANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLI 556
            .||:||..... ....:.|.|:||.||...|.::.|..:|..|...:||..|.:|.|::.|...:
plant   534 TVISAIEPQLNTSSMTDALKEALAELYVIDGQYQKAFSLYADLLKPEVFDFIEKYSLHEAIRGKV 598

  Fly   557 IPLIQLDRDCAFEILLDKKKI--KTEIVVHQLE--------------HNQEYLYWYLDSL--LKK 603
            :.|:.||...|..:.:..:.:  .:|:|...|:              .::.|||.||.:|  :..
plant   599 VQLMLLDCKRATVLFIQNRDLIPPSEVVPQLLKAGKNPQVLKAGKKCDSRYYLYLYLHALFEVSH 663

  Fly   604 DPSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVICKQENFYPEIVYLLGCMGGVEASEA 668
            |....|....:.|||.:|...|||||:.|:.|.:::|..:|.:::|..|.|::||.||  .|.:|
plant   664 DTGKDFHDMQVELYAEYDTKMLLPFLRSSQHYKLEKAYELCVKKDFLREQVFVLGRMG--NAKQA 726

  Fly   669 LNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEIVTKVLDGIVDYFSPAVVVGKIKMGQ 733
            |.:||:::.|||.|:||.....|.|||..||.:....||:|..:|:..|....|..:|..:..|.
plant   727 LAVIINKLGDIEEAVEFVSMQHDDDLWEELIKQCLNKPEMVGLLLEHTVGNLDPLYIVNMVPNGL 791

  Fly   734 NIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSEIVTTQRRGQQVSYEQ---------- 788
            .||.||..|:|::..|..:..:......|...|...:..:.....|||..:|:|.
plant   792 EIPRLRDRLVKIVTDYRTETSLRHGCNDILKTDIVNLLVKCFNEARRGVCLSHEDDDSRAKREDN 856

  Fly   789 ------------------------------LCSLCHRPVLMAGTHLYCIIRLECGHVYHKPCIQG 823
                                          .|.:|..||.:.|.   .::...|.|.||:.|:..
plant   857 NRSSFSQRMVVDKSLSIKMTEVKSKTRGDTRCCMCFDPVSIRGD---TVVVFFCCHAYHETCLMD 918

  Fly   824 ELLKNCNECNLWKLTVG 840
            ....|.|.    |.|.|
plant   919 AAFSNNNH----KTTKG 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	14/47 (30%)
		WD40	<42..204	CDD:295369	64/165 (39%)
		WD40 repeat	90..123	CDD:293791	16/32 (50%)
		WD40 repeat	130..168	CDD:293791	16/41 (39%)
		CLH	570..707	CDD:128594	48/154 (31%)
		Clathrin	580..708	CDD:279031	49/143 (34%)
VPS41	NP_172297.2	WD40	62..>217	CDD:295369	63/162 (39%)
		WD40 repeat	63..96	CDD:293791	13/38 (34%)
		WD40	<70..256	CDD:225201	72/195 (37%)
		WD40 repeat	102..138	CDD:293791	16/35 (46%)
		WD40 repeat	143..186	CDD:293791	17/44 (39%)
		WD40 repeat	191..222	CDD:293791	12/30 (40%)
		WD40 repeat	229..270	CDD:293791	13/43 (30%)
		CLH	613..765	CDD:128594	48/153 (31%)
		Clathrin	617..765	CDD:279031	48/149 (32%)
		zf-RING_2	888..925	CDD:290367	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	280	1.000	Domainoid score	I401
eggNOG	1	0.900	-	-		E1_KOG2066
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69165
Inparanoid	1	1.050	384	1.000	Inparanoid score	I518
OMA	1	1.010	-	-		QHG54432
OrthoDB	1	1.010	-	-		D722805at2759
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto3580
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3779
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840