Protein Alignment FASN3 and Fasn

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: NP_059028.2
• Gene: Fasn / 50671
• RGDID: 620665
• Length: 2505
• Species: Rattus norvegicus
• Alignment Length: 2563
• Identity: 937/2563 - (36%)
• Similarity: 1429/2563 - (55%)
• Gaps: 267/2563 - (10%)

  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKICDLEKFDATFFG 83
            :::||:||:||.|...|:.|:...|...:|||.||:|||:.....:||||||:.||.||||:|||
  Rat     2 EEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLKDLSKFDASFFG 66

  Fly    84 VHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGGFG 148
            ||.|||||||||.|:|:|.:|||::|.|:||.||||:.|||::|...||:.:....:..:..|:.
  Rat    67 VHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLGYS 131

  Fly   149 ITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHPFV 213
            :.||.|||||||:|:....:|||..||||||||:.||.||:.|||:||..|||:||.||||.|..
  Rat   132 MVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAAIVGGINLLLKPNT 196

  Fly   214 TLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPEGI 278
            ::||.:||:|:|||.||.||.:.:||.|:|.:..:.|.||..|:||||:|:.:.||.||.|.:|:
  Rat   197 SVQFMKLGMLSPDGTCRSFDDSGNGYCRAEAVVAVLLTKKSLARRVYATILNAGTNTDGCKEQGV 261

  Fly   279 TYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGSVK 343
            |:|||..||:|:...|:.....|..|.|:|||.|||.||||:|...|...||:.|:.|||:||.|
  Rat   262 TFPSGEAQEQLIRSLYQPGGVAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQSPLLIGSTK 326

  Fly   344 SNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIGIN 408
            ||:||.|.|||:.:|.|...:.|.|:.|||::|......|..|.:|||.||...:|:....:|||
  Rat   327 SNMGHPEPASGLAALTKVLLSLENGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGIVGIN 391

  Fly   409 SFGFGGANAHALLKGYPKSKNNFGIPAD----DVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFI 469
            ||||||||.|.:|:     .|....||.    .:|.||..:|||.|||:.:.....::..|..|:
  Rat   392 SFGFGGANVHVILQ-----PNTQQAPAPAPHAALPHLLHASGRTMEAVQGLLEQGRQHSQDLAFV 451

  Fly   470 GLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSL 534
            .:|.:|.....:.|.||||.:...:|.      .::||.....|||:.::.||||:||..||.||
  Rat   452 SMLNDIAATPTAAMPFRGYTVLGVEGH------VQEVQQVPASQRPLWFICSGMGTQWRGMGLSL 510

  Fly   535 MIIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPD 599
            |.:..||||:....:.|...|:.:..:|.|.|...:.:|::|||.:.|:||.|.|:|.|:.::||
  Rat   511 MRLDSFRESILRSDEALKPLGVKVSDLLLSTDEHTFDDIVHSFVSLTAIQIALIDLLTSMGLKPD 575

  Fly   600 YIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIET 664
            .|||||:||:.|.||||.|:.::.:||||:||:...|.....||||||||.::......|..:..
  Rat   576 GIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDANLPAGSMAAVGLSWEECKQRCPPGVVP 640

  Fly   665 ACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHP 729
            ||||..|:.|||||...|.:||..||.:|:|||||....:|:||.::..:.|.||..:.::|..|
  Rat   641 ACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREP 705

  Fly   730 KPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAI 794
            :||:.:|||||:|:..|....|:..||||:.|||::.|||.|....:|::::.:|:|||.||.|:
  Rat   706 RPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAV 770

  Fly   795 LKRSM-PSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIR 858
            |||.: ||...|||..|.:::|..|||:.|||::|.|:.:....|:..::|||.|.||.:|..|:
  Rat   771 LKRGVKPSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGIDINPNALFPPVEFPVPRGTPLISPHIK 835

  Fly   859 WDHSEDWFVTKYENMK--TKSSGERVFSVNLASD-NEEFLSGHIIDGKILVPATCYLQYVWETF- 919
            ||||:.|.:...|:..  :.||...|::::.:|: ::.:|..|.|||::|.|.|.||..||:|.
  Rat   836 WDHSQTWDIPVAEDFPNGSSSSSATVYNIDASSESSDHYLVDHCIDGRVLFPGTGYLYLVWKTLA 900

  Fly   920 -SLMYHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETE 983
             ||..   |..:.||.||::.|.:||.:|..|.|.|.|.:...:..||:::.|:|:|:|.:.:.|
  Rat   901 RSLSL---SLEETPVVFENVTFHQATILPRTGTVPLEVRLLEASHAFEVSDSGNLIVSGKVYQWE 962

  Fly   984 NPSI-----PEVYNFQSKSKFPMIAKKDFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNYNW 1043
            :|..     |||...........:.:.:.||||:||||.|...||.|..|..:|..|::.|..||
  Rat   963 DPDSKLFDHPEVPIPAESESVSRLTQGEVYKELRLRGYDYGPHFQGVYEATLEGEQGKLLWKDNW 1027

