DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17715 and Tmem65

DIOPT Version :9

Sequence 1:	NP_001036410.1	Gene:	CG17715 / 3355129	FlyBaseID:	FBgn0041004	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	XP_006521567.1	Gene:	Tmem65 / 74868	MGIID:	1922118	Length:	261	Species:	Mus musculus

Alignment Length:	254	Identity:	91/254 - (35%)
Similarity:	128/254 - (50%)	Gaps:	43/254 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PRGRELLRTQLIIPPSSTSSPFTCRNYSKFSTHLSMERALELLCNLDDEERGNLRSALGRLDADK 86
            |.|..||.|.      ....|....|        :.:.|.:.:.:|...||..|...|.|.::
Mouse    42 PGGPRLLGTH------PKKEPMEALN--------TAQGARDFIYSLHSTERSCLLKELHRFES-- 90

  Fly    87 EKKLYESQLAFGSWRTRFGR----LSNKTELGQVIAGTFCAVPDDWLRKKLVETAASPTAGQLYS 147
                    :|... ..||.:    ::.:.|  :|.|   ...||.:  :||  .|..||.|||..
Mouse    91 --------IAIAQ-ACRFPKPEVVIAKRAE--EVSA---AETPDSF--EKL--EALPPTPGQLRY 137

  Fly   148 IFFVNAVPFIAFGFLDNFIMIMAGEYIEYYLGHFITLSTMAAAGLGNTISDILGITMATYVENGC 212
            :||.||:||:.||||||.|||:||..||..:|..:.:||||||.|||.:||:.|:.:|.|||...
Mouse   138 VFFHNAIPFVGFGFLDNAIMIVAGTQIELSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALA 202

  Fly   213 QILGLKQPNLTPAQFELKSSKRSSSYGRIVGITVGCLLGMCPLWFM-----DEKADKVN 266
            ..|||..|:|||.|.::..::.|:..|:.||:|:||:|||.||.|.     |||.:..|
Mouse   203 SRLGLSIPDLTPKQVDMWQTRVSTHLGKAVGVTIGCILGMFPLIFFGGSEEDEKLETTN 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17715	NP_001036410.1	DUF2453	151..258	CDD:287478	54/106 (51%)
Tmem65	XP_006521567.1	TMEM65	141..248	CDD:371101	54/106 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834919
Domainoid	1	1.000	113	1.000	Domainoid score	I6135
eggNOG	1	0.900	-	-		E1_KOG4619
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006142
OrthoInspector	1	1.000	-	-		oto93003
orthoMCL	1	0.900	-	-		OOG6_104678
Panther	1	1.100	-	-	LDO	PTHR21706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4172
SonicParanoid	1	1.000	-	-		X4432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730