DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN3 and FASN

DIOPT Version :10

Sequence 1:NP_001015405.3 Gene:FASN3 / 3355111 FlyBaseID:FBgn0287184 Length:2394 Species:Drosophila melanogaster
Sequence 2:NP_004095.4 Gene:FASN / 2194 HGNCID:3594 Length:2511 Species:Homo sapiens


Alignment Length:2580 Identity:919/2580 - (35%)
Similarity:1426/2580 - (55%) Gaps:295/2580 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DDIVISGMAGKFPNCRNITEYQYKLYNKIDMVDDDERRWRHFNPEIPKRSGKICDLEKFDATFFG 83
            :::||:||:||.|...|:.|:...|...:|||.||:|||:.....:|:||||:.||.:|||:|||
Human     2 EEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFG 66

  Fly    84 VHFKQAHTMDPQTRILIETAYEAVIDSGVNPKSLRGSKTGVYIGSCISESEKTWFYEKVSSGGFG 148
            ||.|||||||||.|:|:|..|||::|.|:||.||||:.|||::|...||:.:....:..:..|:.
Human    67 VHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYS 131

  Fly   149 ITGCSRAMMANRISYCLGLEGPSFLLDTACSSSMYALDNAFSAIRNGEIDAAIIGGSNLLLHPFV 213
            :.||.|||||||:|:.....|||..||||||||:.||.||:.||.:|:..|||:||.|:||.|..
Human   132 MVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNT 196

  Fly   214 TLQFARLGVLAPDGFCRPFDKNASGYTRSETINCLFLQKKKHAKRVYASIVYSKTNCDGYKPEGI 278
            ::||.|||:|:|:|.|:.||...:||.|||.:..:.|.||..|:||||:|:.:.||.||:|.:|:
Human   197 SVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGV 261

  Fly   279 TYPSGIVQEKLLDQFYKDIDHKPSDLGYLEAHSTGTVVGDPEECKAIDNVLCSQREEPLLVGSVK 343
            |:|||.:||:|:...|:.....|....|:|||.|||.||||:|...|...||:.|:||||:||.|
Human   262 TFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTK 326

  Fly   344 SNVGHSEAASGICSLVKACFAFETGLIAPNINFTEVKQIIAPLAEGRLIVVKDVVPLPKPYIGIN 408
            ||:||.|.|||:.:|.|...:.|.||.|||::|......|..|.:|||.||...:|:....:|||
Human   327 SNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGIN 391

  Fly   409 SFGFGGANAHALLKGYPKSKNNFGIPAD----DVPRLLTWAGRTEEAVEEIFNAVEKNPLDAEFI 469
            ||||||:|.|.:|:     .|....||.    .:||||..:|||.|||:::.....::..|..|:
Human   392 SFGFGGSNVHIILR-----PNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFL 451

  Fly   470 GLLQNIQEEDVSGMVFRGYAIFAKQGTGPCKLLAKDVQHYTGLQRPIVWVYSGMGSQWNQMGNSL 534
            .:|.:|.....:.|.|||||:...:..||      :||.....:||:.::.||||:||..||.||
Human   452 SMLNDIAAVPATAMPFRGYAVLGGERGGP------EVQQVPAGERPLWFICSGMGTQWRGMGLSL 510

  Fly   535 MIIPRFRESVEICHQILLAKGLNLIHILTSNDPEVYQNILNSFVGIAAVQIGLTDVLRSLNIQPD 599
            |.:.|||:|:....:.:...||.:..:|.|.|...:.:|::|||.:.|:||||.|:|..:.::||
Human   511 MRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPD 575

  Fly   600 YIIGHSVGELGCAYADGGLTAQQMILAAYYRGRVSVDLEKIRGSMAAVGLGYKTVLHMLPKSIET 664
            .|:|||:||:.|.||||.|:.::.:||||:||:...:.....|:||||||.::......|..:..
Human   576 GIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVP 640