  Fly  1044 VTFMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRVFDVYVDPMYDRIIAGG 1108
            |||||.||||.|||...::|.|||::..:.|:...|...:..::.:.:|.||.........::||
  Rat  1028 VTFMDTMLQISILGFSKQSLQLPTRVTAIYIDPATHLQKVYMLEGDTQVADVTTSRCLGVTVSGG 1092

  Fly  1109 IEIFGLHASLVQRRRPPG-IPVLEEYVFLPFFSSSILS--------------------------- 1145
            :.|..|..:...||:... :|.||::||.|......||
  Rat  1093 VYISRLQTTATSRRQQEQLVPTLEKFVFTPHVEPECLSESAILQKELQLCKGLAKALQTKATQQG 1157

  Fly  1146 LK---------------------------------------------------------NAARVC 1153
            ||                                                         .|.:.|
  Rat  1158 LKMTVPGLEDLPQHGLPRLLAAACQLQLNGNLQLELGEVLARERLLLPEDPLISGLLNSQALKAC 1222

  Fly  1154 VQIAIENNPTLKLKLVEVGADGKNHMLTEFIEAIQDLPVITGDYILLT--SQNLEDL-------- 1208
            :..|:||..|||:|:|||.| |:.|:.:.....:...|::..:|....  .|.|:|:
  Rat  1223 IDTALENLSTLKMKVVEVLA-GEGHLYSHISALLNTQPMLQLEYTATDRHPQALKDVQTKLQQHD 1286

  Fly  1209 --PGVHIENGSLSTQ--------TNCHIIIIGGYEEDEVHEKITSAYNVLVDNGYIVFR-----Q 1258
              .|....:|...|.        .||.:..:|     :....:.:....|.|.|:::..     .
  Rat  1287 VAQGQWDPSGPAPTNLGALDLVVCNCALATLG-----DPALALDNMVAALKDGGFLLMHTVLKGH 1346

  Fly  1259 KCAKNVSCKIAEKFRTISKIPINNTEE-----------NLVLLQK--------ISKKLTV--PPV 1302
            ...:.::|..:|    :...|...::|           :||.|:|        :.::|:.  .|:
  Rat  1347 ALGETLACLPSE----VQPGPSFLSQEEWESLFSRKALHLVGLKKSFYGTALFLCRRLSPQDKPI 1407

  Fly  1303 LVKVSQHDKTFEWILELQSAIITKA--PVVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFIDDD 1365
            .:.|  .|.:|:|:..|:|.:.|.:  ||.:.:.|...:|.:||||||||||.|:.|||..:.:.
  Rat  1408 FLPV--EDTSFQWVDSLKSILATSSSQPVWLTAMNCPTSGVVGLVNCLRKEPGGHRIRCILLSNL 1470

  Fly  1366 SA----PDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQRGDL 1426
            |:    |..|.............|..|:||:|:||::||.| |:.|:|.::..|.:.||:.||||
  Rat  1471 SSTSHVPKLDPGSSELQKVLESDLVMNVYRDGAWGAFRHFQ-LEQDKPEEQTAHAFVNVLTRGDL 1534

  Fly  1427 SSLQWLKGPF---------NSQNCHIKIAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGFEY 1482
            :|::|:..|.         .:|.|  .:.::||||||:|||||:|:.:........::|:||.|:
  Rat  1535 ASIRWVSSPLKHMQPPSSSGAQLC--TVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEF 1597

  Fly  1483 SGINMLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDIRK 1547
            ||.:. .|||:|.:|...|:|:.|......:||:|..|:|||||:|||||.|.||:..:...|:.
  Rat  1598 SGRDK-CGRRVMGLVPAEGLATSVLLSPDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQH 1661

  Fly  1548 GKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFELMV 1612
            |:::|||:|:||:|.|||.:||:....||||..:|.|:.:|...||:|.::...|||:||||..|
  Rat  1662 GETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHV 1726

  Fly  1613 HRETNGKGVDFVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVLAD 1677
            ...|.|||||.|||||:||||.||:|||.:.|.||||||:|::|::.:|:..|||.:|||.:|.|
  Rat  1727 LLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGILLD 1791

  Fly  1678 SLLVAPDEDIWHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQPHD 1742
            :|....::....:..|:...|.:|:::||...||...::|.|||::..|||||||::||||:..:
  Rat  1792 ALFEGANDSWREVAELLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVREEEPE 1856

  Fly  1743 ---PSTLP--VRVLNQVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQLY 1802
               |...|  :..:::.:...:.:|:|.|||||||:|||.|:.:|||::|:|:|..||...||..
  Rat  1857 AMLPGAQPTLISAISKTFCPEHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGYQAK 1921

