Protein Alignment FASN3 and FASN1

DIOPT Version :10

• Sequence 1: NP_001015405.3
• Gene: FASN3 / 3355111
• FlyBaseID: FBgn0287184
• Length: 2394
• Species: Drosophila melanogaster
• Sequence 2: NP_001137778.2
• Gene: FASN1 / 33524
• FlyBaseID: FBgn0283427
• Length: 2540
• Species: Drosophila melanogaster
• Alignment Length: 2469
• Identity: 989/2469 - (40%)
• Similarity: 1462/2469 - (59%)
• Gaps: 197/2469 - (7%)

  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKI--CDLEKFDATF 81
            |:|.|:|.:|:.|....|.|::..|::.:|||:||.|||......:|.|.||:  .|||.||..|
  Fly   140 DEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQF 204

  Fly    82 FGVHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGG 146
            ||||.|||..|||..|:|:|..:||:||:|:||..||||:||||||...||:|:.|..:.....|
  Fly   205 FGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNG 269

  Fly   147 FGITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHP 211
            :|:|||:|||.|||||:....:|||:.:|||||||:|||:.|||.:|.|::|.|::.|:.|:|.|
  Fly   270 YGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKP 334

  Fly   212 FVTLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPE 276
            .::|||.||.:|:|||.|:.||::.:||.||:....|.||:...|:||||||:..:||.||:|.:
  Fly   335 TMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQ 399

  Fly   277 GITYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGS 341
            |||||.|.:|.:|:.:.|::|...|:|:.|:|||.|||.||||:|..:|.:..|..|..|||:||
  Fly   400 GITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGS 464

  Fly   342 VKSNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIG 406
            ||||:||||.|||:||:.|...|.|.|:|..|:::.:....:..|.:|||.||...:|.....||
  Fly   465 VKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIG 529

  Fly   407 INSFGFGGANAHALLKGYPKSKNNFGIPADDVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFIGL 471
            :|||||||||||.:||..||.|..  .|.|...:::..:|||.||||::..:...|..|.|::.|
  Fly   530 LNSFGFGGANAHVILKSNPKPKAL--TPKDGALKVVLASGRTFEAVEQLLESASTNADDDEYLQL 592

  Fly   472 LQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSLMI 536
            :..|..:.:....||||.:.:.:||.     .::|......:|||.::||||||||..|...||.
  Fly   593 INEIHSKAIPNHFFRGYGVVSSKGTH-----QREVIESNDDKRPIWYIYSGMGSQWASMAKDLMK 652

  Fly   537 IPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPDYI 601
            |..|.::::.|..:|..:|::||.:||.:..:.::||||||:.|||:|:.|||:|.||.|.||.|
  Fly   653 IEAFAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGI 717

  Fly   602 IGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIETAC 666
            :||||||||||||||..|.:|.:||||:||:..:|.:..:|.||||||.::.....:|......|
  Fly   718 VGHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCFPVC 782

  Fly   667 HNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHPKP 731
            ||..|:||||||...:...||.|..:|:|||.|..|..|:|||||:..||.|...:.:|||:.|.
  Fly   783 HNSEDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAKN 847

  Fly   732 RTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAILK 796
            ||.:|:|||:|:..||...||..||.||.||||:.|||.|....:|||::::|:||||||.||||
  Fly   848 RTARWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQAILK 912

  Fly   797 RSM-PSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIRWD 860
            |:: |...::.|..||::||..|||:.:||::..|.......|...|.:||.|.||.::|.:.||
  Fly   913 RALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWD 977

  Fly   861 HSEDWFVTKYENMKTKSSGERVFSVNLASDNEEFLSGHIIDGKILVPATCYLQYVWETFSLMYHG 925
            |::.|.|.|:.  |..||||.:..|:|:.:::.||:||.|||:||.|||.|:...|:||:.| .|
  Fly   978 HTQKWLVAKFG--KETSSGETIVEVDLSKEDDAFLAGHTIDGRILFPATGYMTLAWQTFAKM-QG 1039

  Fly   926 PSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETENPSIPEV 990
            ..:...||..|::.|.|||.:..:..|...:....|||.|||.|.|||.|:|.|      :|||.
  Fly  1040 SEFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKI------TIPES 1098

  Fly   991 YNFQSKSKFPM-------IAKK----DFYKELKLRGYHYNGAFQAVNLARSDGL--FGRVQWNYN 1042
            .:   ..:.|:       :||:    |.||||:||||.|.|.|:.:  .|||.:  .|::||..|
  Fly  1099 ID---NEELPLEEQTPSAVAKELGTNDVYKELRLRGYDYGGIFRGI--VRSDTVASTGKLQWVDN 1158

  Fly  1043 WVTFMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRV---------FDVYVD 1098
            |::|||.|||..||..:.|.|.|||:|.:..||...||:|::.:..|.:|         .|:.|
  Fly  1159 WISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDINV- 1222

