DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lt and Vps41

DIOPT Version :9

Sequence 1:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_038951647.1	Gene:	Vps41 / 306991	RGDID:	1560511	Length:	853	Species:	Rattus norvegicus

Alignment Length:	845	Identity:	318/845 - (37%)
Similarity:	491/845 - (58%)	Gaps:	42/845 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSWADSINEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYS 75
            :|..:|..|.:.|||.||.||:|.:..:|..|..:|..||.|||..||..|:|.:.|.||| :..
  Rat    14 ESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGN-ITQ 77

  Fly    76 NLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPD-S 139
            ....|     .|.:|.|.:|..||::..||:|||:.:.||:|.:..|. :|...||:|::.|. .
  Rat    78 KFDVS-----PVKINQISLDESGEHMGVCSEDGKLQVFGLYSGEEFHE-TFDCPIKIVAVHPQFV 136

  Fly   140 KAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCS 204
            ::..|:||.|..||:|:||..:.:.|...|...||::.|:.|.|:.||||:::||:::|:..:..
  Rat   137 RSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDITSKQR 201

  Fly   205 LGLIKWEVPPQE---RLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLPVYIVDP 266
            :    ..||..:   |.:.:.|.|.|.:..||:|||..:|::|.:::|::.|..  :||...|:.
  Rat   202 I----TNVPRDDISLRPDMYPCSLCWKDAVTLIIGWGTSIKICSVKERHASEMR--DLPSRYVEI 260

  Fly   267 ISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSS------CFKALRPVLCVIEYKMNNSEEICTDSL 325
            :|.|:|.||:.||||| ..|||||.:.||.|.      |   .||.|.:|:......|||.:|:|
  Rat   261 VSQFETEFYISGLAPL-CDQLVVLSYVKEVSEKTEREYC---ARPRLDIIQPLPETCEEISSDAL 321

  Fly   326 TLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGG 390
            |:|||:|....||.|.....|:.||:|:|:|:|||...:.||.|:||::..|:|||:.....:..
  Rat   322 TVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISHR 386

  Fly   391 NV---PVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTS 452
            |:   .:|.:...|:|||:...:||.||:.|.::||.:..|||.||:||.:..||:::|.|||..
  Rat   387 NIKRHKILEIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRG 451

  Fly   453 DECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLESLAL 516
            |.. |.|.:|||:|:|||:.|..||..||:|||..||:...::.|:.|:.:|...|: ||::||.
  Rat   452 DPV-LKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAE 515

  Fly   517 LYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-KIKTE 580
            ||:|..::.:||.:||.|::|||||||.::.|:..|...|:.|:..|.:.|.::|||.: ||..:
  Rat   516 LYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIK 580

  Fly   581 IVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVI 643
            .||.:||...|..:.||..|.|:|  ....:.:|.|||||.:||..|||||:.|....:::||.|
  Rat   581 KVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEI 645

  Fly   644 CKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEI 708
            |:|.||..|.||||..||  .:..||.:|:..:.|::.||||.||.||.:||..||......|..
  Rat   646 CQQRNFVEETVYLLSRMG--NSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPF 708

  Fly   709 VTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSE 773
            :|.:|:.|..:..|.:::.:||.|..|||||.||:|:|:.||||..:....::|.:.|...:..:
  Rat   709 ITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKK 773

  Fly   774 IVTTQRRGQQVSYEQLCSLCHRPVLMA-GTHLYCIIRLECGHVYHKPCIQGELL----KNCNECN 833
            :..||.:|..|..|.:|..|..|:|.. ....:.::...|.|::||.|:....|    :.||.|:
  Rat   774 MHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSLNAPAQYCNICS 838

Fly 834 833
Rat 839 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/47 (36%)
		WD40	<42..204	CDD:295369	59/162 (36%)
		WD40 repeat	90..123	CDD:293791	13/32 (41%)
		WD40 repeat	130..168	CDD:293791	14/38 (37%)
		CLH	570..707	CDD:128594	59/139 (42%)
		Clathrin	580..708	CDD:279031	55/129 (43%)
Vps41	XP_038951647.1	WD40 repeat	136..168	CDD:293791	11/31 (35%)
		WD40 repeat	173..204	CDD:293791	10/34 (29%)
		CLH	570..707	CDD:128594	59/138 (43%)
		RING-H2_Vps41	786..840	CDD:319604	14/53 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353944
Domainoid	1	1.000	388	1.000	Domainoid score	I766
eggNOG	1	0.900	-	-		E1_KOG2066
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69165
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1224
OMA	1	1.010	-	-		QHG54432
OrthoDB	1	1.010	-	-		D103854at33208
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto96567
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3779
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810