  Fly   665 ACHNGPDSCTISGPVDDVAQFVADLKTKGIFAKEVPCSNIAYHSKYISHMGPPLLNYMNEIIPHP 729
            ||||..|:.|||||...|.:||..|:.:|:|||||....:|:||.::..:.||||..:.::|..|
Human   641 ACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREP 705

  Fly   730 KPRTKKWLSTSVPKIDWNKDKAKFCSAEYHTNNLLNSVLFDETFSLIPKNSLTIEVAPHGLLGAI 794
            |||:.:|||||:|:..|:...|:..||||:.|||::.|||.|....:|::::.:|:|||.||.|:
Human   706 KPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAV 770

  Fly   795 LKRSM-PSGVHIPLTNRGNQNNASFFLSALGKIYLNGVLLPAANLYERIQFPVSRTTPSVSSLIR 858
            |||.: ||...|||..:.:::|..|||:.:|:::|:|:......|:..::||..|.||.:|.||:
Human   771 LKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIK 835

  Fly   859 WDHSEDWFVTKYENMK--TKSSGERVFSVNLASDN-EEFLSGHIIDGKILVPATCYLQYVWETFS 920
            ||||..|.|...|:..  :.|....:::::.:|:: :.:|..|.:||::|.|||.||..||:|.:
Human   836 WDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLA 900

  Fly   921 LMYHGPSYMDVPVEFEDIRFIRATSMPVDGKVDLTVMIHYGTGHFEITEMGSLVVTGIIRETENP 985
            ... |.....:||.|||:...:||.:|..|.|.|.|.:...:..||::|.|:|||:|.:.:.::|
Human   901 RAL-GLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDP 964

  Fly   986 SIPEVYNF-QSKSKFP----MIAKKDFYKELKLRGYHYNGAFQAVNLARSDGLFGRVQWNYNWVT 1045
            . |.:::. :|.:..|    .:|:.:.||||:||||.|...||.:..|..:|..||:.|..|||:
Human   965 D-PRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVS 1028

  Fly  1046 FMDAMLQIQILGTDSRNLLLPTKIRKLKINGVHHFDLMTKMDPENRVFDVYVDPMYDRIIAGGIE 1110
            |||.|||:.|||:....|.|||::..:.|:...|...:..:..:.:|.||.|.......:|||:.
Human  1029 FMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVH 1093

  Fly  1111 IFGLHA-SLVQRRRPPGIPVLEEYVFLPFFSSSILS----------------------------- 1145
            |.|||. |..:|::...:|:||::.|.|......||                             
Human  1094 ISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLK 1158

  Fly  1146 ----------------------LKNAA-------------------------------------- 1150
                                  |.:||                                      
Human  1159 MVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPA 1223

  Fly  1151 -RVCVQIAIENNPTLKLKLVEVGADGKNHMLTEFIEAIQDLPVITGDYILLTSQNLEDLPGVHIE 1214
             :.|:..|:||.|:||:|:|||.| |..|:.:.....:...|::...| ..|.::.:.|.....|
Human  1224 LKACLDTAVENMPSLKMKVVEVLA-GHGHLYSRIPGLLSPHPLLQLSY-TATDRHPQALEAAQAE 1286

  Fly  1215 --------------------NGSLSTQT-NCHIIIIGGYEEDEVHEKITSAYNVLVDNGYI---- 1254
                                .||..... ||.:..:|     :....:::....|.:.|::    
Human  1287 LQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALG-----DPASALSNMVAALREGGFLLLHT 1346

  Fly  1255 ------------------------VFRQKCAKNVSCKIAEKFRTISKIPINNTEENLVLLQKISK 1295
                                    :..|...:::..:::.:...:.|....:|   |.|.::.:.
Human  1347 LLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGST---LFLCRRPTP 1408

  Fly  1296 KLTVPPVLVKVSQHDKTFEWILELQSAII---TKAPVVVYSFNEKLNGQIGLVNCLRKEPDGNLI 1357
            :.:  |:.:.|.  |.:|.|:..|:..:.   :..||.:.:.|...:|.:|||||||:||.||.:
Human  1409 QDS--PIFLPVD--DTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRL 1469

