DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lt and Vps8

DIOPT Version :9

Sequence 1:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_648048.1	Gene:	Vps8 / 38735	FlyBaseID:	FBgn0035704	Length:	1229	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	191/983 - (19%)
Similarity:	338/983 - (34%)	Gaps:	354/983 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LNADVITCSAVHLKFLIFGTFRGRVCIFD--------HQ---GNSVYSNLSASERHTHQVA---- 88
            :||...:..|| ..|:..||..|.:..||        ||   |....::|:.:...|..:|
  Fly   118 VNAGAASSCAV-AAFIAIGTSHGHILNFDVTQTLRWAHQDKHGQGAVASLAFNADSTRLLAGFSR 181

  Fly    89 --VNNIDVDHKGEY------------------------VATCSDDG----------KVNITG--- 114
              |..:|. |.|:.                        :|.|:|.|          |:.|.|
  Fly   182 GLVAMLDT-HTGDVLRELFDVITPNTGVLHVKWTSRSSLALCADAGGSVWSLSFTRKLGIRGCQS 245

  Fly   115 --LFSSDNNHSLSFGKFIKVVSLEP---DSKAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEG 174
              |||         |...:|.::||   ||:        |..:|..|             |.|..
  Fly   246 RCLFS---------GARGEVCAVEPLIMDSQ--------GRHELDQY-------------CIVAL 280

  Fly   175 SVLSICWHGNFIAWASHIGVRVYDLNERCSLGLIKWEV---PPQERLENFRC--HLRWSNKHTLL 234
            :.||                :.:.:..|..|.:||:.|   ||.       |  .|.|   |.:|
  Fly   281 ATLS----------------KYFIVTVRPRLRVIKYHVLQGPPD-------CLPLLAW---HLVL 319

  Fly   235 IGWVDTIR----VCVIRKRN-----SIEASTGNLPVYIVDPISTFQTTFYVCGLAPL------SA 284
            |...||.|    |.|:.:.|     .:..|.|.:.:..:..:....:......|.|.      :|
  Fly   320 IQAADTSRSVDPVIVVGRGNQLFFHQLFVSNGRITLLYLRHVQLQGSLLSAHWLGPKCVASLDTA 384

  Fly   285 KQLVVLGFRKEK---------------SSCFKAL------RPVLCVIEYKMNNSEEICTDSLTLR 328
            :.|.::..|..|               |:.||.|      .|...:.      ....|.:|:..|
  Fly   385 EILHLVDVRSSKELECMDMANAGLVYGSAQFKGLATGGNVSPAFALA------GSNACYNSVVSR 443

  Fly   329 GFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGGNVP 393
            |                 .:.|::..:.:.:..:....:||.:|:||.:::||.:|  |..|.:.
  Fly   444 G-----------------TQLYVLGARSLHIIGVRTWSERISFLVKHHRWQEACQL--ALDGYIA 489

  Fly   394 --------------VLSVAKLYINHLLALKKYDDAAKL-CLRMLGNDKVLWEE----------EV 433
                          ::.:.|.||.:.....:|...|.: ||..:|...:||.:          |:
  Fly   490 SVDRPRKRAQAKERIIMLFKEYIANSARAPEYCLGAIVNCLITVGELDLLWTQLWEKLHNSSTEL 554

  Fly   434 F-----KFVKCQQLRSVSAYLPTSDECKLD------PHVYEMVLYEFLKFD-VCGFLN-LIKEWP 485
            |     :.::.:.:.||:   |...:..:|      |...|.::   ||.| :|..|| ::|...
  Fly   555 FLQHISEHIEKETIHSVN---PVISQALVDYWLEHSPAKLEQLI---LKLDWMCLDLNQVLKAVK 613

  Fly   486 SH-LYDGLAVIN--AIHDNFRKHYANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYE 547
            .| |:.....:|  |::|     |...|.|.|.|:...:.|..:.|.:|:.
  Fly   614 KHRLFRAQIYLNTQALND-----YTAALTELLPLVTPDETDLGNCLLVYVS-------------- 659

  Fly   548 LYDVISKLIIPLIQLDRDCAFEILLDKKKIKTEIVVHQLEHN---------------QEYLYWYL 597
                             .|.........:|..|: |||::|:               .|..|.||
  Fly   660 -----------------SCLAGREYPSGEIPVEL-VHQVKHDVLRCLTSQHSKENAGDELPYPYL 706

  Fly   598 DSLLKKDP-------SNVFQKKLIS-LYAIFDRNKLLPFLKRSKDYDIQEALVICKQEN-FYPEI 653
            .:|||.|.       |..||::..| ...|..|.:::..|           |.|...|| .:.||
  Fly   707 RALLKFDTRETLNVISLAFQEREFSNELGISHRKRIINLL-----------LEIMSPENATWAEI 760

  Fly   654 VYLLGCMGGVEAS-----------EALNIIIHRIRDIEMAIEFCKEHDD-SDLWNALIN-----E 701
                ||:....|.           :.|..::..:...|:|.|..::|.: .:.|:.|::     |
  Fly   761 ----GCLLNFIAQQISMQCLPRDRQLLERVLSHLAQEEIANESSRQHSERENAWHELLSSNCLAE 821

  Fly   702 FSKHPE------------IVTKVLDGIVDYFSPAVVVGKIK-----------MGQNIPNLRQSLI 743
            .|...|            :|..:|:.:..|  ..::...|:           |.:::.:.::|:.
  Fly   822 ISSDEEQLRLAEKAKCYCVVEYLLEKLERY--DTILDSYIRNEARHETMFAYMERHVASPKRSIF 884

  Fly   744 KMLRHYNLQGEILSSAQQ----IQLNDYFEIHSEIVTTQRRGQQVSYEQLCSLCHRPVLMAGTHL 804
            :.|:. ||:..:..:|::    :.|: |.|..:|::...||.:.:.|..|..|..|...:..:.:
  Fly   885 RQLKR-NLRELLTINAKETTRLLSLH-YPEKINELLDNLRREENLLYLFLKCLNDRKSELEASQM 947

  Fly   805 YCIIRLEC 812
            ..::.|.|
  Fly   948 ELLLELYC 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	14/52 (27%)
		WD40	<42..204	CDD:295369	42/220 (19%)
		WD40 repeat	90..123	CDD:293791	13/71 (18%)
		WD40 repeat	130..168	CDD:293791	8/40 (20%)
		CLH	570..707	CDD:128594	39/177 (22%)
		Clathrin	580..708	CDD:279031	39/180 (22%)
Vps8	NP_648048.1	WD40 repeat	123..156	CDD:293791	9/33 (27%)
		WD40 repeat	164..199	CDD:293791	7/35 (20%)
		WD40 repeat	208..241	CDD:293791	5/32 (16%)
		Vps8	554..725	CDD:315485	43/213 (20%)
		Clathrin	905..>1008	CDD:306985	12/52 (23%)
		RING_Ubox	1146..1189	CDD:327409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100