DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and slmapa

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_005168117.1	Gene:	slmapa / 572011	ZFINID:	ZDB-GENE-061013-184	Length:	847	Species:	Danio rerio

Alignment Length:	764	Identity:	217/764 - (28%)
Similarity:	354/764 - (46%)	Gaps:	209/764 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 AAKIVLLCEPKSHKFETRSILLQPNQDCKVGRLIAKSKAGEGNAIFDCKVLSRNHAILWYT-PDG 271
            :|..|..|.|.||.|:.|.:.|  ::..|:||.:|:.:..:.||.|||||||||||::|:. ..|
Zfish     3 SALAVFSCRPNSHPFQERHVYL--DEPVKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTG 65

  Fly   272 KFWVKDTKSSNGTFINDNKLG-----SDPAELHYGDIVKFGVEVIENSRQEVHGCILARVALFLP 331
            ||:::|||||||||||..:|.     |.|.|:..|||::|||:|.||:|:..||||::.:.||||
Zfish    66 KFYLQDTKSSNGTFINSQRLSRGSEESPPCEVLSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLP 130

  Fly   332 NGQEA----------ISVEAEQMMLTVPNRISFDEVQRLSSFLQEAAQREKSLKAKLSSLQGVLD 386
            :|.||          :.:..:::....|:..| .|:.:||.:||||..||:.|:.||::||.:|.
Zfish   131 DGMEARRRSDVVPAPLPLAIDKVSANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQRLLA 194

  Fly   387 NTRKNSAMCWQSMITEDQLLHKINILEKKLQMMEKNIPENALRNEIVKLLEDKTTYQLTAKEALR 451
            :|::.|...||::|.||:||.::.::..:||...||..|:.:|.|:|.|.|||..|:.||||:||
Zfish   195 STQEASESSWQALIDEDRLLSRLEVMGNQLQAYSKNQTEDGIRKELVALTEDKHNYETTAKESLR 259

  Fly   452 KVYQERCDAMQMLSKMEMAYATSENECGILRA---------------------QVLTLKQTLTDF 495
            :|.||:.:.::.||::|.:.:.:|:||..||.                     ::..|.:.:...
Zfish   260 RVLQEKIEVVRKLSEVERSLSNTEDECTHLREMNERTQEELRELANKYNGAVNEIKDLTEKIKLA 324

  Fly   496 NTRLEELQQEYMEFKKE-SVR-QEQEAKEQESRS-LEVL-------NGKLTTQELELKELRLQVS 550
            ..:.|||.|:.:..||| .:| :|.|.|||..:: :|.|       |.:||..::.|::|:
Zfish   325 EDKHEELTQKGLNEKKELQMRIEEMEEKEQALQARIEALQADNDFTNERLTALQVRLEQLQ---- 385

  Fly   551 RIHRDLSESDT-EH-----------------------LKERI-----VLKNLDTI---NLDDYDH 583
              .:.:.|::: :|                       |||.:     .|.|.|.:   :|.:...
Zfish   386 --EKSIKENNSFDHFLLKSGGDCTLIQQYIECQSVRQLKEAVDSSINKLSNFDEVIDAHLQNNQT 448

  Fly   584 AQDRAL--------NERDDNESSDDDILSVSPAKNVLSETKKRKLKLSNPDLEEGNYKSNVLRLL 640
            ..|.:|        |:.|..|....|.||.|..|             |:.|..:|.        :
Zfish   449 TVDNSLPSPDRLKENQIDAKECDMSDTLSPSKEK-------------SSDDTSDGQ--------M 492

  Fly   641 KNSDLGKGEEGSSVLKAIFNGDDEAFECKVKEEEDMANDSVPTEFVSRNTSEIVDHFKNHSSTTH 705
            :..:|.:.:...|:||.:    |.:.|         |.|          |.:::.|.       |
Zfish   493 EEQELNEPQNRVSLLKEM----DRSLE---------AGD----------TEQVIPHI-------H 527

  Fly   706 TILEDSAATKLSAPNAESKEKLVDVEENLNIPNALPTEQAIDMLQEECDTYKKKTAHLTSEIHFL 770
            ..|::  |.:|:   ...|:|.::::.               ||:||..|.:::|.....:|.||
Zfish   528 RELQE--AQELA---NTGKQKCLELQA---------------MLEEERKTNRQQTEESAKQIRFL 572

  Fly   771 QGQI-------ELLKKQLEKGVDHNFATNLQEEENSLPRETLELIDNRDSTEGVWNEDIATINNP 828
            |.|:       |.|::|.|     |..|..:||..|...|.|.|   |.:.|..
Zfish   573 QTQLAKLQTDMEALREQRE-----NTITTTREELYSAQEEILVL---RHAMEAA----------- 618

  Fly   829 NVENEEEL--------IVYKELLE--------NSELNNMQLRKEISELH 861
            ..|.|.|:        ||..||.:        ..|::|:|...::...|
Zfish   619 TAEREREITALQGDLSIVTAELDKWRQTAAKYEVEISNLQASFQLQSQH 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	48/100 (48%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	52/106 (49%)
slmapa	XP_005168117.1	FHA	14..108	CDD:238017	46/95 (48%)
		FHA	<46..109	CDD:224630	36/62 (58%)
		SMC_prok_B	<163..>814	CDD:274008	149/601 (25%)
		DUF5098	287..>496	CDD:293628	45/235 (19%)
		DUF342	<297..367	CDD:302792	16/69 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4814
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3394
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003045
OrthoInspector	1	1.000	-	-		oto39680
orthoMCL	1	0.900	-	-		OOG6_106606
Panther	1	1.100	-	-	O	PTHR15715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R322
SonicParanoid	1	1.000	-	-		X5155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.990