Protein Alignment FASN3 and fasn

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: XP_009305081.1
• Gene: fasn / 559001
• ZFINID: ZDB-GENE-030131-7802
• Length: 2511
• Species: Danio rerio
• Alignment Length: 2579
• Identity: 953/2579 - (36%)
• Similarity: 1459/2579 - (56%)
• Gaps: 312/2579 - (12%)

  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKICDLEKFDATFFG 83
            :||||:|::|:.|...|:.|:...|:|.:|||.:|:|||:.....:|:|:||:.::::|||.|||
Zfish     2 EDIVIAGISGRLPESNNLEEFWQNLFNGVDMVTEDDRRWKPGLYGLPRRNGKLKEIDRFDAAFFG 66

  Fly    84 VHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGGFG 148
            ||.|||||||||.|:::|.:|||::|.|:||.|:||||||||||...||:.:.:..:.....|:.
Zfish    67 VHPKQAHTMDPQLRLMLEISYEAIVDGGINPVSMRGSKTGVYIGVSGSEAGEAFSKDPEELLGYS 131

  Fly   149 ITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHPFV 213
            :|||.|||.|||:||.....|||..:|||||||:.||:|||:|||:|:.|||:|||.||||.|..
Zfish   132 MTGCQRAMFANRLSYFFDFNGPSTAIDTACSSSLLALENAFNAIRHGKCDAALIGGVNLLLKPNT 196

  Fly   214 TLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPEGI 278
            ::||.:||:|:|:|.|:.||.:.:||.|||....:.|.||..|||:||:::.:..|.||||.:|:
Zfish   197 SVQFMKLGMLSPEGTCKSFDASGNGYCRSEAAVAVLLTKKSMAKRIYATVLNAGNNTDGYKEQGV 261

  Fly   279 TYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGSVK 343
            |:|||.:|::|:...|::.:..|..:.|:|||.|||.||||:|...|.:|.|..:.:|||:||.|
Zfish   262 TFPSGEMQQRLVRSLYQEANISPEQVEYIEAHGTGTKVGDPQEVNGIVSVFCQSQRDPLLIGSTK 326

  Fly   344 SNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIGIN 408
            ||:||.|.|||:.:|.|...:.|.|:.|||::|.|....|..|.:|||.||....|:....:|||
Zfish   327 SNMGHPEPASGLAALAKVVLSLEHGVWAPNVHFNEPNPDIPALTDGRLCVVSKPTPVRGGIVGIN 391

  Fly   409 SFGFGGANAHALLKGYPKSKNNFGIPADDVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFIGLLQ 473
            ||||||:|.|.:|..: .|.::...||..|||||..:|||||||..:|:..:::..::.::.||.
Zfish   392 SFGFGGSNVHVILSPH-VSDSSDKTPAPSVPRLLQASGRTEEAVTALFSNAQQHQENSSYLSLLN 455

  Fly   474 NIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSLMIIP 538
            ::.....:||.:|||.:...||.      ..:||......||:.::.||||:||..||.|||.:.
Zfish   456 DVSGVPTAGMPYRGYTLIGAQGE------LTEVQQTQPTPRPLWYICSGMGTQWAGMGQSLMQLS 514

  Fly   539 RFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPDYIIG 603
            .||||::.....|...||.:..:|...|...:::.:::|||:||:|:...|:||.:.::|:.|:|
Zfish   515 EFRESIKRSDIALKDTGLCVSRLLMEADESTFEDTVHAFVGLAAIQVAQIDMLRKMGLEPNGIVG 579

  Fly   604 HSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIETACHN 668
            ||||||.|.||||.|:..:.|||||:|||...:.....|.||||||.::......|:.:..||||
Zfish   580 HSVGELACGYADGSLSHSEAILAAYWRGRCIKEANLPPGGMAAVGLTWEECKAQCPQGVVPACHN 644

  Fly   669 GPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHPKPRT 733
            ..|:.|||||.|.|::|||.||..|:|||||..:.:|:||.|::.:.|.||:.:.::|..|:|||
Zfish   645 AEDTVTISGPQDSVSKFVAQLKESGVFAKEVRSAGVAFHSYYMASIAPALLSALQKVIKSPRPRT 709

