DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40006 and Scarb2

DIOPT Version :9

Sequence 1:	NP_001036401.1	Gene:	CG40006 / 3355123	FlyBaseID:	FBgn0058006	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_031670.1	Gene:	Scarb2 / 12492	MGIID:	1196458	Length:	478	Species:	Mus musculus

Alignment Length:	456	Identity:	122/456 - (26%)
Similarity:	214/456 - (46%)	Gaps:	32/456 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 IGFLAIITSTLIKVLEPY----DLIFKWKLIMTEGGEIFNLWAQPPVDLYIKIYLFNITNANAFL 157
            :..|.::||..:.|...:    |...:..:::..|.::||.|.:||:.:||:.|.||:||....|
Mouse    12 LSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEIL 76

  Fly   158 AGREQLRVEQVGPYVYKEIMTHENVTFNSN-NTMSSTPSHPLVWQEEMSGNCREDDEVVMLNIAM 221
            .|...| :|:||||.|:|:....|:.|..| .|:|:..:...|::...|......|.:..:||.:
Mouse    77 QGEIPL-LEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPL 140

  Fly   222 LAISHLTANQPFLVRMALKTLLLSTKSEPIVRTTAKEFMFGYPSALATLGNTFLPN-----WISF 281
            |.:..|.  |..|:|..::.:|.:.:.:..|..|..|.::||...:.:|.:.|.|:     .:.:
Mouse   141 LTVVDLA--QLTLLRELIEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHIFKPDVSPNFGLFY 203

  Fly   282 EKVGLIDRMYDFSTDFETFYTGVPNPALSGLYASYRGETTLPQWDGDHCSNIEFASDGTKFKSFI 346
            |:.|..|..|       .|.||..|.........:.|:|:|..|..|.|:.|. .:||..|...|
Mouse   204 ERNGTNDGEY-------VFLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMIN-GTDGDSFHPLI 260

  Fly   347 QPNETVKFFRKSMCRPINLYRVGNEKTYGSLKGYNYVFEDNAFDNGATNEANKCFC-RKGDCQPV 410
            ..:|.:..|...:||.:::.....|...| |..:.|........|  |:| |..|| .:|:|...
Mouse   261 SKDEVLYLFPSDLCRSVHITFSSFENVEG-LPAFRYKVPAEILAN--TSE-NAGFCIPEGNCMDS 321

  Fly   411 GLIDVTDCYYGFPISLSFPHFMNGDVGLQQNVTGISPDPDKHSSTFVIQPESGLPLSLSVKVQIN 475
            |:::::.|..|.||.:|||||...|......:.|:.|:.::|.|...|.|.:|:.|..:.:.|||
Mouse   322 GVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQIN 386

  Fly   476 MHFKDLSNFPVVSVFNHLTVPMLWF--EIMMSK-LPDSLDSRFNFYL---NILPLVNPLGFWSGI 534
            .:.:.|.:|........:..|:::.  .:::.| ..:.|.|..|..|   ||..::..||.:.|:
Mouse   387 TYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTTLVVTNIPYIIMALGVFFGL 451

  Fly   535 L 535
            :
Mouse   452 V 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40006	NP_001036401.1	CD36	91..545	CDD:279474	122/456 (27%)
Scarb2	NP_031670.1	CD36	28..455	CDD:279474	118/440 (27%)
Scarb2	NP_031670.1	Important for interaction with GBA	155..191		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920