  Fly  1358 RCFFIDDDSA----PDFDLSHPFYSTQYSLGLAFNIYRNGSWGSYRHLQLLKNDQPSKRLDHIYG 1418
            ||..:.:.|:    |:.|.............|..|:||:|:||::||. ||:.|:|.:...|.:.
Human  1470 RCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHF-LLEEDKPEEPTAHAFV 1533

  Fly  1419 NVIQRGDLSSLQWLKGPF--------NSQNCHIKIAFSSLNFRDVMLATGRLAVELYGSSRIDQN 1475
            :.:.||||||::|:....        .:|.|  .:.::||||||:|||||:|:.:........|:
Human  1534 STLTRGDLSSIRWVCSSLRHAQPTCPGAQLC--TVYYASLNFRDIMLATGKLSPDAIPGKWTSQD 1596

  Fly  1476 CVLGFEYSGINMLTGRRIMSMVVKGGVASYVEKPSKLIWDIPDDWSLEEAATVPVVYITVYYAFF 1540
            .:||.|:||.: .:|:|:|.:|...|:|:.|......:||:|.:|:|||||:|||||.|.|||..
Human  1597 SLLGMEFSGRD-ASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALV 1660

  Fly  1541 MATDIRKGKSILIHAGTGGIGLAAIRVALAYNLEVFTTCSTANKKEFLLKTFPKLKESHIGNSRN 1605
            :...:|.|:::|||:|:||:|.|||.:||:....||||..:|.|:.:|...||:|..:...|||:
Human  1661 VRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRD 1725

  Fly  1606 TSFELMVHRETNGKGVDFVLNSLSEEKLLASLRCLGKSGHFLEIGKYDMANDNKIGLGCFLKEIT 1670
            ||||..|...|.|||||.|||||:||||.||:|||...|.||||||:|::.::.:|:..|||.:|
Human  1726 TSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVT 1790

  Fly  1671 FHAVLADSLLVAPDEDIWHLKSLIDMDISNGIIQPLPVKVFLAHEIEQAFRHLIGGKHIGKVVIQ 1735
            ||.||.|:.......|...:.:|:...|.:|:::||...||...::|.|||::..||||||||:|
Human  1791 FHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQ 1855

  Fly  1736 V-REQPH------DPSTLPVRVLNQVYFKHNHTYVIPGGLGGFGMELADWMAIRGARKLLLSSSR 1793
            | .|:|.      .|..:  ..:::.:...:.:|:|.|||||||:|||.|:..||.:||:|:|..
Human  1856 VLAEEPEAVLKGAKPKLM--SAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRS 1918

  Fly  1794 GITKDYQLYRIALWKTYGCEVAISTADITSKKGCAQLLSEANGMGPVGGIFNLAVVLKDCIFSNQ 1858
            ||...||..::..|:..|.:|.:||::|:|.:|...|::||..:|||||:|||||||:|.:..||
Human  1919 GIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQ 1983

  Fly  1859 NVNQFLECFAPKAIATTYLDDLSRIYCPELEHFVVFSSVSCGRGNAGQSNYGMANSVMERIIEHR 1923
            ....|.:...||...|..||.::|..||||::||||||||||||||||||||.|||.||||.|.|
Human  1984 TPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKR 2048

  Fly  1924 NREGFPGKAIQWGAIGEVGLVADMAEDKIDMEIGGTLQQRISSCIQELDHLLCADASIVSSMVVA 1988
            ..||.||.|:||||||:||::.:..... |..:.|||.||::||::.||..|.....::||.|:|
Human  2049 RHEGLPGLAVQWGAIGDVGILVETMSTN-DTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLA 2112

  Fly  1989 EKRTM---RSGQGNVIDAVMNIMGIRDLKSVSLSTTLSEMGMDSLMAVEIKQTLERDFELILTPQ 2050
            ||...   |..|.::::||.:|:|||||.:|:|.::|:::|:||||:||::|||||:..|:|:.:
Human  2113 EKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVR 2177

