DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lt and VPS41

DIOPT Version :9

Sequence 1:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_055211.2	Gene:	VPS41 / 27072	HGNCID:	12713	Length:	854	Species:	Homo sapiens

Alignment Length:	848	Identity:	321/848 - (37%)
Similarity:	492/848 - (58%)	Gaps:	42/848 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SCDSWADSINEE--DVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGN 71
            |.:...|...||  :.|||.||.||:|.:..:|..|..:|..||.|||..||..|:|.:.|.|||
Human    11 SLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGN 75

  Fly    72 SVYSNLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLE 136
             :......|     .|.:|.|.:|..||::..||:||||.:.||:|.:..|. :|...||::::.
Human    76 -ITQKFDVS-----PVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHE-TFDCPIKIIAVH 133

  Fly   137 PD-SKAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDL- 199
            |. .::..|:||.|..||:|:||:.:.:.|...|...||::.|:.|.|:.||||:::||:::|:
Human   134 PHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDII 198

  Fly   200 -NERCSLGLIKWEVPPQE---RLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLP 260
             .:|.:      .||..:   |.:.:.|.|.|.:..||:|||..:::||.:::|::.|..  :||
Human   199 SKQRIT------NVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMR--DLP 255

  Fly   261 VYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFRK---EKSSCFKALRPVLCVIEYKMNNSEEICT 322
            ...|:.:|.|:|.||:.||||| ..|||||.:.|   ||:......||.|.:|:......|||.:
Human   256 SRYVEIVSQFETEFYISGLAPL-CDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISS 319

  Fly   323 DSLTLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAM---EL 384
            |:||:|||:|....||.|.....|:.||||:|:|:|||...:.||.|:||::..|:|||:   |:
Human   320 DALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEI 384

  Fly   385 ISANGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYL 449
            ...|.....:|.:...|||||:....||.||:.|.::||.:..|||.||:||.:..||:::|.||
Human   385 SQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYL 449

  Fly   450 PTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLES 513
            |..|.. |.|.:|||:|:|||:.|..||..||:|||..||:...::.|:.|:.:|...|: ||::
Human   450 PRGDPV-LKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKT 513

  Fly   514 LALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-KI 577
            ||.||:|..::.:||.:||.|::|||||||.::.|:..|...|:.|:..|.:.|.::|||.: ||
Human   514 LAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKI 578

  Fly   578 KTEIVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEA 640
            ..:.||.:||...|..:.||..|.|:|  ....:.:|.|||||.:||..|||||:.|....:::|
Human   579 SIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKA 643

  Fly   641 LVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKH 705
            |.||:|.||..|.||||..||  .:..||.:|:..:.|::.||||.||.||.:||..||......
Human   644 LEICQQRNFVEETVYLLSRMG--NSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDK 706

  Fly   706 PEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEI 770
            |..:|.:|:.|..:..|.:::.:||.|..|||||.||:|:|:.||||..:....::|.:.|...:
Human   707 PPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSL 771

  Fly   771 HSEIVTTQRRGQQVSYEQLCSLCHRPVLMA-GTHLYCIIRLECGHVYHKPCI----QGELLKNCN 830
            ..::..||.:|..|..|.:|..|..|:|.: ....:.::...|.|::||.|:    .....:.||
Human   772 LKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCN 836

  Fly   831 ECN 833
            .|:
Human   837 ICS 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/47 (36%)
		WD40	<42..204	CDD:295369	60/164 (37%)
		WD40 repeat	90..123	CDD:293791	14/32 (44%)
		WD40 repeat	130..168	CDD:293791	13/38 (34%)
		CLH	570..707	CDD:128594	59/139 (42%)
		Clathrin	580..708	CDD:279031	55/129 (43%)
VPS41	NP_055211.2	Interaction with ARL8B. /evidence=ECO:0000269\|PubMed:25908847	1..540		211/545 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		8/21 (38%)
		WD40 repeat	138..169	CDD:293791	11/30 (37%)
		WD40 repeat	174..205	CDD:293791	11/36 (31%)
		CHCR	568..712		60/145 (41%)
		CLH	571..708	CDD:128594	59/138 (43%)
		RING-H2_Vps41	787..841	CDD:319604	13/53 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159882
Domainoid	1	1.000	387	1.000	Domainoid score	I799
eggNOG	1	0.900	-	-		E1_KOG2066
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69165
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1144
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54432
OrthoDB	1	1.010	-	-		D103854at33208
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto89443
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1654
SonicParanoid	1	1.000	-	-		X3779
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800