DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and Slmap

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_006252603.1	Gene:	Slmap / 290533	RGDID:	1307674	Length:	845	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	216/784 - (27%)
Similarity:	367/784 - (46%)	Gaps:	175/784 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 AAKIVLLCEPKSHKFETRSILLQPNQDCKVGRLIAKSKAGEGNAIFDCKVLSRNHAILWYT-PDG 271
            :|..:..|.|.||.|:.|.:.|  ::..|:||.:|:.:..:.||.|||||||||||::|:. ...
  Rat     3 SALAIFTCRPNSHPFQERHVYL--DEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTS 65

  Fly   272 KFWVKDTKSSNGTFINDNKLG-----SDPAELHYGDIVKFGVEVIENSRQEVHGCILARVALFLP 331
            ||:::|||||||||||..:|.     |.|.|:..|||::|||:|.||:|:..||||::.:.||||
  Rat    66 KFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLP 130

  Fly   332 NGQEA----------ISVEAEQMMLTVPNRISFDEVQRLSSFLQEAAQREKSLKAKLSSLQGVLD 386
            :|.||          :....:::....|:..| .|:.:||.:||||..||:.|:.||::||.:|.
  Rat   131 DGMEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQRLLA 194

  Fly   387 NTRKNSAMCWQSMITEDQLLHKINILEKKLQMMEKNIPENALRNEIVKLLEDKTTYQLTAKEALR 451
            .|::.|...||::|.||:||.::.::..:||...||..|::||.|:|.|.|||.:|:.||||:||
  Rat   195 ITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELVALQEDKHSYETTAKESLR 259

  Fly   452 KVYQERCDAMQMLSKMEMAYATSENECGILRA---------------------QVLTLKQTLTDF 495
            :|.||:.:.::.||::|.:.:.:|:||..||.                     ::..|...|...
  Rat   260 RVLQEKIEVVRKLSEVERSLSNTEDECTHLREMNERTQEELRELANKYNGAVNEIKDLSDKLKAA 324

  Fly   496 NTRLEELQQEYMEFKKE--SVRQEQEAKEQESRS-LEVL-------NGKLTT--------QELEL 542
            ..:.||:||:....|||  :...:.|.||||.:: :|.|       |.:||.        ||..|
  Rat   325 EGKQEEIQQKGQAEKKELQAKIDDMEEKEQELQAKIEALQADNDFTNERLTALQVRLEPLQEKTL 389

  Fly   543 KE---LRLQVSRIHRDLSESDTEHLKERIVLKN-LDTINLDDYDHAQDRAL-------------- 589
            ||   |.:||......::.| ||  |||::.|: .|...:..:...|.:.:
  Rat   390 KECSSLGIQVDDFLPKINGS-TE--KERLLSKSGGDCTFIHQFIECQKKLMVQGHLTKVVEESKL 451

  Fly   590 ---NERDDNESSDDDILSVSPAKNVLSETKKR-----------KLKLSNPDLE------EGNYKS 634
               |:....||...|.||.|..|:....|..:           |:.|...||:      |....:
  Rat   452 SKENQAKAKESDLSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGTQAETEAKQDT 516

  Fly   635 NVLR--LLKNSDLGKGEEGSSV-LKAIFNGDDEAFECKVKEEE---------------DMANDSV 681
            ..||  |::..:|.:..:.... |:|:...:.:|:..:|:|..               ||.|
  Rat   517 QHLRKELVEAQELARASKQKCFDLQALLEEERKAYRNQVEESAKQIQVLQVQLQRLHMDMEN--- 578

  Fly   682 PTEFVSRNTSEIVDHFKNHSSTTHTILEDSAATKLSAPNAESKEKLVDVEENLNI---------- 736
                                      |::...|::|:    :::||:..::.:.:
  Rat   579 --------------------------LQEEKDTEISS----TRDKLLSAQDEILLLHQAAAKAVS 613

  Fly   737 ---PNALPTEQAIDMLQEECDTYKKKTAHLTSEIHFLQGQIELLKKQLEKGVDHNFATNLQEEEN 798
               .:.:..::.:..::.|.:.::|..:....||..||...:|..:|.|. .....||.||.|..
  Rat   614 ERDTDFMSLQEELKKVRAELEGWRKAASEYEEEIRSLQSTFQLRCQQCEV-QQREEATRLQGELE 677

  Fly   799 SLPRETLELIDNRDSTEGVWNEDIATINNPNVENEEELIVYKELLENSELNNMQLRKEISELHLK 863
            .|.:| .::::|          :..::...||....||...::.|.||:..:::|..::|.|.:.
  Rat   678 KLKKE-WDVLEN----------ECRSLKKENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMT 731

  Fly   864 HKHI 867
            .|.:
  Rat   732 RKEL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	47/100 (47%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	51/106 (48%)
Slmap	XP_006252603.1	FHA	14..108	CDD:238017	47/99 (47%)
		FHA	<46..109	CDD:224630	38/68 (56%)
		SMC_prok_B	<163..812	CDD:274008	143/608 (24%)
		DUF342	<297..367	CDD:302792	29/90 (32%)
		DUF342	<618..699	CDD:302792	11/45 (24%)
		TMPIT	680..>775	CDD:285135

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4205
eggNOG	1	0.900	-	-		E1_COG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3181
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003045
OrthoInspector	1	1.000	-	-		oto98798
orthoMCL	1	0.900	-	-		OOG6_106606
Panther	1	1.100	-	-	O	PTHR15715
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860