DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht10 and lmd-4

DIOPT Version :9

Sequence 1:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster
Sequence 2:	NP_504862.2	Gene:	lmd-4 / 179121	WormBaseID:	WBGene00017233	Length:	2011	Species:	Caenorhabditis elegans

Alignment Length:	1632	Identity:	318/1632 - (19%)
Similarity:	532/1632 - (32%)	Gaps:	609/1632 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 LATPVPPQMTTISSDGSGGLGQNHDHTTSLPSGQISSSPVSTTITSTFPWWS------------- 656
            :.|||..|..|.||...|      :::|..|:||...........:.|..||
Worm   604 VTTPVSGQSRTTSSSNQG------NNSTRAPTGQCEQKIKVKEGDTCFKIWSAQKMTEQQFMEMN 662

  Fly   657 ----------------------------STTKRPREPTKTTA---------QPTHT--TILIPAG 682
                                        |.|.:|..|...|:         .|.:|  .|.:..|
Worm   663 RGLDCNKLMVGKEVCVSGGSNPGSPEENSNTTKPALPMVETSGTCNEYATITPGNTCFNISVAYG 727

  Fly   683 IN--PVVQPSNCKS---GEFFADSNNCNAYYH--------CFF------AGELQQQFCPSGLHWN 728
            ||  .:.:..:||:   |:....|.|....:.        |:|      ..:.:.:....|:..:
Worm   728 INLTDLQKTYDCKALEVGDTICVSQNYTCQHRIEVIKGDTCWFLENAFKTNQTEMERANEGVKCD 792

  Fly   729 NEAKG---CDWPSSAQCSLKLDQHLSTSYPNPIQTSKKPETTLKPNKKPSEISTHHQVNS-TSSR 789
            |...|   |.|.:.       |:.|    ||...|..|   |:  |.:.|:.....:.:| |...
Worm   793 NLPIGRMMCVWSAD-------DRKL----PNMTCTEWK---TM--NDESSDCYGEARNSSITIDL 841

  Fly   790 PQYMRPTILECTEGDYYPH-----------RNC------RKYYICVNKALVPSECGGDLHWDGIK 837
            .:::.|.: .||.....|.           :||      .:|..| |:.:..::.       .::
Worm   842 FKFLNPRV-NCTNRQKIPKGSKICVKSQSTKNCTSIQMFNQYQSC-NQVMQQNQI-------SMR 897

  Fly   838 KLCDWPENVQCVTSKKYLKIIKSSSANEEDPCKGEKRV-PYPGNCSKY--LFCLWNRLQASDCPP 899
            ||.|.....:|...:|..:|...:...:::.|...:|| |...||.|.  |..| :|.|.....|
Worm   898 KLMDLNPTFRCDRLQKSEQICLGTGPFKQEQCISSRRVTPENDNCEKITRLTGL-SRGQIETLNP 961

  Fly   900 GLHYNERIGNCDW----------------------------PAAAKC----NPKGSESSEEA--- 929
            |:...:..   :|                            |...|.    |...||::|.|
Worm   962 GIKCEKPF---EWGSLICTASLGVDTRQAQDLIVTSLKDIAPELVKMFDNYNSNPSEANENAMNE 1023

  Fly   930 ELNA-MPKPPTPQTPSSHLRPTYPTEKPV--------PKPRDSHYKVI-----------CYFTNW 974
            ||.| :.||..    :|.|:..|.:::.:        |.||:.:.:.|           ||..|
Worm  1024 ELLADLQKPAV----NSKLKELYKSDEKIRKILDSQHPLPREKYCEEIKKTKMSDNIKNCYCEN- 1083

  Fly   975 AWYRKGIGRFTPDDINTELCTHVIYGFAVLDYSELVLRTHDSWADVENNFYTRVTSLKSKGIKVS 1039
                                            .||:|             |.:|.:.|
Worm  1084 --------------------------------EELLL-------------YCQVLATK------- 1096

