DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and Slmap

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001297374.1	Gene:	Slmap / 83997	MGIID:	1933549	Length:	845	Species:	Mus musculus

Alignment Length:	773	Identity:	212/773 - (27%)
Similarity:	372/773 - (48%)	Gaps:	153/773 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 AAKIVLLCEPKSHKFETRSILLQPNQDCKVGRLIAKSKAGEGNAIFDCKVLSRNHAILWYT-PDG 271
            :|..:..|.|.||.|:.|.:.|  ::..|:||.:|:.:..:.||.|||||||||||::|:. ...
Mouse     3 SALAIFTCRPNSHPFQERHVYL--DEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTS 65

  Fly   272 KFWVKDTKSSNGTFINDNKLG-----SDPAELHYGDIVKFGVEVIENSRQEVHGCILARVALFLP 331
            ||:::|||||||||||..:|.     |.|.|:..|||::|||:|.||:|:..||||::.:.||||
Mouse    66 KFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLP 130

  Fly   332 NGQEA----------ISVEAEQMMLTVPNRISFDEVQRLSSFLQEAAQREKSLKAKLSSLQGVLD 386
            :|.||          :....:::....|:..| .|:.:||.:||||..||:.|:.||::||.:|.
Mouse   131 DGMEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQRLLA 194

  Fly   387 NTRKNSAMCWQSMITEDQLLHKINILEKKLQMMEKNIPENALRNEIVKLLEDKTTYQLTAKEALR 451
            .|::.|...||::|.||:||.::.::..:||...||..|::||.|::.|.|||.:|:.||||:||
Mouse   195 ITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHSYETTAKESLR 259

  Fly   452 KVYQERCDAMQMLSKMEMAYATSENECGIL-----RAQVLTLKQTLTDFNTRLEELQQ-----EY 506
            :|.||:.:.::.||::|.:.:.:|:||..|     |.|. .|::....:|..:.|::.     :.
Mouse   260 RVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQE-ELRELANKYNGAVNEIKDLSDKLKV 323

  Fly   507 MEFKKESVRQEQEAKEQESRSLEVLNGKLTTQELELKELRLQVSRIHRD---LSESDT------E 562
            .|.|:|.::|:.:|:::|      |..|:...|.:.:||:.::..:..|   .:|..|      |
Mouse   324 AEGKQEEIQQKGQAEKKE------LQTKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVRLE 382

  Fly   563 HLKERIVLKNLDT--INLDDY----------DH-------------------------------A 584
            ||:|: .||...:  |.:||:          :|                               .
Mouse   383 HLQEK-TLKECSSLGIQVDDFLPKINGSTEKEHLLSKSGGDCTFIHQFLECQKKLMVQGHLTKVV 446

  Fly   585 QDRALNERDDNESSDDDIL-SVSPAKNVLSETKK-------------RKLKLSNPDLE----EGN 631
            ::..|::.:..::.:.|:. ::||:|...|:...             .|:.|...||:    |..
Mouse   447 EESKLSKENQAKAKESDLSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGTQSETE 511

  Fly   632 YKSNVLRLLKNSDLGKGEEGSSVLKAIFNGDDEAFECK-VKEEEDMANDSVPTEFVSRNTSEIVD 695
            .|.::..|.|  :|.:.:|.:...|      .:.||.: :.|||..|..:...|...:.....|.
Mouse   512 AKQDIQHLRK--ELVEAQELARTSK------QKCFELQALLEEERKAYRNQVEESAKQIQVLQVQ 568

  Fly   696 HFKNHSSTTHTILEDSAATKLSAPNAESKEKLVDVEENLNIPNALPTEQAID------MLQE--- 751
            ..|.|....:  |::...|::|:    :::||:..::.:.:......|...:      .|||
Mouse   569 LQKLHMDMEN--LQEEKDTEISS----TRDKLLSAQDEILLLRQAAAEAVSERDTDFVSLQEELK 627

  Fly   752 ----ECDTYKKKTAHLTSEIHFLQGQIELLKKQLEKGVDHNFATNLQEEENSLPRETLELIDNRD 812
                |.:.::|..:...:||..||...:|..:|.| ......||.||.|...|.:|
Mouse   628 KVRAELEGWRKAASEYENEIRSLQSSFQLRCQQCE-DQQREEATRLQGELEKLKKE--------- 682

  Fly   813 STEGVWN---EDIATINNPNVENEEELIVYKELLENSELNNMQLRKEISELHLKHKHI 867
                 |:   .:..::...||....||...::.|.||:..:.:|..::|.|.:..|.:
Mouse   683 -----WDVLETECHSLKKENVLLSSELQRQEKELHNSQKQSFELTSDLSILQMTRKEL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	47/100 (47%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	51/106 (48%)
Slmap	NP_001297374.1	Necessary for targeting to centrosomes	1..163		72/175 (41%)
		FHA	14..108	CDD:238017	47/99 (47%)
		FHA	<46..109	CDD:224630	38/68 (56%)
		SMC_prok_B	<163..812	CDD:274008	139/597 (23%)
		DUF342	<297..367	CDD:302792	19/83 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..484		8/33 (24%)
		DUF342	<618..696	CDD:302792	11/45 (24%)
		TMPIT	680..>775	CDD:285135

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4243
eggNOG	1	0.900	-	-		E1_COG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003045
OrthoInspector	1	1.000	-	-		oto95314
orthoMCL	1	0.900	-	-		OOG6_106606
Panther	1	1.100	-	-	O	PTHR15715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R322
SonicParanoid	1	1.000	-	-		X5155
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.850