  Fly   734 KKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAILKRS 798
            .:|:|||:|:.||....|.:.|||||.|||::.|||.|..:.:|.|::.:|:|||.||.||||||
Zfish   710 ARWISTSIPQSDWESPLALYSSAEYHVNNLVSPVLFQEGLNHVPDNAVVVEIAPHALLQAILKRS 774

  Fly   799 M-PSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIRWDHS 862
            : |:...:||..||:.||..||||.:||:|:||:.:.:..||..:::||.|.||.:|..|:||||
Zfish   775 LKPTCSILPLMKRGHANNLEFFLSHVGKVYMNGINVDSNKLYPAVKYPVPRGTPLISPYIQWDHS 839

  Fly   863 EDWFVTKYENMKTKSSGE---RVFSVNLASDNEE-FLSGHIIDGKILVPATCYLQYVWETFSLMY 923
            :.|.|.|.|:....|.|.   .|:::::..::.: ::.||.|||::|.|||.||...|.|  ||.
Zfish   840 QSWDVPKVEDFPAGSGGSTSATVYNIDMNPESPDYYMIGHCIDGRVLYPATGYLVLAWRT--LMR 902

  Fly   924 HGPSYMD-VPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETENPSI 987
            ...:.|| .||.|||:...|||.:|..|.|.|.|.:...|..||::|.|:|.|:|.:...|:..:
Zfish   903 SLGTVMDHTPVTFEDVTIHRATILPKTGSVQLEVRLMPATNRFEVSENGNLAVSGKVSVLEDSGL 967

  Fly   988 PEVYNFQSKSKFPMIAKK----------DFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNYN 1042
            ..   |.::...|:.|..          |.||||:||||.|...||.:..:.:.|..|::.|..|
Zfish   968 DA---FHAELNKPITADNEDPKLRLKSGDIYKELRLRGYDYGKTFQGILESNNAGDSGKLHWTGN 1029

  Fly  1043 WVTFMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRVFDVYVDPMYDRIIAG 1107
            ||||:|.|||:.::|...|:|.|||:||.:.::...|.:.:...:.:.:..:|:|:...|.|.||
Zfish  1030 WVTFLDTMLQMIVVGLPGRSLRLPTRIRSVCVDPKLHEERVNDYEGDQKAVNVFVNRCLDNITAG 1094

  Fly  1108 GIEIFGLHASLVQRRRPPGI-PVLEEYVFLPFFSS------------------------------ 1141
            |::|.||||:...||:.... |.|||:||:|:..:
Zfish  1095 GVQICGLHATAAPRRQQQQTPPTLEEFVFVPYEDADCLRTNEKLADQLRHCKGLVQRLQRKLAKQ 1159

  Fly  1142 ----SILSLKNAA---------------------------------------------------- 1150
                ||..|:.|:
Zfish  1160 GVKISIPGLEGASEGQLIEAEAEKGLLRLLSVLCGLELNGNLRSELEQTVQKERDCLLQDPLLNG 1224

  Fly  1151 -------RVCVQIAIENNPTLKLKLVE-VGADGKNHMLTEFIEAIQDLPVITGDYIL-------L 1200
                   |.|:..|:||:...|.|::| :.|||:  :.::.:..:...|::..||..       |
Zfish  1225 LLDSQALRHCLDTALENSTPGKFKVLEALAADGR--VFSQAVSLLNIQPMLRLDYTASDISADQL 1287

  Fly  1201 TSQ--NLED------------------LPGVHIE--NGSLSTQTNCHIIIIGGYEEDEVHEKITS 1243
            ::|  :||:                  |.|..:.  |.::.:.||..::|          |.:||
Zfish  1288 SAQQSSLEEQGISTAQWDPLQGPVTGGLDGADLVVCNCAVGSATNPALLI----------ENLTS 1342

  Fly  1244 AYNVLVDNGYIVFRQKCAKNVSCKIAEKFRTISKIPINNTEENLV-------LLQKISKKLTV-- 1299
            |..   :.|:|:.......:.   :.|   |::.:...|..:.|:       |.||.|..:.:
Zfish  1343 AAR---EGGFILLHTLLRGDT---LGE---TVAFLTSQNNRKGLLTQTEWEELFQKASLNVVMLR 1398

