DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and Ccdc136

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001334000.1	Gene:	Ccdc136 / 232664	MGIID:	1918128	Length:	1187	Species:	Mus musculus

Alignment Length:	1027	Identity:	188/1027 - (18%)
Similarity:	350/1027 - (34%)	Gaps:	306/1027 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ELPQTTRYPSGEEPAVKPEEAQYALNMETEKNLEQDNFFHIMDIKEDM-----------ADSNNE 100
            |:.|.......|...::...|..|...|::....||:...:.:..:||           |....|
Mouse   186 EMEQELHLAQAEIQNLRQAAADSATEHESDIASLQDDLCRLQNDLDDMERIRGDYEMEIASLRAE 250

  Fly   101 ASTKNQENNNMELCDSNTVCIDRRPAEVSQHAMNMAMNSVLNANNTGVGVRVTTACSLFSPLGVL 165
            ...|..|.:|:.:.|.:.:..:........:.:|....::..:|:           ||...|..|
Mouse   251 MELKTSEPSNLSISDFSGIQDELHHLRERYNLLNEEYQALRESNS-----------SLTGQLAEL 304

  Fly   166 NNS----ALQREVASECGTLQVSSVPPTSGVDLDIGLESAPTPCKGAAKIVLLCEPKSHKFETRS 226
            .:.    |.:|.:.|......:||...||.:|.     ..|.|.....:..||...:.
Mouse   305 ESDRTRRATERWLESHLLRSTMSSESQTSELDF-----PEPDPVMQLLRQQLLGAEEQ------- 357

  Fly   227 ILLQPNQD------CKVGRLIAKSKAGEGNAIFDCKVLSR-----NHAILWYTPDGKFWVKDTKS 280
              :|..||      |::..|....:..|.    :.|.|.|     .:.:|.:........::.||
Mouse   358 --MQDMQDKCKNLYCELEELQHHRRTSEE----EQKRLQRELKCAQNEVLRFQTSHSTQHEELKS 416

  Fly   281 SNGTFINDNKLGSDPAELHYGDIVKFGVEV--------------IENSRQEVHGCILARVALFLP 331
            ...|.    :...|.::..:.:::|..:::              :|:..::...|.|.::
Mouse   417 RLCTL----QQKYDASQDEHSELLKVQMQLETELQQLRLLRCTPVESQSEKELMCRLQKL----- 472

  Fly   332 NGQEAISVEAEQMMLTVPN------RISFDEVQRLSSF---LQEAAQREKSLKAKLSSLQG---- 383
            ..|...||..::.:|.|.:      |....||.||.|.   |:|..::...:..:|..::|
Mouse   473 QAQHQCSVNEKEQLLEVQHHLHDKLRCHESEVHRLRSMVDCLREKNEKNSGIHLQLQEMKGLYQF 537

  Fly   384 ----------VLDNTRKNSAMCWQSMITE------------------DQLLHKINILEKKLQMME 420
                      :.|...::..:| |..:||                  |.||.::..|:.|.:..:
Mouse   538 SRDELERQKHMYDQLEQDFLLC-QQELTELKSSQSLCEENGNCSNKCDALLARLTELQDKFKASQ 601

  Fly   421 KNIPENALRNEIVKLLEDKTTYQLTAKEALRKVYQERCDAMQMLSKMEMAYATSENECGILR--A 483
            :.|  ..|:.|..:||||:           |::.:|:....:.|.::..    .:.:||||:  .
Mouse   602 EEI--GHLQMEQCELLEDQ-----------RRLQEEQGQLQEELHRLTF----PQPKCGILQKSQ 649

  Fly   484 QVLTLKQTLTDFNTRLEELQQEYMEFKKESVRQEQEAKEQ-----------ESRSLEVL------ 531
            ::|:..|.|.:.....:.:|::.   :|.:..||...|||           ||...|||
Mouse   650 ELLSKLQDLCEMQLLYQNMQEQQ---RKLTQNQECVLKEQLEAHKHLRGFKESHFQEVLANPQDA 711

  Fly   532 -NGKLTTQELELKEL--RLQVSRIHRDLSESDTEHLKERIVLKNLDTINLDDYDHAQDRALNERD 593
             ..|.::.|.:.|.|  :||..::..|.|:...|.|:.               :|.  |.:.||.
Mouse   712 RGPKSSSCENKFKVLMDQLQALQVLYDTSQKQQEVLQR---------------EHG--RLMEERK 759

  Fly   594 DNESSDDDILSVSPAKNVLSETKKRKLKLS-----------NPDLE--EGNYKSNVLRLLKNSDL 645
            ..::.    |.:...:..:.:|:...:|.|           .|..|  ..:|:|::       |.
Mouse   760 RLQAE----LQLCMEEMQVLQTQSPMIKRSFEYCGKNSGSRAPSTENFHRSYESSI-------DE 813

  Fly   646 GKGEEGSSVLKAIFNGDDEAFECKVKEEEDMANDSVPTEFVSRNTSEIVDHFKNHSSTT--HTIL 708
            .:|.:.|.|..   ....|.| .|..:....||::....:.|.:||  |.:.|::.|.:  .|:.
Mouse   814 NEGYQKSYVSS---QPSTETF-LKSYDSSTSANEAFEKSYCSSSTS--VSYKKSYGSVSSGETLH 872

  Fly   709 EDSAATKLSAPNAESKEKLVDVEENLNIPNALPTEQAIDML-----QEECDTYKK------KTAH 762
            ...|::......|| .|.|...||  .:...|...||:..|     :|.|...::      |...
Mouse   873 RSYASSSTDEDPAE-PEDLEHFEE--TVAKVLTKLQAVKALYQVSQEEHCQLQQRMHRLLAKQKE 934

  Fly   763 LTSEIHF-------------------------------------------------------LQG 772
            ||.|:..                                                       |:|
Mouse   935 LTEELQCCEKELRECMESLGKPLPPQSDKCEIKELQTKLRELQLQYQASMDEQGRLLAVQEQLEG 999

  Fly   773 QIELLKKQLEKGVDH-----------NFATNLQEEENSLPRETLELIDNRDSTEGVWNEDIATIN 826
            |::..:::|.:..::           |...|:.:..|.:..:.|.:..:.|...|..||
Mouse  1000 QLQCCQEELRQLKENRPSISSEARGKNVNKNMNKNANGVRNKKLSMACSEDLENGFENE------ 1058

  Fly   827 NPNVENEEELIVYKELLEN-SELNNMQLRKEISELHLKHKHIPFSKQELLCR 877
                :|.|.::.||..... .||  |:..|||.|...|.:.....|.  ||:
Mouse  1059 ----KNLEVMLYYKASQRRLDEL--MKEEKEIEEARKKEREKKAKKD--LCK 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	15/119 (13%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	18/125 (14%)
Ccdc136	NP_001334000.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847520
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940