  Fly  2051 DLRHLTFQKLQEFIDAKEKE---------NTDGIQIIFASDNKLLGMELLIRNLGDEANCDQIII 2106
            ::|.||.:|||| :.:|..|         ..||:    |.....|.:..|:.|  .|......:.
Human  2178 EVRQLTLRKLQE-LSSKADEASELACPTPKEDGL----AQQQTQLNLRSLLVN--PEGPTLMRLN 2235

  Fly  2107 PLQTSAAPSKQNLQPNIIIPGLEGTAGRAWYQLGSKLQSPAIVLQLHQFAHLENLKDVAQQSFDQ 2171
            .:|:|.       :|..::..:||:. ..::.|.|:|..|...||..:.|.|:::..:|....|.
Human  2236 SVQSSE-------RPLFLVHPIEGST-TVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDC 2292

  Fly  2172 IKLILKQTE-PFYIIAYSYGTFVALLLAEMLE---------NSGFRGHLMLLDGAPHFLKRLTNL 2226
            |:.:  |.| |:.:..||||..||..:...|:         ||     |.|.||:|.::...|..
Human  2293 IRQV--QPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNS-----LFLFDGSPTYVLAYTQS 2350

  Fly  2227 HLG-------------------EQFSDNDLYDLLFSSIVNHIFPEASKESMSTVFHQVDCLSDKM 2272
            :..                   :||:|.:     .:.::..:.|             :..|.:::
Human  2351 YRAKLTPGCEAEAETEAICFFVQQFTDME-----HNRVLEALLP-------------LKGLEERV 2397

  Fly  2273 SLFMNYVEKQNM-YSKKYSSTMVKAMFNRVKMAASFDLDGIIKIKSPITLVRPAEASL--QDIDE 2334
            :..::.:.|.:. ..::..|...::.:.:::.|..:....  |....:.|:|......  :|:..
Human  2398 AAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKA--KYHGNVMLLRAKTGGAYGEDLGA 2460

  Fly  2335 DYCISLLTSGVVTLKVIEGNHTTMLDNPSLSQIIDDFDPVLLEDK 2379
            ||.:|.:..|.|::.||||:|.|:|:...|..||......|.|.:
Human  2461 DYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPR 2505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN3NP_001015405.3 PksD 16..>839 CDD:442550 362/824 (44%)
hot_dog 877..1125 CDD:469797 88/254 (35%)
Rossmann-fold NAD(P)(+)-binding proteins <1301..>1411 CDD:473865 39/116 (34%)
PKS_ER 1443..1734 CDD:214840 132/290 (46%)
KR_1_FAS_SDR_x <1761..1988 CDD:187657 116/226 (51%)
PKS_PP 2000..2067 CDD:214834 32/66 (48%)
alpha/beta hydrolases 2120..>2265 CDD:473884 36/173 (21%)
FASNNP_004095.4 PksD 1..1358 CDD:442550 502/1375 (37%)
Acyl and malonyl transferases. /evidence=ECO:0000250 429..817 155/393 (39%)
N-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363 838..966 42/129 (33%)
C-terminal hotdog fold. /evidence=ECO:0000255|PROSITE-ProRule:PRU01363 981..1108 48/126 (38%)
KR_1_FAS_SDR_x 1316..>1522 CDD:187657 47/218 (22%)
PKS_ER 1564..1854 CDD:214840 133/292 (46%)
Enoyl reductase. /evidence=ECO:0000250 1635..1863 111/227 (49%)
Beta-ketoacyl reductase. /evidence=ECO:0000250 1864..2118 120/256 (47%)
KR_1_FAS_SDR_x <1876..2112 CDD:187657 116/236 (49%)
PKS_PP 2111..>2179 CDD:214834 30/67 (45%)
Thioesterase. /evidence=ECO:0000250 2207..2511 70/340 (21%)
Thioesterase 2242..2488 CDD:395776 56/273 (21%)

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