  Fly  1300 --------------------PPVLVKVSQHDKTFEWILELQSAIITKAPVVVYSFNEK-LNGQIG 1343
                                .|:.:.|...|  ::|:..|:|.:...:.:.|:....| .||.:|
Zfish  1399 KSYYGSALFLCRRSQQSSQKQPIHIFVDPTD--YKWVETLKSTLAESSDIPVWLIATKGHNGVVG 1461

  Fly  1344 LVNCLRKEPDGNLIRCFFIDDDS----APDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLL 1404
            :|||||:||.||.|||.|:.:.|    .|....:...........|..|::|:|.||.:|| |||
Zfish  1462 MVNCLRQEPGGNRIRCTFVSNLSKGAAVPSLLPNEKVMKALLKKDLVMNVHRDGLWGVFRH-QLL 1525

  Fly  1405 KNDQPSKRLDHIYGNVIQRGDLSSLQWLKGPF--------NSQNCHIKIAFSSLNFRDVMLATGR 1461
            ..|...:..:..|.||:.|||||||:|:..|.        |.|.|  ::.:|||||||:|||||:
Zfish  1526 TQDLSEELTEQAYVNVLTRGDLSSLRWIASPLRHFVASSPNVQLC--RVYYSSLNFRDIMLATGK 1588

  Fly  1462 LAVELYGSSRIDQNCVLGFEYSGINMLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAA 1526
            |..:........|.|:||.|:||.:. :|||:|.::...|:|:.|:...:.:||:|..|:||:||
Zfish  1589 LPPDAIPGDVALQQCMLGMEFSGRDP-SGRRVMGLLPAKGLATCVDADKRFLWDVPSSWTLEQAA 1652

  Fly  1527 TVPVVYITVYYAFFMATDIRKGKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKT 1591
            :|||||.|.||:..:...:|.|:|:|||:|:||:|.|||.:||:....||||..:..||::|.:.
Zfish  1653 SVPVVYATAYYSLVVRGRLRPGESVLIHSGSGGVGQAAIAIALSMRCRVFTTVGSKEKKQYLQER 1717

  Fly  1592 FPKLKESHIGNSRNTSFELMVHRETNGKGVDFVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMAN 1656
            ||:|......|||::|||..|...|.|||||.|||||:||||.||||||.:.|.||||||||::|
Zfish  1718 FPQLTAESFANSRDSSFEQHVMLNTQGKGVDLVLNSLAEEKLQASLRCLARHGRFLEIGKYDLSN 1782

  Fly  1657 DNKIGLGCFLKEITFHAVLADSLLVAPDEDIWHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFR 1721
            :..:|:..|||.:.||.:|.|:|....:.:...:..|:...||:|::|||...||..:::|:|||
Zfish  1783 NTPLGMALFLKNVAFHGILLDALFEEGNREWEEVSDLLKKGISSGVVQPLRTTVFERNQVEEAFR 1847

  Fly  1722 HLIGGKHIGKVVIQVREQPHDP-----STLPVRVLNQVYFKHNHTYVIPGGLGGFGMELADWMAI 1781
            ::..|||||||::|||.:....     |.|.:..:.:.:...:.:|:|.|||||||:|||.|:..
Zfish  1848 YMAQGKHIGKVLLQVRSEESSSSGPAVSALSIPAICRTFCPASLSYIITGGLGGFGLELAQWLTE 1912

  Fly  1782 RGARKLLLSSSRGITKDYQLYRIALWKTYGCEVAISTADITSKKGCAQLLSEANGMGPVGGIFNL 1846
            ||||||:|:|..||...||..|:..|:..|.:|.:||:|:::..|..:|::||..:|||||||:|
Zfish  1913 RGARKLVLTSRSGIRNGYQAKRVREWQAMGIQVLVSTSDVSTLDGTERLITEACRLGPVGGIFHL 1977

  Fly  1847 AVVLKDCIFSNQNVNQFLECFAPKAIATTYLDDLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGM 1911
            |:||||.:..|....:|:|...||...|..||.::|..||:|:.||||||||||||||||||||.
Zfish  1978 AMVLKDGMLENLTPQEFIEVNRPKYDGTINLDSVTRQKCPQLQQFVVFSSVSCGRGNAGQSNYGF 2042