  Fly  1803 RIALWKTYGCEVAISTADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECF 1867
            .:..|:..|..|.:||::::|.:|...|::||..:|||||:||||:||:|.:..||....|.:..
  Rat  1922 HVREWRRQGIHVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQDVN 1986

  Fly  1868 APKAIATTYLDDLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPGKA 1932
            .||...|..||..:|..||||::||.|||||||||||||||||.|||.||||.|.|..:|.||.|
  Rat  1987 KPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQSNYGFANSTMERICEQRRHDGLPGLA 2051

  Fly  1933 IQWGAIGEVGLVADMAEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSSMVVAEKRTMRSGQ 1997
            :||||||:||::.: |....|..:||||.||||||::.||..|....:::||.|:|||:.:..|.
  Rat  2052 VQWGAIGDVGIILE-AMGTNDTVVGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAHGD 2115

  Fly  1998 G----NVIDAVMNIMGIRDLKSVSLSTTLSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLTFQ 2058
            |    :::.||.:|:|||||..::|.::|:::|:||||.||::|.|||:.:|:|..:::|.||.:
  Rat  2116 GEAQRDLVKAVAHILGIRDLAGINLDSSLADLGLDSLMGVEVRQILEREHDLVLPIREVRQLTLR 2180

  Fly  2059 KLQEFIDAKEKENTDGIQIIFASDNKL----LGMELLIRNLGDEANCDQIIIPLQTSAAPSKQNL 2119
            |||| :.:|...:|:.......:|..|    |.:.:|:.|  .|.       |..|.....:.:.
  Rat  2181 KLQE-MSSKAGSDTELAAPKSKNDTSLKQAQLNLSILLVN--PEG-------PTLTRLNSVQSSE 2235

  Fly  2120 QPNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFDQIKLILKQTE-PFY 2183
            :|..::..:||:. ..::.|.:||..|...||..|.|.|:::.::|....|.||.:  |.| |:.
  Rat  2236 RPLFLVHPIEGSI-TVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQV--QPEGPYR 2297

  Fly  2184 IIAYSYGTFVALLLAEMLE----NSGFRGHLMLLDGAPHFLKRLTNLHLG--------------- 2229
            :..||:|..||..:...|:    .:....:|.|.||:..::...|..:..
  Rat  2298 VAGYSFGACVAFEMCSQLQAQQGPAPAHNNLFLFDGSHTYVLAYTQSYRAKLTPGCEAEAEAEAI 2362

  Fly  2230 ----EQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQVDCLSDKMSLFMNYVEK--QNMYSKK 2288
                :||.|.:     .|.::..:.|..|             |.|:::..::.:.:  |::..:.
  Rat  2363 CFFIKQFVDAE-----HSKVLEALLPLKS-------------LEDRVAAAVDLITRSHQSLDRRD 2409

  Fly  2289 YSSTMVKAMFNRVKMAASFDLDGIIKIKSPITLVRPAEASL--QDIDEDYCISLLTSGVVTLKVI 2351
            .|...|...:   |:.|:.......|....:.|:|......  :|:..||.:|.:..|.|::.:|
  Rat  2410 LSFAAVSFYY---KLRAADQYKPKAKYHGNVILLRAKTGGTYGEDLGADYNLSQVCDGKVSVHII 2471

  Fly  2352 EGNHTTMLDNPSLSQIIDDFDPVLLEDK 2379
            ||:|.|:|:...|..||:.....|.|.:
  Rat  2472 EGDHRTLLEGRGLESIINIIHSSLAEPR 2499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	370/824 (45%)
		hot_dog	877..1125	CDD:469797	88/255 (35%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	42/115 (37%)
		PKS_ER	1443..1734	CDD:214840	132/290 (46%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	116/226 (51%)
		PKS_PP	2000..2067	CDD:214834	30/66 (45%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	36/168 (21%)
Fasn	NP_059028.2	PksD	1..>818	CDD:442550	371/826 (45%)
		Acyl and malonyl transferases	429..817		159/393 (40%)
		N-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363	844..966		41/124 (33%)
		hot_dog	874..1009	CDD:469797	50/137 (36%)
		C-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363	983..1112		45/128 (35%)
		Methyltransf_12	1238..1337	CDD:400515	20/104 (19%)
		KR_1_FAS_SDR_x	1311..>1515	CDD:187657	55/215 (26%)
		PKS_ER	1558..1848	CDD:214840	133/292 (46%)
		Enoyl reductase	1629..1857		109/227 (48%)
		Beta-ketoacyl reductase	1858..2113		121/255 (47%)
		KR_1_FAS_SDR_x	<1870..2106	CDD:187657	116/236 (49%)
		entF	<2121..2318	CDD:236668	65/209 (31%)
		Thioesterase	2202..2505		71/331 (21%)
		Thioesterase	2236..2495	CDD:395776	61/282 (22%)