DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht10 and CTBS

DIOPT Version :9

Sequence 1:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster
Sequence 2:	NP_004379.1	Gene:	CTBS / 1486	HGNCID:	2496	Length:	385	Species:	Homo sapiens

Alignment Length:	418	Identity:	96/418 - (22%)
Similarity:	163/418 - (38%)	Gaps:	91/418 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 LRPTYPTEKPVPKPRDSHYKVICYFTNWAWYRKGIGRFTPDDINTELCT----HVIYGFAVLDYS 1007
            ||....|:.|.|:|                               |||.    |..:...|.|..
Human    33 LRLAAGTDCPCPEP-------------------------------ELCRPIRHHPDFEVFVFDVG 66

  Fly  1008 ELVLRTHDSWADVENNFYTRVTSL-----------KSKGIKVSLALGGWNDSQGDKYSRLVRSPM 1061
            :...:::| |:.:     |.|.:.           .|||.:|.|        :||...:.:..|.
Human    67 QKTWKSYD-WSQI-----TTVATFGKYDSELMCYAHSKGARVVL--------KGDVSLKDIIDPA 117

  Fly  1062 ARSRFVRHALEFIEKYGFEGLDLDWEYPVCWQTECNKGSTEEKDGFTAWVQELSEAFRP--RGLM 1124
            .|:.::...|...:....:|:::|.|..|    .|   .:.|.|..||.|:|.:::|..  .|..
Human   118 FRASWIAQKLNLAKTQYMDGINIDIEQEV----NC---LSPEYDALTALVKETTDSFHREIEGSQ 175

  Fly  1125 LSTAVSPSRKIIDAG-YDIPQLSRYFDWIAVMTYDFHGH-WDKKTGHVAPLYHHPDDDFEYFNVN 1187
            ::..|:.|.|.||.. |:...::...|::.||:||.... |.:........|:.....:..: :.
Human   176 VTFDVAWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYNDY-IK 239

  Fly  1188 YSINYWMEKGAPSQKLVMGIPLYGQSFTLENTNSSGLNAKAPAPGEAGEFTRAAG-FLAYYEICE 1251
            .|||        .:|||||:|.||..:|..|.:...:...|..|......:.||| .:.|..|.:
Human   240 MSIN--------PKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPFRGAPCSDAAGRQVPYKTIMK 296

  Fly  1252 RVNRQGWQVVHDEFGRMGPYAYKGT----QWVSYDSPDMVRKKSLLVRSLKLGGGMVWALDLDDF 1312
            ::|......:.|:..|...|.||..    ..|.||:|..:..|:..:::.:|.|..:|..:..|:
Human   297 QINSSISGNLWDKDQRAPYYNYKDPAGHFHQVWYDNPQSISLKATYIQNYRLRGIGMWNANCLDY 361

  Fly  1313 KNRCGNGVHPLLT-EIHNVLKDPPSLME 1339
            .   |:.|....| |:..|||  |.|::
Human   362 S---GDAVAKQQTEEMWEVLK--PKLLQ 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696
		CBM_14	801..848	CDD:279884
		CBM_14	875..918	CDD:279884
		Glyco_18	966..1310	CDD:214753	80/367 (22%)
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351	85/388 (22%)
		Glyco_18	1410..1753	CDD:214753
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351
		ChtBD2	1834..1871	CDD:214696
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
CTBS	NP_004379.1	GH18_chitobiase	39..378	CDD:119354	89/402 (22%)
CTBS	NP_004379.1	Glyco_18	<115..358	CDD:214753	63/258 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8303
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D826687at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770