DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and SLMAP

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001364467.1	Gene:	SLMAP / 7871	HGNCID:	16643	Length:	852	Species:	Homo sapiens

Alignment Length:	726	Identity:	221/726 - (30%)
Similarity:	362/726 - (49%)	Gaps:	144/726 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 AAKIVLLCEPKSHKFETRSILLQPNQDCKVGRLIAKSKAGEGNAIFDCKVLSRNHAILWYT-PDG 271
            :|..:..|.|.||.|:.|.:.|  ::..|:||.:|:.:..:.||.|||||||||||::|:. ..|
Human     3 SALAIFTCRPNSHPFQERHVYL--DEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTG 65

  Fly   272 KFWVKDTKSSNGTFINDNKLG-----SDPAELHYGDIVKFGVEVIENSRQEVHGCILARVALFLP 331
            ||:::|||||||||||..:|.     |.|.|:..|||::|||:|.||:|:..||||::.:.||||
Human    66 KFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLP 130

  Fly   332 NGQEA----------ISVEAEQMMLTVPNRISFDEVQRLSSFLQEAAQREKSLKAKLSSLQGVLD 386
            :|.||          :....:::....|:..| .|:.:||.:||||..||:.|:.||::||.:|.
Human   131 DGMEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQRLLA 194

  Fly   387 NTRKNSAMCWQSMITEDQLLHKINILEKKLQMMEKNIPENALRNEIVKLLEDKTTYQLTAKEALR 451
            .|::.|...||::|.||:||.::.::..:||...||..|::||.|::.|.|||..|:.||||:||
Human   195 ITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLR 259

  Fly   452 KVYQERCDAMQMLSKMEMAYATSENECGIL-----RAQVLTLKQTLTDFNTRLEELQQ-----EY 506
            :|.||:.:.::.||::|.:.:.:|:||..|     |.|. .|::....:|..:.|::.     :.
Human   260 RVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQE-ELRELANKYNGAVNEIKDLSDKLKV 323

  Fly   507 MEFKKESVRQEQEAKEQESRSLEVLNGKLTTQELELKELRLQVSRIHRDLSESDTEHLKERIVLK 571
            .|.|:|.::|:.:|:::|      |..|:  .|:|.||..|| ::|  :..::|.:...||:...
Human   324 AEGKQEEIQQKGQAEKKE------LQHKI--DEMEEKEQELQ-AKI--EALQADNDFTNERLTAL 377

  Fly   572 NLDTINLDDYDHAQDRALNERDDNESSDDDILSVSPAKNVLSETKKRKLKLSNPD---------- 626
            .:      ..:|.|::.|.|........||.|   |..|..:| |:..|..|..|
Human   378 QV------RLEHLQEKTLKECSSLGIQVDDFL---PKINGSTE-KEHLLSKSGGDCTFIHQFIEC 432

  Fly   627 ----LEEGNY----------KSNVLRLLKNSD----LGKGEEGSSVLKAIFNGDDEAFECKVKEE 673
                :.||:.          |.|..| .|.||    |...:|.||         |:..:.::.|:
Human   433 QKKLIVEGHLTKAVEETKLSKENQTR-AKESDFSDTLSPSKEKSS---------DDTTDAQMDEQ 487

  Fly   674 ---EDMANDSVPTEFVSRNTSEI-----VDHFKNHSSTTHTILEDSAATKLSAPNAESKEKLVDV 730
               |.:|..|:..:.:....|||     :.|.:..      ::|   |.:|:   ..||:|..::
Human   488 DLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKE------LIE---AQELA---RTSKQKCFEL 540

  Fly   731 EENLNIPNALPTEQAIDMLQEECDTYKKKTAHLTSEIHFLQGQIELLKKQLEKGVDHNFATNLQE 795
            ::.:.:..||        |:||...|:.:....|.:|..||.|::.|         |....||:|
Human   541 QDTVFLLLAL--------LEEERKAYRNQVEESTKQIQVLQAQLQRL---------HIDTENLRE 588

  Fly   796 EENSLPRETL-ELIDNRD-------STEGVWNE---DIATINNPNVENEEELIVYKELLENSELN 849
            |::|....|. ||:..||       :...|.:|   |||::       :|||...:..||.....
Human   589 EKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASL-------QEELKKVRAELERWRKA 646

  Fly   850 NMQLRKEISEL 860
            ..:..|||:.|
Human   647 ASEYEKEITSL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	48/100 (48%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	52/106 (49%)
SLMAP	NP_001364467.1	FHA	14..108	CDD:238017	46/95 (48%)
		SMC_prok_B	<163..819	CDD:274008	154/563 (27%)
		CC1_SLMAP	163..225	CDD:409287	24/61 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I4278
eggNOG	1	0.900	-	-		E1_COG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3250
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003045
OrthoInspector	1	1.000	-	-		oto91733
orthoMCL	1	0.900	-	-		OOG6_106606
Panther	1	1.100	-	-	O	PTHR15715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R322
SonicParanoid	1	1.000	-	-		X5155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.850