DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slmap and M4.1

DIOPT Version :9

Sequence 1:	NP_001036397.2	Gene:	Slmap / 3355127	FlyBaseID:	FBgn0040011	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001294342.1	Gene:	M4.1 / 187433	WormBaseID:	WBGene00019766	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	161/566 - (28%)
Similarity:	274/566 - (48%)	Gaps:	71/566 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 IVLLCEPKSHKFETRSILLQPNQD-CKVGRLIAKSKAGEGNAIFDCKVLSRNHAILWYTPDGKFW 274
            :.|:..||||.||.|.|.:..:.| .|:||.:|:.:|...||:||||||||||||||:. ||:||
Worm     6 VSLVATPKSHPFEERRIKVNGSNDPVKIGRAVARIQATAENAVFDCKVLSRNHAILWFR-DGEFW 69

  Fly   275 VKDTKSSNGTFINDNKL-------GSDPAELHYGDIVKFGVEVIENSRQ--EVHGCILARVALFL 330
            :||||||||||:|:.||       .:|...:..|||::.|||::||:.:  .|:|||.|.:..|.
Worm    70 LKDTKSSNGTFVNNEKLQQTVSGRDTDVRRVFSGDIIQLGVEIVENANKVPVVYGCIYAVINCFN 134

  Fly   331 PNGQ-----EAISVEAEQMMLT--VPNRISFDEVQRLSSFLQEAAQREKSLKAKLSSLQGVLDNT 388
            .:|:     ...|.|.::...|  |.||..|    ::..::.||..|||..:.||:.|..::...
Worm   135 ADGKLMENTGPASEEGQRTTTTTLVSNRKLF----QMQQYISEAQHREKQREDKLTELMSIIAAN 195

  Fly   389 RKNSAMCWQSMITEDQLLHKINILEKKLQMM--EKNIPENALRNEIVKLLEDKTTYQLTAKEALR 451
            .:.:...|::::.||:||.:|..||.:|.::  ..|.|:.. :.|::|::::||.::...||.:|
Worm   196 EQAAETAWKALVNEDRLLARIESLEAQLSILSSNNNNPDKQ-KEELLKMIDEKTKFEAKTKEMIR 259

  Fly   452 KVYQERCDAMQMLSKMEMAYATSENECGILRAQVLTLKQTLTD----FNTRLEELQQ---EYMEF 509
            ::.:|..:....|..||.:..|:|.....||::...|:..|.:    |:.:..||:|   :.:|.
Worm   260 RLIEENGETTSRLKDMERSLETTEQTYQQLRSRNEDLETALAETTEMFDAKAAELEQATADLIEK 324

  Fly   510 KKESVRQEQEAKEQESRSLEVLNGKLTTQELELKELRLQVSRIHRDLSESDTE-HLKERIVLKNL 573
            :|.....|::..:.:.::|: |:......|......||..:.|:......:.| ||.       :
Worm   325 QKVVTTYEEKLTDLQQKNLK-LSKSCVINETASGLSRLLANSINSGSFIDEPELHLL-------I 381

  Fly   574 DTINLDDY--DHAQDRALNERDDNESSDDDIL--------SVSPAKNVLSETKKRKLKLSNPDLE 628
            .|:....|  .|.::...:..|::.:||...|        :.|...:..||.||:|.:..:....
Worm   382 STLKSASYLPPHTRETTSSSNDNSSASDSAELHTQLINGFAQSSESSEESEEKKKKPQQQDDKTT 446

  Fly   629 EGNYKSNVLRL-LKNSDLGKGEEGSSVLKAIFNGDDEAFECKVKEEEDMANDSVPTEFVSRNTSE 692
            ...|...:|.| .||.:|    |.::.:         |...:|:|.......|...|.:..:.|.
Worm   447 IEAYLKTILELQAKNREL----EMTAAM---------ATMPEVQENHGCLEASSLKETLEFSPSG 498

  Fly   693 IVDHFKNHSSTTHTILEDSAATKLSAPNAESKEKLV----DVEENL 734
            .|..|.  .|.:..:...|.:|...||..:.:..:|    |..|||
Worm   499 NVSFFP--PSESANLSGSSTSTSSQAPLWQKQATMVMKKPDELENL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slmap	NP_001036397.2	FHA	216..311	CDD:238017	54/102 (53%)
Slmap	NP_001036397.2	FHA	<225..326	CDD:224630	55/110 (50%)
M4.1	NP_001294342.1	FHA	11..113	CDD:238017	54/102 (53%)
M4.1	NP_001294342.1	Smc	<162..>361	CDD:224117	48/204 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159563
Domainoid	1	1.000	91	1.000	Domainoid score	I4885
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003045
OrthoInspector	1	1.000	-	-		oto20221
orthoMCL	1	0.900	-	-		OOG6_106606
Panther	1	1.100	-	-	LDO	PTHR15715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5155
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.800