DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and Ccdc136

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_006236301.3	Gene:	Ccdc136 / 362331	RGDID:	1564459	Length:	1187	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	182/1016 - (17%)
Similarity:	353/1016 - (34%)	Gaps:	285/1016 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ELPQTTRYPSGEEPAVKPEEAQYALNMETEKNLEQDNFFHIMDIKEDM-----------ADSNNE 100
            |:.|.......|...::...|..|...|::....||:...:.:..:||           |....|
  Rat   188 EIEQELHLAQAEIHNLRQAAADSATEHESDIASLQDDLCRLQNELDDMERIRGDYEMEIASLRAE 252

  Fly   101 ASTKNQENNNMELCDSNTVCIDRRPAEVSQHAMNMAMNSVLNANNTGVGVRVTTACSLFSPLGVL 165
            ...|....:::.:.|.:.:..:........|.:|....::..:|:           ||...|..|
  Rat   253 MELKASGPSDLSISDFSGIQDELHQLRERYHFLNEEYQALRESNS-----------SLTGQLAEL 306

  Fly   166 NNS----ALQREVASECGTLQVSSVPPTSGVDLDIGLESAPTPCKGAAKIVLL-CEPKSHKFETR 225
            .:.    |.:|.:.|......:||...||.:|.     ..|.|.....:..|| .|.:.|..:.:
  Rat   307 ESDRTRRATERWLESHMLKNMMSSESQTSELDF-----PEPDPVMQLLRQQLLGAEEQMHDMQDK 366

  Fly   226 SILLQPNQDCKVGRLIAKSKAGEGNAIFDCKVLSR-----NHAILWYTPDGKFWVKDTKSSNGTF 285
            .    .|..|::..|....:..|.    :.|.|.|     .:.:|      :|....|
  Rat   367 C----KNLCCELEELQHHRRTSEE----EQKRLQRELKCAQNEVL------RFQTCHT------- 410

  Fly   286 INDNKLGS---------DPAELHYGDIVKFGVEV--------------IENSRQEVHGCILARVA 327
            ..:.:|.|         |.::..:.:::|..:::              :|:..::...|.|.::
  Rat   411 TQNEELKSRLCALQQKYDTSQDEHSELLKVQMQLQSELQQLKLVRCTPVESQSEKELMCRLQKL- 474

  Fly   328 LFLPNGQEAISVEAEQMMLTVPN------RISFDEVQRLSSF---LQEAAQREKSLKAKLSSLQG 383
                ..|...||..::.:|.|.:      |....|:.||...   |:|..::...:..:|..::|
  Rat   475 ----QAQHQCSVNEKEQLLEVQHHLHDKLRCHESEMHRLREMVDCLRERNEKNSGIHLQLQEMKG 535

  Fly   384 --------------VLDNTRKNSAMCWQSMITE------------------DQLLHKINILEKKL 416
                          :.|...::..:| |..:||                  |.||.::..|::|.
  Rat   536 LYQCSRDELERQKHMYDQLEQDFMLC-QQELTELKSSHSFCEDSGNRPNKCDALLARLTELQEKF 599

  Fly   417 QMMEKNIPENALRNEIVKLLEDKTTYQ------------LT---AKEALRKVYQERCDAMQMLSK 466
            :..:..|  ..|:.|..:||||:...|            ||   .|..|.:..||....:|.|.:
  Rat   600 KASQLEI--GHLQMEQCELLEDQRRLQEEQGQLQEELHRLTFPQPKCGLLQKSQELLAKLQDLCE 662

  Fly   467 MEMAYATSEN---------ECGILRAQV-----------LTLKQTLTD---------------FN 496
            |::.|...::         || :||.|:           ...::.|.:               |.
  Rat   663 MQLLYQNMQDQQRKLIQNQEC-VLREQLEAHKHLRGFKESNFQEVLANPQDAQGPKSSSCENKFK 726

  Fly   497 TRLEELQQEYMEFKKESVRQEQEAKEQESRSLEVLNGKLTTQELELK-ELRLQVSRIHRDLSESD 560
            ..:|:||.  ::...::.:::||..:||       :|:|..:...|: ||:|.:..:....::|.
  Rat   727 VFMEQLQA--LQVLYDTSQRQQEVLQQE-------HGRLMEERKRLQAELQLCMEEMQLLQTQSP 782

  Fly   561 T-----EHLKERIVLKNLDTINLDDYDHAQDRALNERDDNESSDDDILSVSPAKNVLSETKKRKL 620
            |     ::.|:......|.|   :.:..:.|..::|.:..:.|   .:|..|:|....::....:
  Rat   783 TMKGNFDYCKKNTGSTALST---ESFHRSYDSTIDECEGYQKS---YVSSQPSKETFLKSYDSNM 841

  Fly   621 KLSNPDLEEGNYKSNVLRLLKNSDLGKGEEGSSVLKAIFNGDDEAFECKV--KEEEDMANDSVPT 683
            ..|.. .::....||.....|.|.:    .|||              |:.  |.....:.|..|.
  Rat   842 SCSEA-FQKSYCSSNTTVAYKKSYI----SGSS--------------CETLHKSYASSSTDEEPA 887

  Fly   684 EFVSRNTSEIVDHFKNHSSTTHTILEDSAA----------------TKLSAPNAESKEKLVDVE- 731
            :      .|.::||:...:...|.|:...|                :||.|...|.||:|...|
  Rat   888 D------PEDLEHFEETVAKVLTKLQAVKALYQVSQEEHCQLQERMSKLLAKQKELKEELEYCEK 946

  Fly   732 ------ENLNIPNALPTEQAIDM---------LQEECDTYKKKTAHLTSEIHFLQGQIELLKKQL 781
                  ||...| |.|.....::         ||.:......:...|.:....|:||::..:::|
  Rat   947 ELKECMENFEKP-ATPQNDKCEIKELQTKLRELQLQYQASMDEQGRLLAVQEQLEGQLQCCQEEL 1010

  Fly   782 EKGVDHNFATNLQEEENSLPRET--LELIDNRDSTEGVWNEDIATINNPNVENE-------EELI 837
            .:         |:|..:|...|.  ..::.|.:.......:.:....:.::||:       |.::
  Rat  1011 RQ---------LKENRSSFSSEARGKHVLKNMNKNANGVRDQVGKACSEDLENDFEDEKNLEVML 1066

  Fly   838 VYKELLENSELNNM-QLRKEISELHLKHKHIPFSKQELLCR 877
            .||  ....:|:.: :..||:.||..|.|.....|:  ||:
  Rat  1067 YYK--ASQKKLDELTKEEKEMDELRKKEKEKQAKKE--LCK 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	16/122 (13%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	17/128 (13%)
Ccdc136	XP_006236301.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15715
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030