  Fly  1040 LALGG--WNDSQGDKYSRLVRSPMARSRFVRHALE-----------FIEKYG--FEG-------- 1081
            :.|.|  ||..|.....|..||    .|.|..:..           |...||  |.|
Worm  1097 VILDGEDWNSPQNTTVLRAFRS----KRQVGCSFSTPSSGEDTLSVFKNLYGGCFAGGCTFPFGL 1157

  Fly  1082 LDLDWEYPVCW----------------QTECNKGSTEEKDGFTAWVQELSEAFRPRGLMLSTAVS 1130
            :::..|..:|.                :.:|.|...|:..|    ::.|::  |..|.::|....
Worm  1158 VEISVEADICVPSVTFAKDTVLYCAKDKNDCTKKENEDVPG----LKYLAD--RKLGGVISLCAV 1216

  Fly  1131 PSR--KIIDAGYDIPQLSRYFDWIAVMTYDFHGHWDKKTGHVAPLYHHPDDDFEYFNVNYSINYW 1193
            .|:  |::..|    .||..::.:|...:.|.|..|..:
Worm  1217 GSKLAKLLTKG----GLSLCWEILAADYFGFIGKLDLSS-------------------------- 1251

  Fly  1194 MEKGAPSQKLVMGIPLYGQSFTLENTNSSGLNAKAPAPGEAGEFTRAAGFLAYYEICERVNRQ-- 1256
                  :.:||:                        ...|.|...:..| ||:.::||....|
Worm  1252 ------NLRLVV------------------------VDVEGGATMKVHG-LAFPDMCEHSEFQCE 1285

  Fly  1257 ---GWQVVHDEFGRMGPYAY-----------KGTQWV--SYDSPDMV-----RKKSLLVRSLKLG 1300
               .|:.  ||:.....|.|           .|.:.:  |:|.|..|     ::.::::|:.:..
Worm  1286 DYCRWRA--DEWDNGKAYGYLKFKALKVFGFSGFKLLEESFDEPSRVGCDEGKEAAVVLRNTRTC 1348

  Fly  1301 GGMVWALDLDDFKNRCGNGVHPL--------------------------LTEIHNVLKDPPSLME 1339
            ......    :.:.||.:|...:                          .|:.||        .:
Worm  1349 KDQAER----EIQRRCWSGDDMMGWDKLDKEWSFAFQPHIFGRTLFVCEFTDKHN--------QK 1401

  Fly  1340 IPGPIETTPTEYPGMEEE--------IHESNG--EGPEVQPIEAVMQTCENEGEEHE---GILDP 1391
            |...:      |.|..:.        :.:::|  .|.|....:.:|.:.:|:.||.:   ...||
Worm  1402 IGFDV------YGGKSDNKGKATFYYVVKNDGIYFGTEKYKEDKLMGSWDNKCEEDKPEPPKPDP 1460

  Fly  1392 NHVLEEENIEATEMATEFK-IICYFTNWAWYRQGGGKFLPEDIDSDLCTHIIYGFAVLSRDNL-- 1453
            :.|.|.....:...|:..| |:.|:|.|      |.:.:.|:....| ||:|:.|..:..|..
Worm  1461 SKVEEPTGKSSLPAASCGKRIVGYYTGW------GDREITENQLKKL-THVIFAFVAMYEDGSVK 1518

  Fly  1454 --TIQPHDSWADLDNKFYERIVAYRKK------GAKVTVAIGGWNDSAGDKYSRLVRNPEARSRF 1510
              .:...||......|...|.:..:||      |.:|..|:|||::|  ..:|.:..:...|.:|
Worm  1519 FGAVSEDDSGPQAAKKAERRFLNMKKKARAANSGVRVLFAVGGWDNS--QYFSSVAADSGKRKKF 1581

  Fly  1511 IRNVLDFIEEYNFDGLDLDWEYPVCWQVDCKKGTAEEKIGFSALVRELFYAFQPR-----GLILS 1570
            :.::..|:|:...||:|||||||     |.....|:..:.....:||.|.....:     ..:::
Worm  1582 VDSIASFVEDQKIDGVDLDWEYP-----DSNGKDAKNHVQLIKEIREKFSEMAKKKKRKDPYVIT 1641