  Fly  1099 PMYDRIIAGGIEIFGLHASLVQRRRPPGI---PVLEEYVFLPFFSSSILSLK------NAARVCV 1154
                 |.:.|:|:.||.|:|.|||  ||.   |.||.|.|:|..:::.|:..      :|..|.:
  Fly  1223 -----IKSAGVELRGLKANLAQRR--PGTQAPPTLERYQFVPNINTTDLNENSEKARLHALDVAI 1280

  Fly  1155 QIAIENNP-TLKLKLVEVGADGKNH---MLTEFIEAIQDLPVITGDYILLTSQNLEDL------- 1208
            |:.|||:. .:|||.||: |:|:|.   :....::.|:..||:|||..::||.|.|:.
  Fly  1281 QVIIENSSGAVKLKGVEL-ANGRNPDVLVANRLLQIIEGEPVLTGDVAVVTSNNNEETITAALGD 1344

  Fly  1209 PGVHIENGSL---STQTNCHII----IIGGYEEDEVHEKITSAYNVLVDNGYIVFRQ------KC 1260
            .||.:.:..:   ..:.|||.:    ::...:...:...|.|    :.:||:::..:      |.
  Fly  1345 SGVRVVSKDVLKEPVEQNCHFVFGIDVLSRPDTKTLENSIAS----IRENGFLILEETLPTYTKT 1405

  Fly  1261 AKNVSCKIAEKFRTISKIPINNTEENLVLLQKISKKLTVPPVLVKVSQHDKTFEWILELQSAIIT 1325
            .:.:..|..  |..:.:..:..|.. |||.:|.....|...|:|..:  ::.|.|:.:|::|:.|
  Fly  1406 GRALLTKFG--FVAVQEQSLGATRV-LVLARKAVDLKTRKSVVVVAT--EQNFNWVDDLKAALAT 1465

  Fly  1326 KAP----VVVYSFNEKLNGQIGLVNCLRKEPDGNLIRCFFIDDDSAPDFDLSHPFYSTQYSLGLA 1386
            .|.    |.|....|:|.|.:||:.|::.|..|.|.|..|:.|..|..|.|:...|..|....|.
  Fly  1466 AATEEQYVYVVCQGEELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLYRQQLEKDLI 1530

  Fly  1387 FNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYGNVIQRGDLSSLQWLKG---------PFNSQNCH 1442
            .|:.:||:||::|||: |:..|.:.:::|.|.|.:.:|||:||:|::.         ..|.:.|
  Fly  1531 SNVLKNGAWGTFRHLK-LETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETC- 1593

  Fly  1443 IKIAFSSLNFRDVMLATGRLAVELYGSSRIDQNCVLGFEYSGINMLTGRRIMSMVVKGGVASYVE 1507
             .:.::.:|||||||.:|:||.:.......:|:||||.|::|.: ..|||:|:||....:|:...
  Fly  1594 -TVYYAPINFRDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRD-TQGRRVMAMVPAKSLATTCV 1656

  Fly  1508 KPSKLIWDIPDDWSLEEAATVPVVYITVYYAFFMATDIRKGKSILIHAGTGGIGLAAIRVALAYN 1572
            ...:::|.||:.|::|||:|||.||.|||||..:...::||:.||||||:||:|.|||.||||:.
  Fly  1657 ASKRMMWQIPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHG 1721

  Fly  1573 LEVFTTCSTANKKEFLLKTFPKLKESHIGNSRNTSFELMVHRETNGKGVDFVLNSLSEEKLLASL 1637
            |.||||..:..|:|||||.||||:|.:|||||:||||.:|.|||.|:|||.||||||||||.||:
  Fly  1722 LTVFTTVGSKEKREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASI 1786

  Fly  1638 RCLGKSGHFLEIGKYDMANDNKIGLGCFLKEITFHAVLADSLLVAPDEDIWHLKSLIDMDISNGI 1702
            ||||.:|.||||||:|::|::.:|:..|||..:||.:|.||::...:|....:.||:...|..|.
  Fly  1787 RCLGLNGRFLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGA 1851

  Fly  1703 IQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQVREQPHDPSTL--PVRVLNQV---YFKHNHTY 1762
            :.|||..||...::|||||.:..|||||||||:||::......|  ..|::|.:   |.....:|
  Fly  1852 VVPLPTSVFNDQQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIPRTYMHPEKSY 1916

  Fly  1763 VIPGGLGGFGMELADWMAIRGARKLLLSSSRGITKDYQLYRIALWKTYGCEVAISTADITSKKGC 1827
            ::.|||||||:||.:|:..||||.::|:|..|:...||...|..|:..|.:|.|.|:|:|:..|.
  Fly  1917 ILVGGLGGFGLELTNWLVTRGARYIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGA 1981