  Fly  1912 ANSVMERIIEHRNREGFPGKAIQWGAIGEVGLVADMAEDKIDMEIGGTLQQRISSCIQELDHLLC 1976
            |||.||||.|.|.:|..||.|:||||||:||:|.:..... |..|||||.||:|||::.||..||
Zfish  2043 ANSTMERICEQRRQENLPGLAVQWGAIGDVGVVLETMGGN-DAVIGGTLPQRMSSCLEVLDRFLC 2106

  Fly  1977 ADASIVSSMVVAEKRTMRSGQG----NVIDAVMNIMGIRDLKSVSLSTTLSEMGMDSLMAVEIKQ 2037
            ....::||.|:|||..:..|:|    ::::||.:|:|:||:.|::...:|:::|:||||.||::|
Zfish  2107 QQRPVMSSFVLAEKVVVTKGEGSGQKDLVEAVAHILGVRDVNSLNADASLADLGLDSLMGVEVRQ 2171

  Fly  2038 TLERDFELILTPQDLRHLTFQKLQEFIDAKE---KENT----DGIQIIFASDNKLLGMELLIRNL 2095
            |||||:::::..:::|.||..||:|.  :|:   ||.:    .|.|.:..||        |.|.|
Zfish  2172 TLERDYDIVMAMREIRQLTINKLREL--SKQSGGKEESPVKRSGAQALLESD--------LSRML 2226

  Fly  2096 GDEANCD-QIIIPLQTSAAPSKQNLQPNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLE 2159
               .|.| ..:.||....:..:    |..::..:||:.. |:..|.:||..|...||..:.|.|:
Zfish  2227 ---VNPDGPTMAPLNEVQSAER----PLFLVHPIEGSIA-AFRTLTAKLSVPCYGLQCTKAAPLD 2283

  Fly  2160 NLKDVAQQSFDQIKLILKQTE-PFYIIAYSYGTFVALLLAEMLENSGFR-GHLMLLDGAPHFLKR 2222
            :::.:|....:.::.:  |.| |:.|..||:|..||..:...|:.:... .:|.|.||:..::..
Zfish  2284 SIQSLAAYYVECVRQV--QLEGPYRIAGYSFGACVAFEMCSQLQLAKCPVEYLFLFDGSHSYVAA 2346

  Fly  2223 LTNLHLG-------------------EQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQVDCL 2268
            .|..:..                   :||:     .:.::.::..:.|.:..|:      :||..
Zfish  2347 YTQSYRAKLTPGKESEAETEALCAFIQQFT-----GIEYNKLLETLLPLSDLEA------RVDKA 2400

  Fly  2269 SDKMSLFMNYVEKQNMYSKKYSSTMVKAMFNRVKMAASFDLDGII---KIKSPITLVRPAEASLQ 2330
            .|.::.....|.:..::..  :||    .::::|.|     |..:   |....:||:| |:||.:
Zfish  2401 VDLITSSHKNVSRDMLHFA--AST----FYHKLKAA-----DRYVPTSKYHGNVTLLR-AKASSE 2453

  Fly  2331 ---DIDEDYCISLLTSGVVTLKVIEGNHTTMLDN---PSLSQII 2368
               .:..||.:..:..|.|::.||||:|.|.|:.   .|:|.||
Zfish  2454 YGDGLGSDYKLHEVCDGKVSVHVIEGDHRTFLEGEGVESISSII 2497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	372/820 (45%)
		hot_dog	877..1125	CDD:469797	92/262 (35%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	38/114 (33%)
		PKS_ER	1443..1734	CDD:214840	135/290 (47%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	121/226 (54%)
		PKS_PP	2000..2067	CDD:214834	27/66 (41%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	32/165 (19%)
fasn	XP_009305081.1	PksD	1..>829	CDD:442550	378/833 (45%)
		hot_dog	873..1112	CDD:469797	89/243 (37%)
		UbiG	<1276..1354	CDD:441829	18/90 (20%)
		Rossmann-fold NAD(P)(+)-binding proteins	1331..>1530	CDD:473865	55/220 (25%)
		PKS_ER	1570..1860	CDD:214840	136/292 (47%)
		KR_1_FAS_SDR_x	<1863..2118	CDD:187657	124/255 (49%)
		PKS_PP	2134..>2186	CDD:214834	21/51 (41%)
		alpha/beta hydrolases	2245..2487	CDD:473884	59/271 (22%)