DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40006 and Cd36

DIOPT Version :9

Sequence 1:	NP_001036401.1	Gene:	CG40006 / 3355123	FlyBaseID:	FBgn0058006	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001153027.1	Gene:	Cd36 / 12491	MGIID:	107899	Length:	472	Species:	Mus musculus

Alignment Length:	475	Identity:	119/475 - (25%)
Similarity:	222/475 - (46%)	Gaps:	63/475 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 VIG-FLAIITSTLIKVLEPYDLI----FKWKLIMTEGGEIFNLWAQPPVDLYIKIYLFNITNANA 155
            ||| .||:....|:.|   .|::    .|.::::.||...|..|.:....:|.:.::|::.|.:.
Mouse    14 VIGAVLAVFGGILMPV---GDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDD 75

  Fly   156 FLAGREQLRVEQVGPYVYK-EIMTHENVTFN-SNNTMSSTPSHPLVWQEEMSGNCREDDEVVMLN 218
            ......:::|:|.|||.|: ..:..||:|.: .::|:|....:..:::..:|.. .|||...:||
Mouse    76 VAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVG-TEDDNFTVLN 139

  Fly   219 IAMLAISHLTANQPFLVRMALKTLLLSTKSEPIVRTTAKEFMFGY--------PSALATLGNTFL 275
            :|:.|..|:..|.  .|::.|.:|:..:||......:.||.::||        |..::|....|.
Mouse   140 LAVAAAPHIYQNS--FVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFY 202

  Fly   276 PNWISFEKVGLIDRMYDFSTD--FETFYTGVPNPALSGLYASYRGETTLPQWDGDHCSNIEFASD 338
            |              |:.:.|  ::.| .|..|.:...:..||:|:..|..|. .:|..|. .:|
Mouse   203 P--------------YNDTVDGVYKVF-NGKDNISKVAIIESYKGKRNLSYWP-SYCDMIN-GTD 250

  Fly   339 GTKFKSFIQPNETVKFFRKSMCRPINLYRVGNEKTYGS---LKG---YNYVFEDNAFDNGATNEA 397
            ...|..|::.:.|::||...:||  ::|.|     :||   |||   |.:|...|||.:...|..
Mouse   251 AASFPPFVEKSRTLRFFSSDICR--SIYAV-----FGSEIDLKGIPVYRFVLPANAFASPLQNPD 308

  Fly   398 NKCFCRK----GDCQPVGLIDVTDCYYGFPISLSFPHFMNGDVGLQQNVTGISPDPDKHSSTFVI 458
            |.|||.:    .:|...|::|:..|..|.|:.:|.|||::....:.:.:.|:.|:.|:|.:...:
Mouse   309 NHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDV 373

  Fly   459 QPESGLPLSLSVKVQINMHFKDLSNFPVV-SVFNHLTVPMLWFEIMMSKLPDSLDSRFN-FYLNI 521
            :|.:|..|..:.::|:|:..|.......: ::.....||:||    :::.....|.:.. |...:
Mouse   374 EPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILW----LNETGTIGDEKAEMFKTQV 434

  Fly   522 LPLVNPLGFWSGILLGISLL 541
            ...:..||.....||||.::
Mouse   435 TGKIKLLGMVEMALLGIGVV 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40006	NP_001036401.1	CD36	91..545	CDD:279474	119/475 (25%)
Cd36	NP_001153027.1	CD36	16..463	CDD:366481	117/473 (25%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:15748999	93..120		6/26 (23%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810