  Fly  1828 AQLLSEANGMGPVGGIFNLAVVLKDCIFSNQNVNQFLECFAPKAIATTYLDDLSRIYCPELEHFV 1892
            .:||..:|.:..||||||||.||:|.:..:|....|.....||..||.|||..||..|.||::|:
  Fly  1982 KKLLENSNKLALVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFI 2046

  Fly  1893 VFSSVSCGRGNAGQSNYGMANSVMERIIEHRNREGFPGKAIQWGAIGEVGLVADMAEDKIDMEIG 1957
            .||||||||||.||:|||:|||.||||.|.|...||||.||||||||:.|||.:...|. |..||
  Fly  2047 CFSSVSCGRGNIGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLGDN-DTVIG 2110

  Fly  1958 GTLQQRISSCIQELDHLLCADASIVSSMVVAEKRTMRSGQG-NVIDAVMNIMGIRDLKSVSLSTT 2021
            |||.||:.||:|.:|..|.....:|:||||||||......| ::|..:.||:|:||.|::....:
  Fly  2111 GTLPQRMPSCLQTIDLFLQQPHPVVASMVVAEKRKSDQSAGVSLIATIANILGLRDTKNIQDGAS 2175

  Fly  2022 LSEMGMDSLMAVEIKQTLERDFELILTPQDLRHLTFQKLQEF---IDAK-------------EKE 2070
            |:::||||||:.||||||||:|:::|:.|::|.|||..|:..   .|.|             |..
  Fly  2176 LADLGMDSLMSAEIKQTLERNFDIVLSAQEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEAN 2240

  Fly  2071 NT------------DGIQIIFASDNKLLGMELLIRNLGDEANCDQIIIPLQTSA-APSKQNLQPN 2122
            .|            ||.|::|.:.        ||..        :.|:.|.|.| |.|||:  |.
  Fly  2241 ITSGGSSRTASPMGDGTQVVFTTS--------LIPT--------EAIVQLDTKAPANSKQS--PI 2287

  Fly  2123 IIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFDQIKLILKQTEPFYIIAY 2187
            ..|..:||.|. |...|..:|:.||..||..:....::|:..|:....|::.: :...|:.:..|
  Fly  2288 FFISPIEGFAS-ALEPLAKRLEVPAYGLQYTEAVPSDSLESAAKFFIKQLRTV-QPKGPYKLAGY 2350

  Fly  2188 SYGTFVALLLAEMLENSGFRGHLMLLDGAPHFLKRLTNLHLGEQF-------SDNDLYDLLFSSI 2245
            |:|..:..::|.:||.:....::::|||||.::...|: ...:::       :||..|.|.:..|
  Fly  2351 SFGCLLTYVMAGILEETNEVANVIMLDGAPSYVNWYTS-SFKQRYTDGTNADNDNQSYGLAYFGI 2414

  Fly  2246 VNHIFPEASKESMSTVFHQVDCLSDKMSLFMNYVEK---QNMYSKKYSSTMVKAMFNRVKMAASF 2307
            |   ......:::..:...:....:|:..|...:..   |.:.:.|.|:|:   .:.::::|
  Fly  2415 V---LANIDYKALVRLLIVIPTWEEKLERFAELMSNEITQPVETIKKSATL---FYKKLELA--- 2470

  Fly  2308 DLDG---IIKIKSPITLVRPAEASLQDIDEDYCISLLTSGVVTLKVIEGNHTT-MLDNPSLSQI 2367
              ||   .:|:|:.:|||:|.:.|.: :||||.:..:.:..|.:..:||||.| ::::.||..|
  Fly  2471 --DGYQPTLKLKTNVTLVKPTDNSAK-LDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTI 2531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASN3	NP_001015405.3	PksD	16..>839	CDD:442550	382/822 (46%)
		hot_dog	877..1125	CDD:469797	104/269 (39%)
		Rossmann-fold NAD(P)(+)-binding proteins	<1301..>1411	CDD:473865	38/113 (34%)
		PKS_ER	1443..1734	CDD:214840	148/290 (51%)
		KR_1_FAS_SDR_x	<1761..1988	CDD:187657	115/226 (51%)
		PKS_PP	2000..2067	CDD:214834	31/69 (45%)
		alpha/beta hydrolases	2120..>2265	CDD:473884	34/151 (23%)
FASN1	NP_001137778.2	PksD	139..>950	CDD:442550	382/816 (47%)
		hot_dog	990..1193	CDD:469797	87/214 (41%)
		Rossmann-fold NAD(P)(+)-binding proteins	1358..>1550	CDD:473865	53/201 (26%)
		PKS_ER	1593..1883	CDD:214840	149/292 (51%)
		KR_1_FAS_SDR_x	<1901..2141	CDD:187657	117/240 (49%)
		PKS_PP	2154..>2206	CDD:214834	25/51 (49%)
		EntF2	<2284..2540	CDD:442548	64/265 (24%)