DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slmap and Rnf8

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_067394.1	Gene:	Rnf8 / 58230	MGIID:	1929069	Length:	488	Species:	Mus musculus

Alignment Length:	494	Identity:	109/494 - (22%)
Similarity:	183/494 - (37%)	Gaps:	143/494 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LQPNQDCKVGR-------LIAKSKAGEGNAIFDCK-VLSRNHAILWYTPDGKFWVKDTKSSNGTF 285
            |:...:..:||       ||:|.          |. ::||:|.:|...|:|::.:.|.||.||.:
Mouse    32 LEAGTEVTIGRGLSVTYQLISKV----------CPLMISRSHCVLKQNPEGQWTIMDNKSLNGVW 86

  Fly   286 INDNKLGSDPAE---LHYGDIVKFGV------------EVIENSRQEVHGCILARVALFLPNGQE 335
            :|..:|.  |.:   :..||.::.||            ||||...:.:..|:..:      |.|.
Mouse    87 LNRERLA--PLQGYCIRKGDHIQLGVPLESRETAEYEYEVIEEDWESLAPCLAPK------NDQR 143

  Fly   336 AISVEAEQM--------MLTVPNRISFDEVQRLSSFLQEAAQREK-------------------- 372
            ....:..:.        :..:|...|.|....|::...:..:.||
Mouse   144 MEKHKGSRTKRKFSSPGLENLPAEGSSDLRCPLANVASKPIEPEKLHGKGDASSQSLGCLCPGLT 208

  Fly   373 SLKAK--------LSSLQGVLD-NTRKNSAMCWQSMITEDQLLHKI---NILEKKLQMMEKNIP- 424
            ||||.        .|:|..||: :..|....|..|.......|.|:   .:|:.|.||.||.|.
Mouse   209 SLKASERAAGPHACSALPKVLELSCPKKQKACRPSASQNSLELFKVTMSRMLKLKTQMQEKQIAV 273

  Fly   425 ------------------ENALRNEIVKLLEDKTTYQLTAKEALRKVYQERCDAMQMLSKMEMAY 471
                              |..|||...:|..::...|... |.|.|.:||....:|.|.|
Mouse   274 LNVKRQTRKGSSKKIVRMEKELRNLQSQLYAEQAQQQARV-EQLEKTFQEEAHYLQGLEK----- 332

  Fly   472 ATSENECGILRAQVLTLKQTLTDFNTRLEELQQEYMEFKK--ESVRQEQEAKEQESRSLEVLNGK 534
              .:.||. |:.|   |.|.|.:....:|||.....:|:|  ::..:|.|..::|...::....:
Mouse   333 --EQGECD-LKQQ---LVQALQEHQALMEELNCSKKDFEKIIQAKNKELEQTKEEKDKVQAQKEE 391

  Fly   535 LTTQELELKELRLQ-------------VSRIHRDLSESDTEHLKER----IVLKNLD--TINLDD 580
            :.:...:|.|..||             ::..|...|....|.:|.:    |..|:::  |.:|
Mouse   392 VLSHMNDLLENELQCIICSEYFIEAVTLNCAHSFCSFCINEWMKRKVECPICRKDIESRTNSL-- 454

  Fly   581 YDHAQDRALNERDDNESSDDDILSVSPAKNVLSETKKRK 619
               ..|..:::..||.|||     |...::||...::.|
Mouse   455 ---VLDNCISKMVDNLSSD-----VKERRSVLIRERRAK 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	26/104 (25%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	30/119 (25%)
Rnf8	NP_067394.1	FHA	17..110	CDD:238017	23/89 (26%)
		FHA	<38..109	CDD:224630	22/82 (27%)
		Required for interaction with PIWIL1. /evidence=ECO:0000255\|HAMAP-Rule:MF_03067, ECO:0000269\|PubMed:28552346	68..72		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..164		1/22 (5%)
		CENP-F_leu_zip	268..391	CDD:287450	32/134 (24%)
		Cytochrom_B562	<291..366	CDD:294917	25/86 (29%)
		RING	405..447	CDD:238093	7/41 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900