DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40006 and Scarb2

DIOPT Version :9

Sequence 1:	NP_001036401.1	Gene:	CG40006 / 3355123	FlyBaseID:	FBgn0058006	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_446453.1	Gene:	Scarb2 / 117106	RGDID:	621882	Length:	478	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	124/456 - (27%)
Similarity:	211/456 - (46%)	Gaps:	32/456 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 IGFLAIITSTLIKVLEPY----DLIFKWKLIMTEGGEIFNLWAQPPVDLYIKIYLFNITNANAFL 157
            :..|.::||..:.|...:    |...:..:::..|.::|:.|.:||:.:||:.|.||:||....|
  Rat    12 LSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFYFFNVTNPEEIL 76

  Fly   158 AGREQLRVEQVGPYVYKEIMTHENVTFNSN-NTMSSTPSHPLVWQEEMSGNCREDDEVVMLNIAM 221
            .|...| :|:||||.|:|:....||.|..| .|:|:..:...:::...|......|.:..:||.:
  Rat    77 QGEIPL-LEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIPL 140

  Fly   222 LAISHLTANQPFLVRMALKTLLLSTKSEPIVRTTAKEFMFGYPSALATLGNTFLPN-----WISF 281
            |.:..: |.|||| |..::.:|.:.:....|..|..|.::||...:.:|.:.|.|:     .:.:
  Rat   141 LTVVEM-AQQPFL-REIIEAMLKAYQQTLFVTHTVHELLWGYKDEVLSLVHIFRPDVSPNFGLFY 203

  Fly   282 EKVGLIDRMYDFSTDFETFYTGVPNPALSGLYASYRGETTLPQWDGDHCSNIEFASDGTKFKSFI 346
            |:.|..|..|       .|.||..|.........:.|:|:|..|..|.|:.|. .:||..|...|
  Rat   204 ERNGTNDGEY-------VFLTGEDNYLNFTKIVEWNGKTSLDWWTTDTCNMIN-GTDGDSFHPLI 260

  Fly   347 QPNETVKFFRKSMCRPINLYRVGNEKTYGSLKGYNYVFEDNAFDNGATNEANKCFC-RKGDCQPV 410
            ..:||:..|....||.:.:.....|...| |..:.|........|.:.|..   || .:|:|...
  Rat   261 SKDETLYIFPSDFCRSVYITFSSFENVEG-LPAFRYKVPAEILANSSENAG---FCIPEGNCMDA 321

  Fly   411 GLIDVTDCYYGFPISLSFPHFMNGDVGLQQNVTGISPDPDKHSSTFVIQPESGLPLSLSVKVQIN 475
            |:::|:.|..|.||.:|||||...|......:.|:.|:.::|.|...|.|.:|:.|..:.:.|||
  Rat   322 GVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAKRFQIN 386

  Fly   476 MHFKDLSNFPVVSVFNHLTVPMLWF--EIMMSK-LPDSLDSRFNFYL---NILPLVNPLGFWSGI 534
            .:.|.|.:|........:..|:::.  .:::.| ....|.|..|..|   ||..::..||.:.|:
  Rat   387 TYVKKLDDFVETGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIMALGVFFGL 451

  Fly   535 L 535
            :
  Rat   452 I 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40006	NP_001036401.1	CD36	91..545	CDD:279474	124/456 (27%)
Scarb2	NP_446453.1	CD36	34..457	CDD:395898	120/434 (28%)
Scarb2	NP_446453.1	Important for interaction with GBA. /evidence=ECO:0000250	155..191		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920