DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and CCDC136

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_011514785.1	Gene:	CCDC136 / 64753	HGNCID:	22225	Length:	1231	Species:	Homo sapiens

Alignment Length:	1033	Identity:	180/1033 - (17%)
Similarity:	368/1033 - (35%)	Gaps:	280/1033 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DEDQTSSSLSPTPASGAVGSTALNR-TGTTDTATELP-------------QTTRYPSG--EEPAV 62
            :|::...........|:|||.::|: .|.:.|.|||.             :.||..:|  |:.::
Human    73 EEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSL 137

  Fly    63 KPEEAQYALNMETEKNLEQDNFF--HIMDIKEDMADSNNEASTKNQENNNMELCDSNTVCIDRRP 125
               |.|..|..|...:.:|...|  .|..::.::.....|.|....|..:           :.:.
Human   138 ---ELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKES-----------ELKE 188

  Fly   126 AEVSQHAMNMAMNSVLNANNTGVGVRVTTACSLFSPLGVLNNSA---------LQREVASECGTL 181
            .|...|.....:.|:..|.........:...||...|..:.|..         .:.|:||....:
Human   189 IEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEM 253

  Fly   182 QVSSVPPTSGVDLDIGLESAPTPCKGAAKIVLLCEPKSHKFETRSILLQPNQDCKVGRLIAKSKA 246
            ::.|..|:..:.|        :...|..:.:.....:.|........||.:.....|:|......
Human   254 EMKSSEPSGSLGL--------SDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESE 310

  Fly   247 GEGNAI---FDCKVLSRNHAILWYTPDGKFWVKDTKSSNGTFINDNKLGSDPAELHYGDIVKFGV 308
            ....|.   ...:.||...|             ::::|...|     |..||.       ::...
Human   311 RTQRATERWLQSQTLSMTSA-------------ESQTSEMDF-----LEPDPE-------MQLLR 350

  Fly   309 EVIENSRQEVHGCILARVALFLPNGQEAISVEAEQMMLTVPNRISFDEVQRLSSFLQEAAQRE-- 371
            :.:.::.:::||         :.|..:.:..|.|:  |....::|.:|.:||...| :.||.|
Human   351 QQLRDAEEQMHG---------MKNKCQELCCELEE--LQHHRQVSEEEQRRLQREL-KCAQNEVL 403

  Fly   372 -----------KSLKAKLSSLQGVLDNTR--KNSAMCWQ--------------SMITEDQ----- 404
                       :.||::|.:||...|.::  :|..:..|              |.:.|:|
Human   404 RFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKEL 468

  Fly   405 --------LLH------KINILEKKLQMMEKNIPENA----LRNEIVKLLE--DKTTYQLTAKEA 449
                    |.|      |..:||::.|:.|:.....|    ||:.:....|  :|.|......:.
Human   469 LCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQE 533

  Fly   450 LRKVYQERCDAMQM------------------LSKMEMAYATSE------NECGILRAQVLTLKQ 490
            ::::||...|.::.                  |.:::.::...|      |:|..|.:::..|::
Human   534 MKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQE 598

  Fly   491 TLTDFNTRLEELQQEYMEFKKESVR-QEQEAKEQE----------SRSLEVLNGKLTTQELELKE 544
            ........:.:||.|..|..::..| ||::.:.||          ...|.:.:.:|.|:..:|.|
Human   599 KYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCE 663

  Fly   545 LRLQVSRIHRDLSESDTEHLKERIVLKNLDTINLDDYD-HAQDRALNE---RDDNESSDDDILSV 605
            |:|    :::.:.|      :::.:::|.|.:..:..: |.:.|...|   ::..|:.||..|:.
Human   664 LQL----LYQGMQE------EQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAK 718

  Fly   606 SPAKNVLSETKKRKLKLSNPDLEEGNYKSNVLRLLKNSDLGKGEEGSSVLKAIFNGDDEAFECKV 670
            |...|...:.:.:......||.|.|   ..:..|:::..|   .|....|:.:::......|...
Human   719 SSKCNRNKQPRSQAQHAQRPDSELG---QEIQELIQSKLL---MEQMQALQVMYDAGQAKQELLQ 777

  Fly   671 KEE------------------EDMA--------------------NDSVPTEFVSRNTSE-IVD- 695
            :|:                  |:|.                    ...||:....|.|.: .||
Human   778 QEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDD 842

  Fly   696 ---HFKNHSST---THTILEDSAATKLSAPNAESKEKLVDVEENLNIPNALPTEQAIDMLQ---- 750
               ::|:::||   :.:.|: |..:..||..|..|........::....:..:..:.|..|
Human   843 NESYYKSYTSTQTSSKSFLK-SYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFV 906

  Fly   751 -----------EECDTYKKKTAHLTSEIHFLQGQIELLKKQLEKGVDHNFATNLQEEENSLPRET 804
                       |:.:.:::....:..::..:|...::.::      :|   :.|||:...|..:.
Human   907 SSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQE------EH---SQLQEQMEKLLAKQ 962

  Fly   805 LELIDNRDSTEGVWNEDIATINNP----NVENEEELIVYKELLENSELNNMQLRKEIS 858
            .:|.:..|:.|..:.|.:..:..|    |.:||     .|||  .::|..:||:.:.|
Human   963 KDLKEELDACEREFKECMECLEKPMAPQNDKNE-----IKEL--QTKLRELQLQYQAS 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	14/97 (14%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	15/103 (15%)
CCDC136	XP_011514785.1	RILP-like	<105..194	CDD:304877	18/102 (18%)
CCDC136	XP_011514785.1	SMC_prok_B	275..1044	CDD:274008	140/809 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157113
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940