DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lt and vps41

DIOPT Version :9

Sequence 1:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_691671.2	Gene:	vps41 / 563215	ZFINID:	ZDB-GENE-030131-6671	Length:	854	Species:	Danio rerio

Alignment Length:	849	Identity:	325/849 - (38%)
Similarity:	495/849 - (58%)	Gaps:	56/849 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DSINEEDV--EPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNL 77
            |...|||.  |||.||.||.|.:..:|..|..:|..||.|||..||..|:|.:.|.||| |....
Zfish    17 DESEEEDTEEEPKLKYERLTNGVTEILQKDAASCMTVHDKFLALGTHFGKVFLLDIQGN-VTQKF 80

  Fly    78 SASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPD-SKA 141
            ..|     .|.:|.|.:|..|::|..||:||||.:.||::.:..|. :|...||||:|.|. ||:
Zfish    81 EIS-----SVKINQISLDESGDHVGICSEDGKVQVFGLYTREGFHE-NFDCPIKVVALHPQFSKS 139

  Fly   142 HIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCSLG 206
            :.|:||.|.:||:|||||.|.:.|...|...||::.|:.|.||.||||:::||::||:..:
Zfish   140 NNKQFVTGGNKLLLYERNWLNRWKTSVLHEGEGNITSVKWRGNLIAWANNVGVKIYDIGSK---- 200

  Fly   207 LIKWEVPPQERLEN------------FRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNL 259
                     :|:.|            :.|.|.|.:..||:|||..::::|.:::|:..|..  :|
Zfish   201 ---------QRITNVLRDNTSLRPDMYPCSLCWKDNTTLIIGWGCSVKICAVKERDPTEMR--DL 254

  Fly   260 PVYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSSCFK---ALRPVLCVIEYKMNNSEEIC 321
            |...|:.:|.|:|.|::.||||| |.|||.|.:.||.|...:   ..||.|.:|:......|||.
Zfish   255 PSRYVEIVSAFETEFFISGLAPL-ADQLVTLYYVKENSDHMEEEFRTRPRLDIIQPLPEGCEEIS 318

  Fly   322 TDSLTLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELIS 386
            :|:||:|.|:|....||.|.....|:.|||::|||||||...:.||.|:||::..|:|||:....
Zfish   319 SDALTVRNFQENQCRDYRLEHSEGESLFYIISPKDIVVAKERDQDDHIDWLLEKKKYEEALMAAE 383

  Fly   387 ANGGNVPVLSVAKL---YINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAY 448
            .:..|:....|.|:   |||||:....||.||:.|.::||.:..|||.||::|....||:::|.|
Zfish   384 ISFKNIKRHDVQKIGMAYINHLVEKGDYDTAARKCQKVLGKNMDLWENEVYRFKTIGQLKAISQY 448

  Fly   449 LPTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLE 512
            ||..| .:|.|.:|||:|::|||.|..||..||:|||..||:.:|::.|::::.:|...|. ||.
Zfish   449 LPRGD-LRLRPAIYEMILHDFLKTDYEGFATLIREWPGELYNNMAIVQAVNEHLKKDPTNSILLT 512

  Fly   513 SLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-K 576
            :||.||:|...::.||.:||:|::|||:|||.::.|:..|...|:.|:..|::.|.::|||.: |
Zfish   513 TLAELYTYDQRYDRALEIYLRLRHKDVYQLIHKHNLFSSIKDKIVLLMDFDKEKAVDMLLDNEDK 577

  Fly   577 IKTEIVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQE 639
            |..:.||.:|:...|.|:.||..|.|:|  ....:.::.|||||.|||..|||||:.|....:::
Zfish   578 ISMDKVVEELKDRPELLHVYLHKLFKRDHHKGQKYHERQISLYAEFDRPNLLPFLRESMHCPLEK 642

  Fly   640 ALVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSK 704
            ||.||:|.:|..|.|:||..||  ....||.:|:..:.:::.||||.||.||.:||..||:....
Zfish   643 ALEICQQRHFVEETVFLLSRMG--NCRRALQMIMEELANVDKAIEFAKEQDDRELWEDLISYSID 705

  Fly   705 HPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFE 769
            .|..:|.:|:.|..:..|.:::.:||.|..|||||.||:|:|..||||..:....::|.:.|...
Zfish   706 KPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILHDYNLQILLREGCKKILVADSLS 770

  Fly   770 IHSEIVTTQRRGQQVSYEQLCSLCHRPVLMAGT-HLYCIIRLECGHVYHKPCI--QGEL--LKNC 829
            :...:..||::|.:|..|.:|..||.|:|.:.| ..:.::...|.|::||.|:  .|.:  ::.|
Zfish   771 LLQRMHRTQKKGVRVDEENICESCHTPILPSDTAQAFGVVVFHCRHMFHKECLPSPGSIPGIQYC 835

  Fly   830 NECN 833
            |.|:
Zfish   836 NICS 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	18/47 (38%)
		WD40	<42..204	CDD:295369	69/162 (43%)
		WD40 repeat	90..123	CDD:293791	13/32 (41%)
		WD40 repeat	130..168	CDD:293791	21/38 (55%)
		CLH	570..707	CDD:128594	56/139 (40%)
		Clathrin	580..708	CDD:279031	52/129 (40%)
vps41	XP_691671.2	WD40	<44..215	CDD:225201	71/190 (37%)
		WD40 repeat	82..131	CDD:293791	20/54 (37%)
		WD40 repeat	137..169	CDD:293791	16/31 (52%)
		WD40 repeat	174..210	CDD:293791	14/48 (29%)
		TPR	328..589	CDD:223533	107/261 (41%)
		CLH	571..708	CDD:128594	56/138 (41%)
		Clathrin	575..710	CDD:279031	54/136 (40%)
		Vps39_2	713..814	CDD:287353	32/100 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596143
Domainoid	1	1.000	396	1.000	Domainoid score	I722
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69165
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1045
OMA	1	1.010	-	-		QHG54432
OrthoDB	1	1.010	-	-		D103854at33208
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto40530
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3779
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910