  Fly  1571 AAVSPNKKVIDAGYEVAELSHYFSWISVMAYDYHGQWDKK----TGHVAPMY--SHPEGTANFNA 1629
            .|.:..:..:..||::..:..|..:|:||.|||:|.|:.|    ||..||:|  |....:...||
Worm  1642 LASAAGEWNLRKGYDLKGILKYADFINVMTYDYYGAWESKWGAYTGTPAPLYFGSLKGFSGKLNA 1706

  Fly  1630 NFSMNYWISMGADRRKLVMGIPLYGQSFS--LAETTKH----QLNAP---TYGGGEAGEATRARG 1685
            :|||.::........:|.||:|.||:.:.  |....|.    :..||   .|.||..|....|:
Worm  1707 DFSMKFYACKTEKPSQLNMGVPFYGRYWKNVLGPIDKSDNMWRTAAPQNGKYEGGYVGWRNLAK- 1770

  Fly  1686 FLAYYEICLKIRHHRWNVVRDTKGRIGPFAYH------------GDQWVSFDDVPMIRHKSEYIK 1738
                         ..||.        |..::|            ..:::.|::...::.|.:|..
Worm  1771 -------------EGWNK--------GSASWHEKTKTPYIMNNGAKKFLGFENERSLKEKMKYAT 1814

  Fly  1739 AMGLGGAMIWALDLDD----------FKNVC--------------------------------EC 1761
            ...|||.|||||||||          ...:|                                :|
Worm  1815 DRNLGGLMIWALDLDDDADTLLNLVSSAGLCSGGKGDKVTYKCVPIDDVRWWTPENSDEKKQGQC 1879

  Fly  1762 -ESYPLLKAINRVL----RGF---------GGPQPKCLLENPKSTMK-PN--IKPPFRP------ 1803
             :|.||:.....|.    .||         |..:..|..:...:..| |:  ||.|.:|
Worm  1880 GKSAPLINGFYPVCDPDDPGFSCCGAAGYCGSGKEYCDCKGCVNYRKDPDLIIKKPVKPSREIQW 1944

  Fly  1804 -TINAPS------GPNLDSPTQNVSLNVLSIKCHSKNYLAHEWDCTKYYICEHGTYVERSCPLGL 1861
             |.:||.      |.:::             |.:.|..:.:..|.|| |.|.:|.|    |.:|
Worm  1945 YTQDAPDGKRGRCGKDIE-------------KINGKMPICNPDDDTK-YCCSNGGY----CGIG- 1990

  Fly  1862 QWNKTYC 1868
               |.:|
Worm  1991 ---KEFC 1994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696	8/56 (14%)
		CBM_14	801..848	CDD:279884	10/63 (16%)
		CBM_14	875..918	CDD:279884	13/73 (18%)
		Glyco_18	966..1310	CDD:214753	65/418 (16%)
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351	71/464 (15%)
		Glyco_18	1410..1753	CDD:214753	100/385 (26%)
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351	107/447 (24%)
		ChtBD2	1834..1871	CDD:214696	11/35 (31%)
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
lmd-4	NP_504862.2	LysM	25..65	CDD:197609
		LysM	79..120	CDD:197609
		LysM	142..185	CDD:197609
		LysM	209..250	CDD:197609
		LysM	270..313	CDD:197609
		LysM	334..377	CDD:197609
		LysM	401..444	CDD:197609
		LysM	469..509	CDD:197609
		LysM	550..590	CDD:197609
		LysM	635..678	CDD:197609	3/42 (7%)
		LysM	710..750	CDD:197609	9/39 (23%)
		LysM	760..802	CDD:197609	5/41 (12%)
		LysM	876..919	CDD:197609	9/50 (18%)
		Self-incomp_S1	1359..1433	CDD:283566	11/87 (13%)
		Glyco_18	1480..1825	CDD:214753	95/380 (25%)
		GH18_chitinase-like	1481..1824	CDD:299167	94/378 (25%)
		ChtBD1_GH18_2	1873..1924	CDD:211315	9/50 (18%)
		ChtBD1_GH18_2	1951..2002	CDD:211315	14/66 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4747
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740